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Excitation-Contraction Coupling in Canine Tracheal Smooth Muscle Cells

  • J.-P. Bourreau
  • C. Y. Kwan
  • E. E. Daniel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

In canine tracheal smooth muscle, the significance of depolarization induced by acetylcholine is puzzling because it has no role in contraction. We proposed earlier a model where refilling of ACh-sensitive intracellular Ca2+ stores was in part achieved by a mechanism involving a direct influx of extracellular Ca2+ into the ACh-sensitive Ca2+ store through a dihydropyridine-sensitive channel. Putney proposed that different phases of the calcium response in non excitable cells may be intimately linked with IP3 first stimulating release of calcium from intracellular stores and the empty stores themselves then providing the signal that stimulates calcium entry. We examined in tracheal smooth muscle the essential feature of Putney’s model, that the intracellular stores themselves exert a major control over calcium entry.

Keywords

Krebs Solution Tracheal Smooth Muscle Cyclopiazonic Acid Sarcoplasmic Reticulum Calcium Store Loading 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • J.-P. Bourreau
    • 1
  • C. Y. Kwan
    • 1
  • E. E. Daniel
    • 1
  1. 1.Department of Biomedical SciencesMcMaster UniversityCanada

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