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Calyculin a Modulates Voltage-Dependent Outward Current in Guinea-Pig Taenia Coli Smooth Muscle Cells

  • Kazuo Obara
  • Toshihiro Usuki
  • Hideyo Yabu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

Protein kinases modulate the electrical activity of various cells through their action on membrane ion channels. In cardiac and smooth muscle cells, enhancement of a number of K+ currents by β-adrenergic agonists, such as isoproterenol (ISP), may result from a direct phosphorylation of K+ channel protein by cAMP-dependent protein kinase (A kinase) (Kolb, 1990). On the other hand, calyculin A (CL-A) which is a toxin isolated from marine sponge (Discodermia calyx) has a potent inhibitory action on protein phosphatase activities (Ishihara et al., 1989).

Keywords

Okadaic Acid Outward Current Marine Sponge Potent Inhibitory Action Protein Phosphatase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ishihara, H., Martin, B.L., Brautigan, D.L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watanabe, S., Hashimoto, K., Uemura, D. and Hartshorne, D.J., 1989, Calyculin A and okadaic acid: Inhibition of protein phosphatase activity, Biochem. Biophys. Res. Commun., 159: 871–877.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Kazuo Obara
    • 1
  • Toshihiro Usuki
    • 1
  • Hideyo Yabu
    • 1
  1. 1.Department of PhysiologySapporo Medical CollegeJapan

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