Active and Passive Forces During Ischemia and Reperfusion of Rat Fast and Slow Twitch Skeletal Muscles

  • Andrew J. Carvalho
  • Nancy H. McKee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


The present study shows for the first time, the response in active and passive forces of skeletal muscles to tourniquet ischemia. These responses were shown for both fast and slow twitch muscle types in the same rat hindlimb. Our data agrees partially with metabolic studies on ischemic skeletal muscles. The differences may be due to inhibition of excitation of myofilaments.


Skeletal Muscle Acute Ischemia Muscle Type Passive Force Extracellular Potassium Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B. Soussi, J.P. Idstrom, A.C. Bylund-Fellenius, and T. Schersten. Dynamics of skeletal muscle energetics during ischemia and reperfusion assessed by in vivo 31PNMR. NMR in Biomedicine 3:71–77 (1990).Google Scholar
  2. 2.
    E. Jennische, H. Hagberg, and H. Haljamae. Extracellular potassium concentration and membrane potential in rabbit gastrocnemius muscle during tourniquet ischemia. European J. Physiol. 392: 335–339 (1982).CrossRefGoogle Scholar
  3. 3.
    W.J. Leijendekker, W.D. Gao, and H.E. DJ. ter Keurs. Unstimulated force during hypoxia of rat cardiac muscle: stiffness and calcium dependence. Am. J. Physiol. 258: H861–H869 (1990).PubMedGoogle Scholar
  4. 4.
    R.J. Hajjar and J.K. Gwathmey. Direct evidence of changes in myofilament responsiveness of Ca2+ during hypoxia and reoxygenation in myocardium. Am. J. Physiol. 259: H784–H795 (1990).PubMedGoogle Scholar
  5. 5.
    J.P. Idstrom, B. Soussi, A. Elander, and A. C. Bylund-Fellenius. Purine metabolism after in vivo ischemia and reperfusion in rat skeletal muscle. Am. J. Physiol. 258: H1668–H1673, 1990.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Andrew J. Carvalho
    • 1
  • Nancy H. McKee
    • 1
  1. 1.Departments of Surgery and Community HealthUniversity of TorontoTorontoCanada

Personalised recommendations