Calcium and Potassium Channel Regulation by Protein Phosphorylation in Smooth Muscle Cells of Guinea Pig Taenia Coli
Generally speaking, Ca2+ influx through membrane in smooth muscle cells may play a crucial role in Excitation-Contraction Coupling. Mammalian smooth muscle cells are universally endowed with a lot of L-type, dihydropyridine-sensitive voltage-dependent Ca2+ channels and various kinds of K+ channels. Actually, Ca2+ conductances are increased by membrane depolarization causing Ca2+ influx and subsequent contraction.
KeywordsSmooth Muscle Cell Phorbol Ester Okadaic Acid Outward Current Inositol Trisphosphate
Unable to display preview. Download preview PDF.
- Ishihara, H., Martin, B.L., Brautigan, D.L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K., Uemura, D. and Hartshorne, D.J., 1989, Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity, Biochem. Biophys. Res. Commun., 159: 871–877.PubMedCrossRefGoogle Scholar
- Yabu, H., Yoshino, M., Usuki, T., Someya, T., Obara, K., Ozaki, H. and Karaki, H., 1990, Modification by calyculin A of inward Ca currents in smooth muscle cells isolated from guinea pig taenia coli, in: “Frontiers in Smooth Muscle Research”, N. Sperelakis and J.D. Wood, eds., pp623–626, Wiley-Liss, New York.Google Scholar