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Interaction of ICa with INa/Ca2 [Ca++]i and Ca++ Binding Proteins in Frog Atrium: A Theoretical Study

  • R. L. Rasmusson
  • D. L. Campbell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

The sarcoplasmic reticulum (S-R) of cells from the atrium of the bullfrog (Rana catesbeiana) is not involved in the cyclic uptake and release of calcium under normal physiological conditions. Consequently, bullfrog atrial cells provide a system in which the interactions between the “L”-type calcium current (ICa), sodium-calcium exchange current (INa/Ca) and intracellular Ca++ binding proteins (calmodulin and two different classes of Ca++ binding sites on troponin: TCa, a calcium-specific binding site thought to be responsible for phasic tension generation, and TMg, a Ca++−Mg++ competitive binding site) may be examined in isolation from complications arising from S−R uptake and release. A Hodgkin and Huxley type model1 incorporating INa/Ca and intracellular Ca++ binding sites has been used to examine the potential interactions between these different mechanisms during the cardiac action potential.

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References

  1. 1.
    Rasmusson, R.L., Clark, J.W., Giles, W.R., Robinson, K., Clark, R.B., Shibata, E.F., and Campbell, D.L., Am. J. Physiol., 259:H370–H389, (1990).PubMedGoogle Scholar
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    Doerr, T., Denger, R. and Trautwein, W., Pfluegers Arch. 413:599–603, (1989).CrossRefGoogle Scholar
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    Mazzanti, M. and DeFelice, L.J., Biophvs. J. 58:1059–1065, (1990).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • R. L. Rasmusson
    • 1
  • D. L. Campbell
    • 2
  1. 1.Departments of Biomedical EngineeringDuke UniversityDurhamUK
  2. 2.Departments of PharmacologyDuke UniversityDurhamUK

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