Effects of Cyclopiazonic Acid, an Inhibitor of the Ca++ Atpase of Sarcoplasmic Reticulum, on Ca++ Transport, Contraction and Relaxation in Cardiac Muscle

  • Philippe Lahouratate
  • Marie Josée Quiniou
  • Claude Léoty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


Cyclopiazonic acid is a potent inhibitor of cardiac sarcoplasmic reticulum Ca++ ATPase. It scarcely affects inotropism but significantly impairs lusitropism suggesting a greater role for cardiac sarcoplasmic reticulum in the control of cardiac relaxation than in the control of cardiac contraction.


Sarcoplasmic Reticulum Negative Inotropic Effect Cardiac Contraction Cyclopiazonic Acid Cardiac Sarcoplasmic Reticulum 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Philippe Lahouratate
    • 1
  • Marie Josée Quiniou
    • 1
  • Claude Léoty
    • 2
  1. 1.SmithKline Beecham Laboratoires PharmaceutiquesSt. Gregoire CedexFrance
  2. 2.UA CNRS 1340, Laboratoire de Physiologie GénéraleENVNantes Cedex 03France

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