Effects of Cyclopiazonic Acid, an Inhibitor of the Ca++ Atpase of Sarcoplasmic Reticulum, on Ca++ Transport, Contraction and Relaxation in Cardiac Muscle
Cyclopiazonic acid is a potent inhibitor of cardiac sarcoplasmic reticulum Ca++ ATPase. It scarcely affects inotropism but significantly impairs lusitropism suggesting a greater role for cardiac sarcoplasmic reticulum in the control of cardiac relaxation than in the control of cardiac contraction.
KeywordsSarcoplasmic Reticulum Negative Inotropic Effect Cardiac Contraction Cyclopiazonic Acid Cardiac Sarcoplasmic Reticulum
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