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[Ca2+] and [Na+] in Rat Ventricular Myocytes Showing Negative and Positive Force Frequency Relationships

  • James E. Frampton
  • Simon M. Harrison
  • Clive H. Orchard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Summary

Ventricular cells that show a positive force-frequency relationship show graded changes of intracellular [Ca2+] (Cai), [Na+] (Nai) and sarcoplasmic reticulum Ca2+ content with changes of stimulation frequency. Cells that show a negative force-frequency relationship show smaller changes of Nai and no change in the Ca2+ load of the sarcoplasmic reticulum as stimulation frequency is changed.

Keywords

Sarcoplasmic Reticulum Contractile Response Ventricular MYOCYTES Stimulation Frequency Force Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Capogrossi, M.C., Kort, A.A., Spurgeon, H.A. & Lakatta, E.G., 1986, J. Gen. Physiol., 88: 589–613.PubMedCrossRefGoogle Scholar
  2. Orchard, C.H. & Lakatta, E.G., 1985, J. Gen. Physiol. 86: 637–651.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • James E. Frampton
    • 1
  • Simon M. Harrison
    • 1
  • Clive H. Orchard
    • 1
  1. 1.Department of PhysiologyUniversity of LeedsUK

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