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Effect of Free Radicals on Excitation-Contraction Coupling in Isolated Rat and Guinea Pig Ventricular Myocytes

  • Magda Horackova
  • Andrzej Beresewicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Summary

Using the model of isolated myocytes, we have investigated under current- and/or voltage-clamp conditions: (i) the time-course of H2O2-induced changes in the action potentials and the contractility, (ii) the effect of pharmacological tools such as ryanodine, TTX and nifedipine on H2O2-induced changes; (iii) the effect H2O2 on ionic currents underlying the changes in APD; and (iv) the effect of deferoxamine on H2O2-induced changes.

Keywords

Electron Paramagnetic Resonance Action Potential Duration Rose Bengal Reperfusion Arrhythmia Early Afterdepolar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Magda Horackova
    • 1
  • Andrzej Beresewicz
    • 1
  1. 1.Department of Physiology and Biophysics Faculty of MedicineDalhousie UniversityHalifaxCanada

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