Effect of Free Radicals on Excitation-Contraction Coupling in Isolated Rat and Guinea Pig Ventricular Myocytes
Using the model of isolated myocytes, we have investigated under current- and/or voltage-clamp conditions: (i) the time-course of H2O2-induced changes in the action potentials and the contractility, (ii) the effect of pharmacological tools such as ryanodine, TTX and nifedipine on H2O2-induced changes; (iii) the effect H2O2 on ionic currents underlying the changes in APD; and (iv) the effect of deferoxamine on H2O2-induced changes.
KeywordsElectron Paramagnetic Resonance Action Potential Duration Rose Bengal Reperfusion Arrhythmia Early Afterdepolar
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