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Modulation of Ca2+ Release and Na+ Channel Function in Skeletal Muscle by Fatty Acids

  • Jeffrey E. Fletcher
  • Steven J. Wieland
  • Jill Beech
  • Terry D. Heiman-Patterson
  • Henrey Rosenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Summary

Ca2+- and halothane-induced Ca2+ release and Na+ currents are modulated by free fatty acids (FAs). FA modulation of ion currents may have important implications for general muscle physiology and skeletal muscle disorders, including malignant hyperthermia (MH).

Keywords

Human Skeletal Muscle Malignant Hyperthermia Malignant Hyperthermia Porcine Muscle Porcine2 Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Fletcher et al. Biochem. Cell Biol. (1990) 68:1195–1201.PubMedCrossRefGoogle Scholar
  2. 2.
    Wieland et al. (1991) In: Mechanisms of Anesthetic Action in Muscle (TJJ Blanck and DM Wheeler, eds) Plenum Publishing Corp., New York.Google Scholar
  3. 3.
    Wieland et al. (1989) Am. J. Physiol. 257:C759-C765.PubMedGoogle Scholar
  4. 4.
    Fletcher et al. (1990) Toxicon 28:647–656CrossRefGoogle Scholar
  5. 5.
    Fletcher et al. (1990) Biochem. Int. 21:733–740.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jeffrey E. Fletcher
    • 1
  • Steven J. Wieland
    • 1
  • Jill Beech
    • 2
  • Terry D. Heiman-Patterson
    • 3
  • Henrey Rosenberg
    • 1
  1. 1.Hahnemann UniversityPhiladelphiaUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA
  3. 3.Thomas Jefferson UniverisityPhiladelphiaUSA

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