NPY-(18–36) and Pertussis Toxin Distinguish between the Negative and Positive Contractile Effects of Neuropeptide Y (NPY) in Ventricular Cardiomyocytes

  • B. Cherie Millar
  • Barbara J. McDermott
  • H. Michael Piper
  • Ambikaipakan Balasubramaniam
  • Thomas Weis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


The mechanism of action of NPY to produce contractions of adult rat ventricular myocytes was investigated. Positive effects were mediated through an L-type Ca2+ channel. Negative effects, linked through an inhibitory G-protein to a transient outward K+ channel, could be antagonised by NPY-(18–36).


Adenylate Cyclase Contractile Response Adenosine Deaminase Pertussis Toxin cAMP Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • B. Cherie Millar
    • 1
  • Barbara J. McDermott
    • 1
  • H. Michael Piper
    • 2
  • Ambikaipakan Balasubramaniam
    • 3
  • Thomas Weis
    • 4
  1. 1.Department of Therapeutics and PharmacologyThe Queen’s University of BelfastUK
  2. 2.Physiologisches InstitutHeinrich-Heine-UniversitatDusseldorfGermany
  3. 3.Department of SurgeryUniversity of CincinnatiUSA
  4. 4.Pharmacologie InstitutHeinrich-Heine-UniversitatDusseldorfGermany

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