NPY-(18–36) and Pertussis Toxin Distinguish between the Negative and Positive Contractile Effects of Neuropeptide Y (NPY) in Ventricular Cardiomyocytes
The mechanism of action of NPY to produce contractions of adult rat ventricular myocytes was investigated. Positive effects were mediated through an L-type Ca2+ channel. Negative effects, linked through an inhibitory G-protein to a transient outward K+ channel, could be antagonised by NPY-(18–36).
KeywordsAdenylate Cyclase Contractile Response Adenosine Deaminase Pertussis Toxin cAMP Accumulation
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