Abstract
Urinary bladder contraction is mediated primarily via the stimulation of muscarinic receptors (1). The contractile response to bethanechol stimulation can be dissociated from the metabolic response through the use of diltiazem (calcium channel blockade) (2). KCl stimulates contraction in isolated strips by directly depolarizing the membrane rather than by binding to specific membrane receptors. The current study directly compares the metabolic and contractile activities of bethanechol (muscarinic stimulation) with KCl (direct membrane depolarization).
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© 1992 Springer Science+Business Media New York
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Levin, R.M., Hypolite, J., Longhurst, P.A., Wein, A.J. (1992). Energetics of Muscarinic Stimulation of Smooth Muscle. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_24
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_24
Publisher Name: Springer, Boston, MA
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