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Energetics of Muscarinic Stimulation of Smooth Muscle

  • Robert M. Levin
  • Joseph Hypolite
  • Penelope A. Longhurst
  • Alan J. Wein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

Urinary bladder contraction is mediated primarily via the stimulation of muscarinic receptors (1). The contractile response to bethanechol stimulation can be dissociated from the metabolic response through the use of diltiazem (calcium channel blockade) (2). KCl stimulates contraction in isolated strips by directly depolarizing the membrane rather than by binding to specific membrane receptors. The current study directly compares the metabolic and contractile activities of bethanechol (muscarinic stimulation) with KCl (direct membrane depolarization).

Keywords

Muscarinic Receptor Contractile Response Intracellular Free Calcium Calcium Channel Blockade Calcium Fluorescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1).
    Wein, A.J., Levin, R.M., and Barrett, D.M., Voiding Function: Relevant Anatomy, Physiology, and Pharmacology, in Adult and Pediatric Urology (Gillenwater, J.Y., Grayhack, J.T., Howards, S.S., and Ducken, J.D. eds.) Year Book Medical Publishers, Chicago, 1987, pp 933–1001.Google Scholar
  2. 2).
    Ruggieri, M.R., Wein, A.J., Hypolite, J.A., and Levin, R.M.: Dissociation of the metabolic from contractile response to muscarinic receptor stimulation in the rabbit urinary bladder. Mol. Cell. Biochem., 81: 137, 1988.PubMedCrossRefGoogle Scholar
  3. 3).
    Franke, H., Barlow, C.H., and Chance, B.: Surface fluorescence of reduced pyridine nucleotide of the perfused rat kidney: interrelation between metabolic and functional states. Contr. Nephrol., 19: 240, 1980.Google Scholar
  4. 4).
    Peterson, J.W.: Effect of histamine on the energy metabolism of K+-depolarized hog carotid artery. Circ. Res., 50: 848, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Robert M. Levin
    • 1
  • Joseph Hypolite
    • 1
  • Penelope A. Longhurst
    • 1
  • Alan J. Wein
    • 1
  1. 1.Division of UrologyHospital of the University of PennsylvaniaPhiladelphiaUSA

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