Energetics of Muscarinic Stimulation of Smooth Muscle
Urinary bladder contraction is mediated primarily via the stimulation of muscarinic receptors (1). The contractile response to bethanechol stimulation can be dissociated from the metabolic response through the use of diltiazem (calcium channel blockade) (2). KCl stimulates contraction in isolated strips by directly depolarizing the membrane rather than by binding to specific membrane receptors. The current study directly compares the metabolic and contractile activities of bethanechol (muscarinic stimulation) with KCl (direct membrane depolarization).
KeywordsMuscarinic Receptor Contractile Response Intracellular Free Calcium Calcium Channel Blockade Calcium Fluorescence
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