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nACh Receptor-Activity Modulating Intracellular Ca2+ (RAMIC); Its Finding, Properties and Roles

  • I. Kimura
  • H. Tsuneki
  • T. Kondoh
  • M. Kimura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

Noncontractile and contractile Ca2+ transients are observed simultaneously by nerve stimulation at neuromuscular synapse of mouse skeletal muscles in the presence of Cholinesterase inhibitors [1]. Noncontractile Ca2+ transients are more susceptible to n-acetylcholine receptor (nAChR) competitive blockers and external Ca2+ than contractile ones. We call the noncontractile ones “RAMIC” (receptor-activity modulating intracellular Ca2+). In this study, we elucidated the mechanisms of RAMIC, compared with those of contractile Ca2+ mobilization.

Keywords

Channel Blocker Cholinesterase Inhibitor Mouse Skeletal Muscle Neuromuscular Synapse Neuromuscular Blocking Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kimura I, Kondoh T and Kimura M. Postsynaptic nicotinic ACh receptor-operated Ca2+ transients with neostigmine in phrenic nerve-diaphragm muscles of mice. Brain Res. 507:309–311 (1989).CrossRefGoogle Scholar
  2. 2.
    Kimura I, Kondoh T and Kimura M. Changes in intracellular Ca2+ produced in the mouse diaphragm by neuromuscular blocking drugs. J. Pharm. Pharmacol. 42:626–631 (1990).PubMedCrossRefGoogle Scholar
  3. 3.
    Kimura M, Kimura I, Kondoh T and Tsuneki H. Noncontractile acetylcholine receptor-operated Ca++ mobilization: Suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle. J. Pharmacol. Exp. Ther. 256:18–23 (1991).PubMedGoogle Scholar
  4. 4.
    Kimura I, Kondoh T, Tsuneki H and Kimura M. Reversed effect of caffeine on noncontractile and contractile Ca2+ mobilization operated by acetylcholine receptor in mouse diaphragm muscle. Neurosci. Lett, (in press) (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • I. Kimura
    • 1
  • H. Tsuneki
    • 1
  • T. Kondoh
    • 1
  • M. Kimura
    • 1
  1. 1.Department of Chemical Pharmacology Faculty of Pharmaceutical SciencesToyama Medical and Pharmaceutical UniversityToyamaJapan

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