nACh Receptor-Activity Modulating Intracellular Ca2+ (RAMIC); Its Finding, Properties and Roles
Noncontractile and contractile Ca2+ transients are observed simultaneously by nerve stimulation at neuromuscular synapse of mouse skeletal muscles in the presence of Cholinesterase inhibitors . Noncontractile Ca2+ transients are more susceptible to n-acetylcholine receptor (nAChR) competitive blockers and external Ca2+ than contractile ones. We call the noncontractile ones “RAMIC” (receptor-activity modulating intracellular Ca2+). In this study, we elucidated the mechanisms of RAMIC, compared with those of contractile Ca2+ mobilization.
KeywordsChannel Blocker Cholinesterase Inhibitor Mouse Skeletal Muscle Neuromuscular Synapse Neuromuscular Blocking Drug
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