Mechanisms of Calcium Release from Terminal Cisternae in Crustacean Muscle
The chain of events leading to the release of Ca2+ from the terminal cisternae of the sarcoplasmic reticulum (SR) in vertebrate twitch skeletal muscle fibers begins with the action potential, which is propagated along the transverse tubular membrane (T tubules). The exact link between membrane potential changes in the T tubules (Heiny & Vergara, 1984) and Ca2+ release from the SR remains unresolved (Frank, 1980) despite the fact that the inward spread of mechanical activation has been measured (Costantin, 1975). Until recently, most of the experimental work on E-C coupling has been interpreted in terms of the direct electro-mechanical coupling hypothesis. In this model charged gating particles (Chandler, Rakowski & Schneider, 1976) control directly the release of Ca2+ from the SR (Hui & Gilly, 1979; Franzini-Armstrong, Block & Ferguson, 1990).
KeywordsSarcoplasmic Reticulum Skeletal Muscle Fiber Charge Movement Frog Skeletal Muscle Peak Tension
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- Arispe, N., Olivares, E., Jaimovich, E. & Rojas, E., 1991, Characteristics of Ca2+ release channels from crustacean skeletal muscle, J. Memb. Biol., in press.Google Scholar
- Bianchi, C. P. & Bolton, T.C., 1967, Action of local anesthetics on coupling systems in muscle, J. Pharmacol. Exp. Ther. 1957: 388–405.Google Scholar
- Franzini-Armstrong, C., Block, B. & Ferguson, D. G., 1990 A molecular architecture of T-SR junctions: Evidence for a junctional complex that directly connects the two membrane systems. In Transduction in Biological Systems. Eds. C. Hidalgo, J. Bacigalupo, E. Jaimovich & J. Vergara, Plenum Press, pp 339–360.CrossRefGoogle Scholar
- Luxoro, M. & Nassar-Gentina, V., 1984, Potassium-induced depolarizations and generation of tension in barnacle muscle fibers: Effects of external calcium, strontium, and barium. Quart. J. Exp. Physiol. 69: 235–243.Google Scholar
- Luxoro, M., Nassar-Gentina, V., Rojas, E., 1990, Excitation-contraction coupling in barnacle muscle fibers: Does calcium entry trigger contraction directly?. In Transduction in Biological Systems, Eds. C. Hidalgo, J. Bacigalupo, E. Jaimovich & J. Vergara, Plenum Press, pp.289–300.CrossRefGoogle Scholar
- Rojas, E., Forsberg, E. & Pollard, H.B., 1976, Optical detection of calcium dependent ATP release from stimulated medullary chromaffin cells. Adv. Exptl. Med. and Biol., 211: 7–28.Google Scholar