The Significance of Na+ in E-C Coupling in Muscle

  • Vladimir Nesterov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


A great diversity of forms of multicellular organisms having come into being during animal evolution has determined the exclusively structural and functional variety of their muscles differing, particularly, in their mode of activation. In vertebrate twitch muscles a crucial step in excitation- contraction (E-C) coupling concerns the mechanisms whereby the electrical activity of the T-tubular membrane (TTM) induces the release of Ca2+ from the sarcoplasmic reticulum (SR). The investigation of this key question of the E-C coupling has resulted in two principal hypotheses about the nature of the T-SR signal transmission: (i) Ca2+ release from SR triggered by a change in tubular membrane polarization and (ii) Ca2+ release induced by specific chemical transmitter from the T-system.


Skeletal Muscle Sarcoplasmic Reticulum Skeletal Muscle Fiber Charge Movement Contraction Coupling 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Vladimir Nesterov
    • 1
  1. 1.Sechenov Institute of Evolutionary Physiology and BiochemistryLeningradUSSR

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