Role of Calcium Channels of the Sarcolemma and the Sarcoplasmic Reticulum in Skeletal Muscle Functions

  • C. Paul Bianchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


Calcium channels of the sarcolemma and the sarcoplasmic reticulum play a key integrative role in determining and fine tuning the ionic free calcium concentration of the sarcoplasm and regulation of muscle function. Changes in the free ionic calcium concentration can lead to (1) force development and motion, (2) heat production during fever, and (3) breakdown of muscle protein reserves.


Sarcoplasmic Reticulum Calcium Influx Extractable Calcium Transverse Tubule Dihydropyridine Receptor 
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  1. Adams, B., Tanabe, T., Mikami, A., Numa, S., and Beam, K.G., 1990, Intramembrane chargemovement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs, Nature, 346: 569–572.PubMedCrossRefGoogle Scholar
  2. Bianchi, C.P. and Shanes, A.M., 1959, Calcium influx in skeletal muscle at rest, during activityand during potasium contracture, J. Gen. Physiol., 42: 803–815.PubMedCrossRefGoogle Scholar
  3. Bianchi, C.P. and Narayan, S.R., 1982, Muscle fatigue and the role of Transverse Tubules, Science, 215: 295–296.PubMedCrossRefGoogle Scholar
  4. Bianchi, C.P. and Narayan, S.R., 1984, Effect of diazepam on calcium translocation during physiological muscle fatigue, J. Pharmacol. Exp. Ther., 231: 197–205.PubMedGoogle Scholar
  5. Bianchi, C.P., 1990, Endogenous “Ryanodine agonist and hyperthermia”, Life Sciences, 47: PL23–PL24.PubMedCrossRefGoogle Scholar
  6. Fabiato, A., 1985, Effect of ryanodine in skinned cardiac cells, Fed. Proc, 44: 2970–2976.PubMedGoogle Scholar
  7. Hoffman, E.P., Knudson, C.M., Campbell, K.P. and Kunkel, L.M., 1987, Subcellular fractionation of dystrophin to the triads of skeletal muscle, Nature, 330: 754–758.PubMedCrossRefGoogle Scholar
  8. Ikemoto, N., Ronjat, M., Meszaros, L.G. and Koshita, M., 1989, Postulated role of calsequestrin in the regulation of calcium release from sarcoplasmic reticulum, Biochem., 28: 6764–6771.CrossRefGoogle Scholar
  9. Ikemoto, N., Antonia, B., Kang, J.J., Meszaros, L.G., and Ronjat, M., 1991, Intravesticular calcium transient during calcium release from sarcoplasmic reticulum, Biochemistry, 30: 5230–5237.PubMedCrossRefGoogle Scholar
  10. Imazawa, T., Smith, J.S., Coronado, R., and Campbell, K.P., 1987, Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel, J. Biol. Chem., 262: 16636–16643.Google Scholar
  11. Lakatta, E.G. and Henderson, J.S., 1985, Spontaneous myocardial calcium oscillations: overview with emphasis on ryanodine and caffeine, Fed. Proc., 44: 2977–2983.PubMedGoogle Scholar
  12. Lopez, L.R., Alamo, L., Caputo, C., DiPolo, R. and Vergara, J., 1983, Determination of ionic calcium in frog skeletal muscle fibers, Biophys. J., 453: 1–4.CrossRefGoogle Scholar
  13. Rios, E. and Pizarro, G., 1988, Voltage sensors and calcium channels of excitation-contraction coupling, New in Physiological Sciences, 3: 223–227.Google Scholar
  14. Somlyo, A.V., Kitazawa, T., Gonzalez-Serratos, H., McClellan, G. and Somlyo, A.P., 1985, Ion movements associated with calcium release and uptake in the sarcoplasmic reticulum, In: Calcium in Biological Systems, R.P. Rubin, G.B. Weiss and J.W. Putney, ed., pp. 351–358, Plenum Press, New York.CrossRefGoogle Scholar
  15. Tanabe, T., Beam, K.G., Adams, B., Nudome, T. and Numa, S., 1990, Regions of the skeletal muscle dihyphopyridine receptor critical for excitation-contraction coupling, Nature, 346: 567–569.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • C. Paul Bianchi
    • 1
  1. 1.Dept. of Pharmacology, Jefferson Medical CollegeThomas Jefferson UniversityPhiladelphiaUSA

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