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Calcium Release and Force Development in Rat Myocardium

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Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 311))

Abstract

It is well known that cardiovascular control mechanisms which adjust cardiac output to the bloodflow required by the organs in the body continuously modulate force of the heartbeat. The balance between the vagal and sympathetic activities dictates the heart rate, and hence through the force-frequency and force-interval relationships the contractile state of the heart. In addition, adrenergic transmitters and hormones control both calcium transport and the sensitivity of the contractile filaments to calcium ions in the myocyte by their modulation of phosphorylation of calcium channels, calcium pumps and troponin-I. Adjustment of the venous tone by the cardiovascular control mechanisms dictates the work put out by the heart through the mechanism described by Starling, that the change of venous and hence end-diastolic pressure which results from activation of the control system leads to a change in stretch of the cardiac sarcomeres and thereby an increase or decrease of the response of the contractile filaments to calcium ions.

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Author information

Authors and Affiliations

  1. Department of Medicine and Medical Physiology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, T2N 4N1, Canada

    H. E. D. J. ter Keurs, P. H. Backx, H. Banijamali, B. MacIntosh & W. D. Gao

Authors
  1. H. E. D. J. ter Keurs
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  2. P. H. Backx
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  3. H. Banijamali
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  4. B. MacIntosh
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  5. W. D. Gao
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Editor information

Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    George B. Frank

  2. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    C. Paul Bianchi

  3. University of Calgary, Calgary, Alberta, Canada

    Henk E. D. J. ter Keurs

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© 1992 Springer Science+Business Media New York

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ter Keurs, H.E.D.J., Backx, P.H., Banijamali, H., MacIntosh, B., Gao, W.D. (1992). Calcium Release and Force Development in Rat Myocardium. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3362-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6483-2

  • Online ISBN: 978-1-4615-3362-7

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