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Calcium Release and Force Development in Rat Myocardium

  • H. E. D. J. ter Keurs
  • P. H. Backx
  • H. Banijamali
  • B. MacIntosh
  • W. D. Gao
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)

Abstract

It is well known that cardiovascular control mechanisms which adjust cardiac output to the bloodflow required by the organs in the body continuously modulate force of the heartbeat. The balance between the vagal and sympathetic activities dictates the heart rate, and hence through the force-frequency and force-interval relationships the contractile state of the heart. In addition, adrenergic transmitters and hormones control both calcium transport and the sensitivity of the contractile filaments to calcium ions in the myocyte by their modulation of phosphorylation of calcium channels, calcium pumps and troponin-I. Adjustment of the venous tone by the cardiovascular control mechanisms dictates the work put out by the heart through the mechanism described by Starling, that the change of venous and hence end-diastolic pressure which results from activation of the control system leads to a change in stretch of the cardiac sarcomeres and thereby an increase or decrease of the response of the contractile filaments to calcium ions.

Keywords

Muscle Length Sarcomere Length Calcium Transient Terminal Cisterna Intracellular Calcium Transient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    de Tombe PP, ter Keurs HEDJ. Force and velocity of sarcomere shortening in trebeculae from rat heart. Effects of temperature. Circ Res 66:1239–1254 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    Daniels MCG, Fedida D, Lamont C, ter Keurs HEDJ. Role of the sarcolemma in triggered propagated contractions in rat cardiac trabeculae. Circ Res 68:1408–1421 (1991).PubMedCrossRefGoogle Scholar
  3. 3.
    Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescent properties. J Biol Chem 260:3440 (1985).PubMedGoogle Scholar
  4. 4.
    Van Heuningen R, Rijnsburger WH, ter Keurs HEDJ. Sarcomere length control in striated muscle. Am J Physiol 242:H411–H420 (1982).PubMedGoogle Scholar
  5. 5.
    Allen DG, Blinks JR. Calcium transients in aequorin -injected frog cardiac muscle. Nature 273:509–513 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    Wier WG, Yue DT. Intracellular calcium transients underlying the short term force-interval relationship in ferret myocardium. J Physiol 376:507–530 (1986).PubMedGoogle Scholar
  7. 7.
    Allen DG, Kurihara S. Calcium transients in mammalian ventricular muscle. Eur Heart J 1:5–15 (1980).Google Scholar
  8. 8.
    Spurgeon HA, Baartz G, Capogrossi MC, Raffaeli S, Stern M, Lakatta EG. The relationship between the cytosolic Ca2+ transient and cell length during a twitch in single adult cardiac myocytes, in: Biology of Isolated Adult Cardiac Myocytes. Editors: WA Clark, RS Decker, Borg TK. Elsevier Press, New York. pp350–353 (1988).Google Scholar
  9. 9.
    Krueger JW. Measurement and interpretation of contraction in isolated cardiac cells. In: Biology of Isolated Adult Cardiac Myocytes. Editors: WA Clark, RS Decker, Borg TK. Elsevier Press, New York, pp 172–186 (1988).Google Scholar
  10. 10.
    Housmans PR. The relation between contraction dynamics and intracellular calcium transient in mammalian cardiac muscle. In: Starling’s Law of the Heart Revisited. Editors: HEDJ ter Keurs and MIM Noble. Kluwer Press, Dordrecht, pp 60–66 (1988).CrossRefGoogle Scholar
  11. 11.
    duBell WH, Philips CM, Houser SR. A technique for measuring cytosolic free Ca2+ with Indo-1 in feline myocytes, in: Biology of Isolated Adult Cardiac Myocytes. Editors: WA Clark, RS Decker and TK Borg. Elsevier Publishing, New York. ppl87–201 (1988).Google Scholar
  12. 12.
    Lee H, Mohabir R, Smith N, Franz MR, Clusin WT. Effect of ischemia on calcium dependent fluorescence transients in rabbit hearts containing Indo-1. Circ Res 1988;78:1047–1059.Google Scholar
  13. 13.
    Hibberd MG, Jewell BR. Calcium and length-dependent force production in rat ventricular muscle. J Physiol 329:527–540 (1982).PubMedGoogle Scholar
  14. 14.
    Kentish JC, ter Keurs HEDJ, Ricciardi,L, Bucx JJJ, Noble MIM. Comparison between the sarcomere length-force relations of intact and skinned cardiac trabeculae from rat right ventricle. Circ Res 58:755–786 (1986).PubMedCrossRefGoogle Scholar
  15. 15.
    Hofmann PA, Fuchs F. Bound calcium and force development in skinned cardiac muscle bundles: effect of sarcomere length. J Mol Cell Cardiol 20:667–677 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    Babu A, Sonnenblick E., Gulati J. Molecular basis for the influence of muscle length on myocardial performance. Science 240:74–76 (1988).PubMedCrossRefGoogle Scholar
  17. 17.
    Schouten, V.J.A., Van Deen, J.K., de Tombe, P.P., Verveen, A.A. Force-interval relationship in heart muscle of mammals: A calcium compartment model. Biophvs J 51:13–26 (1987).CrossRefGoogle Scholar
  18. 18.
    Bridge, J.H.B. Relationships between the sarcoplasmic reticulum and transsarcolemmal Ca transport revealed by rapidly cooling rabbit ventricular muscle. J Gen Physiol 88:437–473 (1986).PubMedCrossRefGoogle Scholar
  19. 19.
    Allen, D.G., Jewell, B.R., Wood, E.H. Studies on the contractility of mammalian myocardium at low rates of stimulation. J Physiol 254:1–17 (1976).PubMedGoogle Scholar
  20. 20.
    Shattock, M.J., Bers, D.M. Rat vs. rabbit ventricle: Ca influx and intracellular Na assessed by ion-selective microelectrodes. Am J Physiol 256:C813–C822 (1989).PubMedGoogle Scholar
  21. 21.
    Sitsapesan, R., Montgomery, R.A.P., MacLeod, K.T., Williams, A.J. Increased open probability of sheep cardiac sarcoplasmic reticulum calcium release channels induced by low temperatures. Proceedings of the Physiological Society. March 1990. 28p.Google Scholar
  22. 22.
    Bers, D.M., Bridge, J.H.B., Spitzer, K.W. Intracellular calcium transients during rapid cooling contractures in guinea-pig ventricular myocytes. J Physiol Lond 417:537–553 (1989).PubMedGoogle Scholar
  23. 23.
    Bers, D.M. SR calcium loading in cardiac muscle preparations based on rapid cooling contractures. Am J Physiol 256:C109–C120 (1989).PubMedGoogle Scholar
  24. 24.
    Harrison, S.M., Bers, D.M. Temperature dependence of myofilament calcium sensitivity of rat, guinea-pig, and frog ventricular muscle. Am J Physiol 258:C274–C281 (1990).PubMedGoogle Scholar
  25. 25.
    Kurihara, S., Sakai, T. Effects of rapid cooling on mechanical and electrical responses in ventricular muscle of guinea-pig. J Physiol Lond 361:361–378 (1985).PubMedGoogle Scholar
  26. 26.
    Dani, A.M., Cittadini, A, Inesi, G. Calcium transient and contractile activity in dissociated mammalian heart cells. Am J Physiol 237:C147–C155 (1979).PubMedGoogle Scholar
  27. 27.
    Bers, D.M., Bridge, J.H.B. Relaxation of rabbit ventricular muscle by Na/Ca exchange and SR calcium pump- Ryanodine and voltage-sensitivity. Circ Res 65:334–342 (1989).PubMedCrossRefGoogle Scholar
  28. 28.
    Bers, D.M., Bridge, J.H.B., MacLeod, K.T. The mechanism of ryanodine action in rabbit ventricular muscle evaluated with Ca-selective microelectrodes and rapid cooling contractures. Can J Physiol and Pharmacol 65:610–618 (1987).CrossRefGoogle Scholar
  29. 29.
    Bers, D.M., Bridge, J.H.B. Effect of acetylstrophanthidin on twitches, microscopic tension fluctuations and cooling contractures in rabbit ventricle. J Physiol Lond 404:53–69 (1988).PubMedGoogle Scholar
  30. 30.
    Hryshko, L.V. Stiffel, V., Bers, D.M. Rapid cooling contractures as an index of SR calcium content in rabbit ventricular myocytes. Am J Physiol 257:H1369–H1377 (1989).PubMedGoogle Scholar
  31. 31.
    Fabiato, A Stimulated calcium current can both cause calcium loading and trigger calcium release from the sarcoplasmic reticulum of skinned cardiac Purkinje cells. J Gen Physiol 85:291–320 (1985).PubMedCrossRefGoogle Scholar
  32. 32.
    Inui, M., Saito, A., Fleischer, S. Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum identified with the feet structures. J Biol Chem 262:15637–15642 (1987).PubMedGoogle Scholar
  33. 33.
    Inui, M., Saito, A., Fleischer, S. Purification of the ryanodine receptor and identification with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle. J Biol Chem 262:1740–1747 (1987).PubMedGoogle Scholar
  34. 34.
    Nabauer, M. Callewaert, G., Cleemann, L., Morad, M. Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science 244:800–803 (1989).PubMedCrossRefGoogle Scholar
  35. 35.
    Morad, M., Cleeman, L. The role of Ca2+ channel in development of tension in heart muscle. J Mol Cell Cardiol 19:527–553 (1987).CrossRefGoogle Scholar
  36. 36.
    Antoni, H., Jacob, R., Kaufmann, R. Mechanische Reaktionen des Frosch- und Saeugetiermyokards bei Veraenderung der Aktionpotential-Dauer durch konstante Gleichstromimpulse. Pfluegers Arch 306:33–57 (1969).CrossRefGoogle Scholar
  37. 37.
    Bers, D.M. Early transient depletion of extracellular calcium during individual cardiac muscle contractions. Am J Physiol 244:H462–H468 (1983).PubMedGoogle Scholar
  38. 38.
    Josephson, J., Sanchez-Chapula, J., Brown, A.M. A comparison of calcium currents in rat and guinea pig single ventricular cells. Circ Res 54:144–156 (1984).PubMedCrossRefGoogle Scholar
  39. 39.
    Tseng, G.N. Calcium current restitution in mammalian ventricular myocytes is modulated by intracellular calcium. Circ Res 63:468–482 (1988).PubMedCrossRefGoogle Scholar
  40. 40.
    Schouten, V.J.A. The negative correlation between action potential duration and force of contraction during restitution in rat myocardium. J Mol Cell Card 18:1033–1045 (1986).CrossRefGoogle Scholar
  41. 41.
    Ragnarsdottir, K., Wohlfart, B., Johansson, M. Mechanical restitution in rat papillary muscle. Acta Physiol Scand 115:183–191 (1982).PubMedCrossRefGoogle Scholar
  42. 42.
    Quagebeur, J.M. Schouten, V.J.A., ter Keurs, H.E.D.J. Mechanical restitution in human myocardium. J Physiol 377:120p (1986).Google Scholar
  43. 43.
    Kitazawa, T. Effect of extracellular calcium on contractile activation in guinea-pig ventricular muscle. J Physiol Lond 355:635–659 (1984).PubMedGoogle Scholar
  44. 44.
    Hilgemann, D.W. Extracellular calcium transients and action potential configuration changes related to post-stimulatory potentiation in rabbit atrium. J Gen Physiol 87:675–706 (1986).PubMedCrossRefGoogle Scholar
  45. 45.
    Bers, D.M., MacLeod, K.T. Cumulative extracellular calcium depletions in cardiac muscle. Circ Res 58:769–782 (1986).PubMedCrossRefGoogle Scholar
  46. 46.
    Sagawa K, Maughan L, Suga H, Sunagawa K. Energetics of the Heart, In: Cardiac Contraction and the Pressure-Volume Relationship. Oxford University Press, pp 171–231 (1988).Google Scholar
  47. 47.
    Gao WD, ter Keurs HEDJ. Determinants of ATP depletion during metabolic inhibition of rat cardiac muscle. Canadian Cardiovascular Society Meeting (abstract) 1991.Google Scholar
  48. 48.
    Banijamali HS, Gao WD, MacIntosh BR, ter Keurs HEDJ. The force-interval relationships of twitches and cold contractures in rat cardiac trabeculae: the effect of ryanodine. Circ Res (in press) 1991.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • H. E. D. J. ter Keurs
    • 1
  • P. H. Backx
    • 1
  • H. Banijamali
    • 1
  • B. MacIntosh
    • 1
  • W. D. Gao
    • 1
  1. 1.Department of Medicine and Medical PhysiologyUniversity of CalgaryCalgaryCanada

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