Subcellular Calcium Compartmentation and Exchange in the Cardiac Cell: Relation to Contractile Control

  • Glenn A. Langer
  • Terrell L. Rich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


It is the ultimate goal of studies underway at the UCLA Cardiovascular Research Laboratory to identify, in the intact functional cell, the content and exchange characteristics of the calcium (Ca) in the various subcellular organelles. Until this is done a final, comprehensive model of excitation-contraction coupling processes as they perform and interrelate in vivo cannot be realized.


Sarcoplasmic Reticulum Calcium Release Channel Compartment Size Intermediate Compartment Cardiac Sarcolemma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    G. A. Langer, T. L. Rich and F. B. Orner, Ca exchange under non-perfusion limited conditions in rat ventricular cells: Identification of subcellular compartments. Am. J. Physiol. 259:H592–H602 (1990)PubMedGoogle Scholar
  2. 2.
    A. L. Lehninger, Role of phosphate and other protondonating anions in respiration-coupled transport of Ca2+ by mitochondria. Proc. Natl. Acad. Sci. USA 71:1520–1524 (1974)PubMedCrossRefGoogle Scholar
  3. 3.
    M. Crompton, The role of Ca2+ in the function and dysfunction of heart mitochondria, in: “Calcium and the Heart”, G.A. Langer, ed. Raven Press, New York (.1990) pp. 167–198Google Scholar
  4. 4.
    L. G. Walsh and J. McD. Tormey, Cellular compartmentation in ischemic myocardium: indirect analysis by electron probe. Am. J. Physiol. 255:H929–H936 (1988)PubMedGoogle Scholar
  5. 5.
    E. Rousseau, and G. Meissner, Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine. Am. J. Physiol. 256:H328–H333 (1989)PubMedGoogle Scholar
  6. 6.
    K. Ondrias, L. Borgatta, D. H. Kim and B.E. Ehrlich, Biphasic effects of doxorubicin on the calcium release channel from sarcoplasmic reticulum of cardiac muscle. Circ. Res. 67:1167–1179 (1990)PubMedCrossRefGoogle Scholar
  7. 7.
    J. A. Post and G. A. Langer, Molecular origin of sarcolemmal calcium binding sites. FASEB J. 5:A1051 (1991)Google Scholar
  8. 8.
    J. A. Post, G. A. Langer, J. A. F. Op den Kamp and A. J. Verkleij, Phospholipid asymmetry in cardiac sarcolemma. Analysis of intact cells and “gasdissected” membranes. Biochim. Biophys. Acta 943: 256–266 (1988)PubMedCrossRefGoogle Scholar
  9. 9.
    J. H. B. Bridge, J. R. Smolley and K. W. Spitzer, The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science 248:376–378 (1990)PubMedCrossRefGoogle Scholar
  10. 10.
    L. M. Crespo, C. J. Grantham and M. B. Cannell, Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes. Nature 345:618–621 (1990)PubMedCrossRefGoogle Scholar
  11. 11.
    T. L. Rich and G. A. Langer, Na-Ca exchange contribution to the “rapid” exchangeable Ca compartment of rat heart cells. FASEB J. 5: Part II, A1051 (1991)Google Scholar
  12. 12.
    A. Weber, The mechanism of action of caffeine on sarcoplasmic reticulum. J. Gen. Physiol. 52:760–772 (1968)PubMedCrossRefGoogle Scholar
  13. 13.
    K. Nagasaki and S. Fleischer, Ryanodine sensitivity of the calcium release channel of sarcoplasmic reticulum. Cell Calcium 9:1–7 (1988)PubMedCrossRefGoogle Scholar
  14. 14.
    B. Lewartowski, R. G. Hansford, G. A. Langer, E. G. Lakatta, Contraction and sarcoplasmic reticulum Ca2+ content in single myocytes of guinea pig heart: effect of ryanodine. Am. J. Physiol. 259:H1222–H1229 (1990)PubMedGoogle Scholar
  15. 15.
    E. Carafoli, Sarcolemmal calcium pump, in: “Calcium in the Heart”, G. A. Langer, ed., Raven Press, New York (1990) pp. 109–126Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Glenn A. Langer
    • 1
  • Terrell L. Rich
    • 1
  1. 1.Cardiovascular Research LaboratoryUCLA School of MedicineLos AngelesUSA

Personalised recommendations