Abstract
Organic Ca2+ antagonists are specific substances which interfere with the gating of Ca2+ channels. They are of great interest as they are effective drugs in the therapy of different heart diseases. At present one distinguishes between three main classes of Ca2+ antagonists: dihydropyridines (DHPs), phenylalkylamines (PAAs) and benzothiazepines (BTZs). These classes appear to have different binding sites at the Ca2+ channel which show a reciprocal allosteric interaction among each other and with additional Ca2+ binding sites (Glossmann et al., 1985).
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Lüttgau, H.C., Böhle, T., Schnier, A. (1992). Ca2+ Antagonists as Tools in the Analysis of Excitation-Contraction Coupling in Skeletal Muscle Fibres. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_11
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_11
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