Ca2+ Antagonists as Tools in the Analysis of Excitation-Contraction Coupling in Skeletal Muscle Fibres

  • H. Ch. Lüttgau
  • Th. Böhle
  • A. Schnier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 311)


Organic Ca2+ antagonists are specific substances which interfere with the gating of Ca2+ channels. They are of great interest as they are effective drugs in the therapy of different heart diseases. At present one distinguishes between three main classes of Ca2+ antagonists: dihydropyridines (DHPs), phenylalkylamines (PAAs) and benzothiazepines (BTZs). These classes appear to have different binding sites at the Ca2+ channel which show a reciprocal allosteric interaction among each other and with additional Ca2+ binding sites (Glossmann et al., 1985).


Skeletal Muscle Fibre Voltage Sensor Charge Movement Single Muscle Fibre Conditioning Pulse 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • H. Ch. Lüttgau
    • 1
  • Th. Böhle
    • 1
  • A. Schnier
    • 1
  1. 1.Department of Cell PhysiologyRuhr-University of BochumBochumGermany

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