Na/Ca Exchange and First Messenger Ca in Skeletal Muscle Excitation - Contraction Coupling
Depolarization initiates a process in the wall of the transverse tubular system (t system). This process gives rise to a transient electrical signal - charge movement - which is closely linked to the release of Ca from the sarcoplasmic reticulum (SR) via the foot process. Two types of linkage have been discussed at this Conference: 1) structural links spanning the t-SR gap, such as the rigid rod model (Schneider and Chandler, 1973), and 2) chemical links including trigger Ca (Bianchi, 1969 and Frank, 1980).
KeywordsSarcoplasmic Reticulum Charge Movement Frog Skeletal Muscle Sarcolemmal Vesicle Influx Period
Unable to display preview. Download preview PDF.
- Fabiato, A., 1984, Dependence of the Ca2+-induced release from the sarcoplasmic reticulum of skinned skeletal muscle fibres from the frog semitendinosus on the rate of change of free Ca2+ concentration at the outer surface of the sarcoplasmic reticulum, J. Physiol., 353:56P.Google Scholar
- González, S., Brum, G., and Pizarro, G., 1991, Effects of procaine on calcium release in skeletal muscle fibers, Biophys. J. 59:62a.Google Scholar
- Li, Z., Nicoll, D. A., Collins, A., Hilgemann, D. W., Filoteo, A. G., Penniston, J. T., Tomich, J. M., and Philipson, K. D., 1991, Identification of a peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+ exchanger, Biophys. J., 59:138a.Google Scholar
- Luttgau, H. C., 1963, The action of calcium ions on potassium contractures of single muscle fibres, J. Physiol., 168:679–697.Google Scholar
- Schwartz, L. M., McCleskey, E. W., and Almers, W., Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels, Nature, 314:747–750.Google Scholar
- Sheu, S-S., and Blaustein, M. P., 1986, Sodium/calcium exchange and regulation of cell calcium and contractility in cardiac muscle, with a note about vascular smooth muscle, in: H. A. Fozzard et al., eds., The Heart and Cardiovascular System, New York: Raven Press, Ch. 26.Google Scholar
- Watson, P. T., and Winegrad, S., 1973, A possible sodium-calcium exchange in skeletal muscle, Fed. Proc., 32:374, Abst.Google Scholar