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Radiation Induces Changes in Glycosaminoglycans of Endothelial Cells

  • D. Pye
  • S. Kumar
  • J. Gallagher
  • R. Hunter
Part of the NATO ASI Series book series (NSSA, volume 227)

Abstract

Proteoglycans (PGs) are macromolecules found widely distributed in animal tissues principally in the extracellular matrix (ECM) and cell surface memebranes. A PG is a glycoprotein consisting of a protein core, linked to which are one or more sulphated polysaccharide chains, glycosaminoglycans (GAGs). We have observed that X-irradiation of bovine aortic endothelial cells in culture result in either changes in GAG production levels or molecular organization or both. A variety of techniques including chromatography and electrophoresis can be employed to elucidate structural changes in the GAGs, which may occur on irradiation of BAEC. In particular one type of GAG heparan sulphate, is under study and shows promise as a biological indicator of radiation induced damage to endothelial cells during radiotherapy.

Keywords

Endothelial Cell Cancer Patient Structural Change Extracellular Matrix Body Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • D. Pye
    • 1
  • S. Kumar
    • 1
  • J. Gallagher
    • 1
  • R. Hunter
    • 1
  1. 1.Christie Hospital ManchesterEngland

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