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Brain Tumor Angiogenesis: Drug Delivery and New Inhibitors

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Angiogenesis in Health and Disease

Part of the book series: NATO ASI Series ((NSSA,volume 227))

Abstract

Despite enormous advances in clinical medicine, the prognosis of primary malignant brain neoplasms remains dismal. Currently, the most effective therapies result in a median survival of less than one year, with the majority of patients dying within two years (Black, 1991). In order to develop more effective methods for combatting this disease, we took advantage of two biological properties that are critical to glioma growth: first, the observation that malignant gliomas are predominantly a local disease usually recurring within two centimeters of the original focus (Hochberg and Pruitt, 1980); and second, the increasing evidence that brain tumors, like most solid tumors, are angiogenesis-dependent (Brem, et. al., 1988).

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Author information

Authors and Affiliations

  1. Departments of Neurosurgery, Oncology, and Opthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Christopher Guerin, Rafael J. Tamargo, Alessandro Olivi & Henry Brem

Authors
  1. Christopher Guerin
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  2. Rafael J. Tamargo
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  3. Alessandro Olivi
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  4. Henry Brem
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Editor information

Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Turin Medical School, Turin, Italy

    Pietro Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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© 1992 Springer Science+Business Media New York

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Guerin, C., Tamargo, R.J., Olivi, A., Brem, H. (1992). Brain Tumor Angiogenesis: Drug Delivery and New Inhibitors. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_24

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  • DOI: https://doi.org/10.1007/978-1-4615-3358-0_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6481-8

  • Online ISBN: 978-1-4615-3358-0

  • eBook Packages: Springer Book Archive

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