Angiogenesis and Neoplastic Transformation
The major symptom of the neoplastic diseases is the unrestrained growth of cell populations with formation in most cases of solid tumors. Passage of cells into circulation and metastases formation completes the lethal outcome of the disease. When an agglomerate of cells is being formed in vivo, the increment in volume is conditioned by the supply system that sustains the metabolic needs. Thus, tumor formation requires not only the presence of a neoplastic cell population but also the participation of the host tissues supplying the vascular network. If this does not occur, the formation or growth of a solid tumor does not occur either. The validity of this conclusion was demonstrated several years ago1.
KeywordsMammary Gland Neoplastic Transformation Neoplastic Tissue Angiogenic Response Preneoplastic Lesion
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