Production of Plasminogen Activators and Matrix Metalloproteinases by Endothelial Cells: Their Role in Fibrinolysis and Local Proteolysis

  • Victor W. M. van Hinsbergh
  • Pieter Koolwijk
Part of the NATO ASI Series book series (NSSA, volume 227)


Matrices composed of fibrous proteins play an important role in the growth and repair of tissues. The complex extracellular matrix not only anchors the cell in the body, but it also provides the cell - via interaction with receptors and the cytoskeleton - with information about its position in the tissue. Various proteases, in particular plasmin, plasminogen activators (PAs) and matrix degrading metalloproteinases (MMPs) are involved in the regulation of the turnover and destruction of such matrices [Daneø et al., 1985; Saksela, 1985; Mignatti et al., 1986; Liotta et al., 1991].


Plasminogen Activator Plasminogen Activator Inhibitor Phorbol Ester Human Endothelial Cell Capillary Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Victor W. M. van Hinsbergh
    • 1
  • Pieter Koolwijk
    • 1
  1. 1.Gaubius LaboratoryIVVO-TNOLeidenThe Netherlands

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