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Combination Therapies pp 237–244Cite as

Synergistic Regulation of Lak Lymphocyte Cytotoxicity by Combination Cytokine and Cisplatin Treatment

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Abstract

The purpose of this investigation is to define if combination lymphokine and chemotherapeutic drug treatment can enhance the sensitivity of human papillomavirus (HPV) DNA immortalized dysplastic and HPV DNA containing cervical carcinoma cells to destruction by natural killer (NK) and lymphokine activated killer (LAK) lymphocytes. Human papilloma viruses infect squamous epithelium and are associated with the development of benign and malignant epithelial tumors.1–3 HPV type 16 is a suspected etiologic agent in the pathogenesis of cervical intraepithelial dysplasia and malignancy.4 In most premalignant and benign cervical lesions, HPV DNA exists in an episomal form, while in cervical cancers it is found integrated into the cellular genome.5 The cell-mediated effector arm of the immune response may have a key role in host defense against HPV infection and the possible development of neoplastia. Support for this is the presence of T lymphocytes, and the absence of a significant number of B lymphocytes, in cervical metaplasia and in normal cervical epithelium.6 However, in HPV infections and cervical intraepithelial neoplasia there is a general depletion of intraepithelial T lymphocytes with T4+ helper lymphocytes being more depleted than T8+ suppressor lymphocytes.6

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Author information

Authors and Affiliations

  1. Laboratory of Biology, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Charles H. Evans, Paulette M. Furbert-Harris, Anath A. Flugelman, Craig D. Woodworth & Joseph A. DiPaolo

Authors
  1. Charles H. Evans
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  2. Paulette M. Furbert-Harris
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  3. Anath A. Flugelman
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  4. Craig D. Woodworth
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  5. Joseph A. DiPaolo
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Editor information

Editors and Affiliations

  1. The George Washington University School of Medicine, Washington, D.C., USA

    Allan L. Goldstein

  2. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

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© 1992 Springer Science+Business Media New York

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Evans, C.H., Furbert-Harris, P.M., Flugelman, A.A., Woodworth, C.D., DiPaolo, J.A. (1992). Synergistic Regulation of Lak Lymphocyte Cytotoxicity by Combination Cytokine and Cisplatin Treatment. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_29

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  • DOI: https://doi.org/10.1007/978-1-4615-3340-5_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6472-6

  • Online ISBN: 978-1-4615-3340-5

  • eBook Packages: Springer Book Archive

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