Abstract
Successful immunotherapy of human cancer requires the induction of a cell-mediated immune response to weakly immunogenic tumor-associated antigens. To accomplish that aim, we have used two immunological strategies, each of which is based on well-established findings in experimental animals.
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Berd, D., Maguire, H.C., McCue, P., and Mastrangelo, M.J., 1990, Treatment of metastatic melanoma with an autologous tumor cell vaccine: Clinical and immunological results in 64 patients. J. Clin. Oncol., 8: 1858–1867.
Berd, D., Maguire, H.C. Jr., Mastrangelo, M.J., 1986, Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Res. 46:2572–2577.
Fujiwara, H., Aoki, H., Yoshioka, T., Tomita, S., Ikegami, R., and Hamaoka, T., 1984, Establishment of a tumor-specific immunotherapy model utilizing TNP- reactive helper cell activity and its application to the autochthonous tumor system, J. Immunol., 133: 509–514.
Maguire, H.C. and Ettore, V.L., 1967, Enhancement of dinitrochlorobenzene (DNCB) contact sensitization by cyclophosphamide in the guinea pig. J. Invest. Dermatol., 48:39–42.
Mitchison, N.A., 1970, Immunologic approach to cancer. Transplant. Proc., 11: 92–103.
Peters, L.C., Brandhorst, J.S., Hanna, M.G. Jr., 1979, Preparation of immunotherapeutic autologous tumor cell vaccines from solid tumors. Cancer Res. 39:1353–1360.
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© 1992 Springer Science+Business Media New York
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Berd, D. (1992). Inducing Immunity to Human Melanoma Cells: Opening the Bag of Immunological Tricks. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_22
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DOI: https://doi.org/10.1007/978-1-4615-3340-5_22
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4615-3340-5
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