Thymosin: An Innovative Approach to the Treatment of Chronic Hepatitis B

  • Milton G. Mutchnick
  • Glen D. Cummings
  • Jay H. Hoofnagle
  • David A. Shafritz


Chronic hepatitis B virus infection is a common disease afflicting 300 million people worldwide, including approximately one million Americans who are carriers of the hepatitis B surface antigen (HBSAg). Many such carriers have concomitant chronic liver disease and are at risk for developing cirrhosis, liver failure and hepatocellular carcinoma (1, 2). Impaired effectiveness of the host cellular immune mechanisms in clearing hepatitis B virus (HBV) infected hepatocytes has been proposed to explain development of chronic HBV infection (3, 4).


Hepatitis Delta Virus Peripheral Blood Mononuclear Thymic Hormone Chronic Woodchuck Hepatitis Virus Woodchuck Hepatitis Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Milton G. Mutchnick
    • 1
  • Glen D. Cummings
    • 1
  • Jay H. Hoofnagle
    • 2
  • David A. Shafritz
    • 3
  1. 1.Department of MedicineWayne State University School of MedicineDetroitUSA
  2. 2.Liver Disease Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.Liver Research CenterAlbert Einstein College of MedicineNew YorkUSA

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