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Ethanol and Lipid Disorders, Including Fatty Liver, Hyperlipemia, and Atherosclerosis

  • Charles S. Lieber

Abstract

Ethanol interference with lipid metabolism may lead not only to the well-known deposition of neutral lipids in the liver (Fig. 4.1)and some other tissues but also to functional disturbances because of changes in the lipid environment of cellular membranes. Ethanol-induced lipid changes have been implicated in the pathogenesis of diseases such as pancreatitis, hemolytic anemia, cardiomyopathy, and atherosclerosis.

Keywords

Fatty Liver Cholesteryl Ester Chronic Ethanol Fatty Acid Ethyl Ester Ethanol Administration 
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References

  1. Abrams, M. C., and Cooper, C.: Mechanism of increased hepatic uptake of unesterified fatty acid from serum of ethanol-treated rats. Biochem. J. 156:47–54, 1976.Google Scholar
  2. Adams, L. L., Webb, W. W, and Fallon, H. J.: Inhibition of hepatic triglyceride formation by clofibrate. J. Clin. Invest. 50:2339–2346, 1971.Google Scholar
  3. Albrink, M. J., and Klatskin, G.: Lactescence of serum following episodes of acute alcoholism and its probable relationship to acute pancreatitis. Am. J. Med. 23:26–33, 1957.Google Scholar
  4. Alcindor, L. G., Infante, R., Soler-Argilaga, C., Raisonnier, A., Polonovski, J., and Caroli, J.: Induction of the hepatic synthesis of 13-lipoproteins by high concentrations of fatty acids: Effect of actinomycin D. Biochim. Biophys. Acta. 210:483–486, 1970.Google Scholar
  5. Ailing, C., Aspenstom, G., Dencker, S. J., and Svennerholm, L.: Essential fatty acids in chronic alcoholism. Acta Med. Scand. Suppl. 631:1–38, 1979.Google Scholar
  6. Ailing, C., Gustaysson, L., and Änggärd, E.: An abnormal phospholipid in rat organs after ethanol treatment. FEBS Lett. 152:24–28, 1983.Google Scholar
  7. Ammon, H. P. T., and Zeller, W: Der Einfluss von α-Pyridylcarbinol auf die durch Alcohol erzeugte Fettleber der Ratte. Arzneim. Forsch. 15:1369–1371, 1965.Google Scholar
  8. Arai, M., Gordon, E. R., and Lieber, C. S.: Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim. Biophys. Acta 797:320–327, 1984a.Google Scholar
  9. Arai, M., Leo, M. A., Nakano, M., Gordon, E. R., and Lieber, C. S.: Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption. Hepatology 4:165–174, 1984b.Google Scholar
  10. Arai, M., Okuno, F., Nagata, S., Shigeta, Y., Takagi, S., Ebihara, Y., Kobayashi, T., Ishii, H., and Tsuchiya, M.: Platelet dysfunction and alteration of prostaglandin metabolism after chronic alcohol consumption. Scand J. Gastroenterol. 21: 1091 (abs), 1986.Google Scholar
  11. Arakawa, M., Taketomi, S., Furuno, K., Matsuo, T., Iwatsuka, H., and Suzuoki, Z.: Metabolic studies on the development of ethanol-induced fatty liver in KK-Ay mice.J. Nutr. 105: 1500–1508,1975.Google Scholar
  12. Ashley, M. J.: Alcohol consumption, ischemic heart disease, and cerebrovascular disease: An epidemiological perspective. J. Stud. Alcohol 43:869–887, 1982.Google Scholar
  13. Ashworth, C. T., Wrightsman, F., and Buttram, V.: Hepatic lipids. Arch. Pathol. 72:620–624, 1961.Google Scholar
  14. Avgerinos, A., Chu, P, Greenfield, C., Harry, D. S., and McIntyre, N.: Plasma lipid and lipoprotein response to fat feeding in alcoholic liver disease. Hepatology 3:349–355, 1983.Google Scholar
  15. Avogaro, P., and Cazzolato, G: Changes in the composition and physico-chemical characteristics of serum lipoproteins during ethanol-induced lipemia in alcoholic subjects. Metabolism 24:1231–1242, 1975.Google Scholar
  16. Avogaro, P., Cazzolato, G., Bittolo Bon, G., and Quinci, G. B.: Are apolipoproteins better discriminators than lipids for atherosclerosis? Lancet 1:901–903, 1979.Google Scholar
  17. Baker, H., Luisada-Opper, A., Sorrell, M. F., Thomson, A. D., and Frank, O.: Inhibition by nicotinic acid of hepatic steatosis and alcohol dehydrogenase in ethanol-treated rats. Exp. Mol. Pathol. 19:106–112, 1973.Google Scholar
  18. Balint, J. A.: The Liver: Annual 1/1981 (I. M. Arias, M. Frenkel, and J. H. P. Wilson, eds.), Amsterdam, Excerpta Medica, pp. 31–48, 1981.Google Scholar
  19. Ballantyne, F. C., Clark, R. S., Simpson, H. S., and Ballantyne, D.: High density and low density lipoprotein subfractions in survivors of myocardial infarction and in control subjects. Metabolism 31:433–437, 1982.Google Scholar
  20. Baraona, E., and Lieber, C. S.: Fatty liver, hyperlipemia and erythrocyte alterations produced by ethanol feeding in the rat. Am. J. Clin. Nutr. 22:356–357, 1969.Google Scholar
  21. Baraona, E., and Lieber, C. S.: Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat. J. Clin. Invest. 49:769–778, 1970.Google Scholar
  22. Baraona, E., and Lieber, C. S.: Effects of alcohol on hepatic transport of proteins. Annu. Rev. Med. 33:281–292, 1982.Google Scholar
  23. Baraona, E., Pirola, R. C., and Lieber, C. S.: The pathogenesis of postprandial hyperlipemia in rats fed ethanol-containing diets. J. Clin. Invest. 52:296–303, 1973.Google Scholar
  24. Baraona, E., Leo, M. A., Borowiky, S. A., and Lieber, C. S.: Pathogenesis of alcohol-induced accumulation of protein in the liver. J. Clin. Invest. 60:546–554, 1977.Google Scholar
  25. Baraona, E., Jauhonen, P, Miyakawa, H. and Lieber, C. S.: Zonal redox changes as a cause of selective perivenular hepatotoxicity of alcohol. Pharmacol. Biochem. Behay. 18:(suppl. 1)449–454, 1983a.Google Scholar
  26. Baraona, E., Savolainen, M., Karsenty, C., Leo, M. A., and Lieber, C. S.: Pathogenesis of alcoholic hypertriglyceridemia and hypercholesterolemia. Trans. Assoc. Am. Physicians 96: 306–315, 1983b.Google Scholar
  27. Barboriak, J. J.: Effect of ethanol on lipoprotein lipase activity. Life Sci. 5:237–241, 1966.Google Scholar
  28. Barboriak, J. J.: Alcohol, lipids and heart disease. Alcohol 1:341–345,1984.Google Scholar
  29. Barboriak, J. J., and Hogan, W. J.: Preprandial drinking and plasma lipids in man. Atherosclerosis 4:323–325, 1976.Google Scholar
  30. Barboriak, J. J., and Meade, R. C.: Enhancement of alimentary lipemia by preprandial alcohol. Am. J. Med. Sci. 255:245251, 1968.Google Scholar
  31. Barboriak, J. J., Anderson, A. J., Rimm, A. A., and Tristani, F. E.: Alcohol and coronary arteries. Alcoholism: Clin. Exp. Res. 3:29–32, 1979a.Google Scholar
  32. Barboriak, J. J., Anderson, A. J., and Hoffmann, R. G.: Interrelationship between coronary artery occlusion, high-density lipoprotein cholesterol, and alcohol intake. J. Lab. Clin. Med. 94:348–353, 1979b.Google Scholar
  33. Barboriak, J. J., Jacobson, G.R., Cushman, P., Herrington, R. E., Lipo, R. F, Daley, M. E., and Anderson, A. J.: Chronic alcohol abuse and high density lipoprotein cholesterol. Alcoholism: Clin. Exp. Res. 4:346–349, 1980.Google Scholar
  34. Barnett, A. H., Spiliopoulus, A. J., and Pyke, D. A.: Blockade of chlorpropamide-alcohol flush by indomethacin suggests an association. between prostaglandins and diabetic vascular complications. Lancet 2:164–166, 1980.Google Scholar
  35. Barrett-Connor, E., and Sharez, L.: A community study of alcohol and other factors associated with the distribution of high density lipoprotein cholesterol in older vs younger men. Am. J. Epidemiol. 115:888–893, 1982.Google Scholar
  36. Beaugé, F., Stibler, H., and Borg, S.: Abnormal fluidity and surface carbohydrate content of the erythrocyte membrane in alcoholic patients. Alcoholism: Clin. Exp. Res. 9:322–326, 1985.Google Scholar
  37. Beitz, J., Block, H.-U., Beitz, A., Muller, G., Winkler, L., Dargel, R., and Mest, H. J.: Endogenous lipoproteins modify the thromboxane formation capacity of platelets. Atherosclerosis 60:95–99, 1986.Google Scholar
  38. Betfrage, P., Berg, B., Cronholm, T., Elmqvist, D., Hägerstrand, I., Johansson, B., Nilsson-Ehle, P., Nordèn, G., Sjövall, J., and Wiebe, T: Prolonged administration of ethanol to young, healthy volunteers: Effects on biochemical, morphological and neurophysiological parameters. Acta Med. Sand. Suppl. 552:1–44, 1973.Google Scholar
  39. Belfrange, P., Berg, B., Hägerstrand, I., Nilsson-Ehle, P., Tornquist, H., and Wiebe, T.: Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake. Eur. J. Clin. Invest. 7:127–131, 1977.Google Scholar
  40. Berg, T., and Mørland, J.: Effects of chronic ethanol treatment on rat liver lysosomes. Acta Pharmacol. Toxicol. 33:409–416, 1973.Google Scholar
  41. Best, C. H., Hartroft, W. S., Lucas, C. S., and Ridout, J. H.: Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br. Med. J. I I:1001–1006, 1949.Google Scholar
  42. Bezman-Tarcher, A., Nestel, P. J., Felts, J. M., and Havel, R. J.: Metabolism of hepatic and plasma triglycerides in rabbits given ethanol or ethionine. J. Lipid Res. 2:248–257, 1966.Google Scholar
  43. Bizzi, A., Tacconi, M. T., Veneroni, E., and Garattini, S.: Tri-glyceride accumulation in liver. Nature 209:1025–1026, 1966.Google Scholar
  44. Blackwelder, W. C., Yano, K., Rhoads, G. G., Kagan, A., Gordon, T., and Palesch, Y.: Alcohol and mortality: The Honolulu heart study. Am. J. Ivied. 68:164–169, 1980.Google Scholar
  45. Blomstrand, R., and Forsell, L.: Prevention of the acute ethanol-induced fatty liver by 4-methylpyrazole. Life Sci. 10(Part I I): 523–530, 1971.Google Scholar
  46. Blomstrand, R., and Kager, L.: The combustion of triolein-1-14C and its inhibition by alcohol in man. Life Sci. 13:113–123, 1973.Google Scholar
  47. Blomstrand, R., Kager, L., and Lantto, O.: Status of studies on the ethanol-induced decrease of fatty acid oxidation in rat and human liver slices. Life Sci. 13:1131–1141, 1973.Google Scholar
  48. Bloomfield, A. L., and Shenson, B.: The syndrome of idiopathic hyperlipemia with crises of violent abdominal pain. Stanford Med. Bull. 5:185–191, 1947.Google Scholar
  49. Borowsky, S. A., Perlow, W, Baraona, E., and Lieber, C. S.: Relationship of alcoholic hypertriglyceridemia to stage of liver disease and dietary lipid. Dig. Dis. Sci. 25:22–27, 1980.Google Scholar
  50. Böttiger, L. E., Carlson, L. A., Hultman, E. M., and Romanus, V.: Serum lipids in alcoholics. Acta Med. Scand. 199:357–361, 1976.Google Scholar
  51. Boyer, J. L.: Effect of chronic ethanol feeding on bile formation and secretion of lipids in the rat. Gastroenterology 62:294301, 1972.Google Scholar
  52. Breier, C., Lisch, H.-J., Drexel, H., and Braunsteiner, H.: Post-heparin lipolytic activities and alterations of the chemical composition of high density lipoproteins in alcohol-induced type V hyperlipidemia. Atherosclerosis 52:317–328, 1984.Google Scholar
  53. Brewster, A. C., Lankford, H. G., Schwartz, M. G., and Sullivan, J. F.: Ethanol and alimentary lipemia. Am. J. Clin. Nutr. 19:255–259, 1966.Google Scholar
  54. Brodie, B. B., Butler, W. M., Horning, M. G., Maickel, R. P, and Mating, H. M.: Alcohol-induced triglyceride deposition in liver through derangement of fat transport. Am. J. Clin. Nutr. 9:432–435, 1961.Google Scholar
  55. Brown, D. F.: The effect of ethyl α-p-chlorophenoxyisobutyrate on ethanol-induced hepatic steatosis in the rat. Metabolism 15: 868–873,1966.Google Scholar
  56. Brunengraber, H., Boutry, M., Lowenstein, L., and Lowenstein, J. M.: The effect of ethanol on lipogenesis by the perfused liver. in: Alcohol and Aldehyde Metabolizing Systems (R. G. Thurman, T. Yonetani, J. R. Williamson, and B. Chance, eds.), New York, Academic Press, pp. 329–337, 1974.Google Scholar
  57. Brunzell, J. D., and Bierman, E. L.: Chylomicronemia syndrome: Interaction of genetic and acquired hypertriglyceridemia. Med. Clin. North Am. 66:455–468, 1982.Google Scholar
  58. Bustos, G. O., Kalant H., Khanna, J. M., and Loth, J.: Pyrazole and induction of fatty liver by a single dose of ethanol. Science 168:1598–1599, 1970.Google Scholar
  59. Cachera, R., Lamotte, M., and Lamotte-Barrillon, S.: Etude clinique, biologique et histologique des stéatoses du foie chez les alcooliques. Sem. Hop. 26:3497–3514, 1950.Google Scholar
  60. Camargo, C. A., Williams, P T, Vranizan, K. M., Albers, J. J., and Wood, P D.: The effect of moderate alcohol intake on serum apoliproteins A-I and A-II. J.A.M.A. 253:2854–2857, 1985.Google Scholar
  61. Cameron, J. L., Capuzzi, D. M., Zuidema, G. D., and Margolis, S.: Acute pancreatitis with hyperlipemia: Evidence for a persistent defect in lipid metabolism. Am. J. Med. 56:482–487,1974.Google Scholar
  62. Castelli, W. P, Gordon, T., Hjortland, M. C., Kagan, A., Doyle, J. T., Hames, C. G., Hulley, S. B., and Zukel, W. J.: Alcohol and blood lipids. Lancet 2:153–155, 1977.Google Scholar
  63. Cederbaum, A. L., Lieber, C. S., Beattie, D. S., and Rubin, E.: Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria. J. Biol. Chem. 250:5122–5129, 1975.Google Scholar
  64. Chait, A., February, A. E., Mancini, M., and Lewis, B. L.: Clinical and metabolic study of alcoholic hyperlipidemia. Lancet 2:62–64, 1972.Google Scholar
  65. Chalvardjian, A.: Mode of action of choline. V. Sequential changes in hepatic and serum lipids of choline-deficient rats. Can. J. Biochem. 48:1234–1240, 1970.Google Scholar
  66. Chance, B., Sies, H., and Boveris, A.: Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59:527–605, 1979.Google Scholar
  67. Chin, J. H., and Goldstein, D. B.: Effects of low concentration of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. Mol. Pharmacol. 13:435–441, 1977.Google Scholar
  68. Chin, J. H., Parson, L. M., and Goldstein, D. R.: Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice. Biochim. Biophys. Acta. 513:358–363,1978.Google Scholar
  69. Cohen, B. I., and Raicht, R. E: Sterol metabolism in the rat: Effect of alcohol on sterol metabolism in two strains of rats. Alcoholism: Clin. Exp. Res. 5:225–229, 1981.Google Scholar
  70. Corredor, C., Mansbach, C., and Bressler, R.: Choline control of tissue carnitine content. Fed. Proc. 26:278, 1967.Google Scholar
  71. Crouse, J. R., Gerson, C. D., DeCarli, L. M., and Lieber, C. S.: Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man. J. Lipid Res. 9:509–512, 1968.Google Scholar
  72. Cunningham, C. C., Filus, S., Bottenus, R. E., and Spach, P. I.: Effect of ethanol consumption on the phospholipid composition of rat liver microsomes and mitochondria. Biochim. Biophys. Acta 712:225–233, 1982.Google Scholar
  73. Cunningham, C. C., Bottenus, R. E., Spach, P. I., and Rudel, L. L.: Ethanol-related changes in liver microsomes and mitochondria from the monkey, Macaca fascicularis. Alcoholism: Clin. Exp. Res. 7:424–430, 1983.Google Scholar
  74. Cushman, P., Barboriak, J. J., Liao, A., and Hoffman, N. E.: Association between plasma high density lipoprotein cholesterol and antipyrine metabolism in alcoholics. Life Sci. 30:1721–1724,1982.Google Scholar
  75. Cuvelier, I., Steinmetz, J., Mikstacki, T., and Siest, G.: Variations in total phospholipids and high-density lipoprotein phospholipids in plasma from a general population: Reference intervals and influence of xenobiotics. Clin. Chemist. 31:763–766,1985.Google Scholar
  76. Danielsson, B., Ekman, R., Fex, G., Johansson, B. G., Kristensson, H., Nilsson-Ehle, P., and Wadstein, J.: Changes in plasma high density lipoproteins in chronic male alcoholics during and after abuse. Scand. J. Clin. Lab. Invest. 38:113–119, 1978.Google Scholar
  77. Dawidowicz, E. A.: The effect of ethanol on membranes. Hepatology 5:697–699, 1985.Google Scholar
  78. Day, R. C., Harry, D. S., Owen, J. S., Foo, A. Y., and McIntyre, N.: Lecithin-cholesterol acyltransferase and the lipoprotein abnormalities of parenchymal liver disease. Clin. Sci. 56:575–583,1979.Google Scholar
  79. Debry, G., Mejean, L., Max, J. P., Lambert, D., Pointel, J.-P., and Drouin, P: Effects of alcohol intake on several metabolic parameters in primary hyperlipoproteinemia. In: Metabolic Effects of Alcohol (P Avogaro, C. R. Sirtori, and F. Tremoli, eds.), Amsterdam, The Netherlands, Elsevier/North Holland Biomedical Press, pp. 227–234, 1979.Google Scholar
  80. DeCarli, L. M., and Lieber, C. S.: Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J. Nutr. 91:331–336, 1967.Google Scholar
  81. Declercq, P. E., Debeer, L. J., and Mannaerts, G. P: Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate content. Biochem. J. 202:803–806, 1982.Google Scholar
  82. DeGennes, J. L., Thomopoulus, P, Truffert, J., and Labrousse de Tregomain, B.: Hyperlipemies dépendantes de l’alcool. Nutr Metab. 14:141–158, 1972.Google Scholar
  83. Devenyi, P, Robinson, G. M., and Roncari, D. A. K.: Alcohol and high-density lipoproteins. Can. Med. Assoc. J. 123:981–984, 1980.Google Scholar
  84. Dich, J., Bro, B., Grunnet, N., Jensen, E, and Kondrup, J.: Accumulation of traicylglycerol in cultured rat hepatocytes is increased by ethanol and by insulin and dexamethasone. Biochem. J. 212:617–623, 1983.Google Scholar
  85. Di Luzio, N. R.: Effect of acute ethanol intoxication on liver and plasma lipid fractions of the rat. Am. J. Physiol. 194:453–456,1958.Google Scholar
  86. Di Luzio, N. R.: A mechanism of the acute ethanol-induced fatty liver and the modification of liver injury by antioxidant. Lab. Invest. 15:50–63, 1966.Google Scholar
  87. Domanski, R., Rifenberick, D., Stearns, F., Scorpio, R. M., Narrod, S. A., and Narrod, M. F: Ethanol-induced fatty liver in rats: Effects of pyrazole and glucose. Proc. Soc. Exp. Biol. Med. 138:18–20, 1971.Google Scholar
  88. Ducceschi, V.: La colesterina del sangue nella intossieazione per alcool. Arch. Fisiol. 13:147–153, 1915.Google Scholar
  89. Duhamel, G., Nalpas, B. Goldstein, S., Lapland, P M., Berthelot, P., and Chapman, M. J.: Plasma lipoprotein and apolipoprotein profile in alcoholic patients with and without liver disease: On the relative roles of alcohol and liver injury. Hepatology 4:577–585, 1984.Google Scholar
  90. Dyer, A. R., Stamler, J., Paul, O., Berkson, D. M., Shekelle, R. B., Lepper, M. H., McKean, H., Lindberg, H. A., Garside, D., and Tokich, T.: Alcohol, cardiovascular risk factors, and mortality: The Chicago experience. Circulation 64(Suppl III):20–27, 1981.Google Scholar
  91. Eberhardt, G., Mo’hr, J., Oehlert, W., Schmidt, E., Schmidt, E W., and Vondrasek, P.: Kohtrollierte Studie zur therapeutischen Wirkung von B-Vitaminen und einem anabolen Steroid bei chronischer Hepatitis. Dtsch. Med. Wochenschr. 100:2074–2082, 1975.Google Scholar
  92. Edreira, J. G., Hirsch, R. L., and Kennedy, J. A.: Production of fatty liver with dietary ethanol despite orotic acid supplementation. Q. J. Stud. Alcohol 35:20–25, 1974.Google Scholar
  93. Eichner, E. R.: Alcohol versus exercise for coronary protection. Am. J. Med. 79:231–240, 1985.Google Scholar
  94. Ekman, R., Fex, G., Johansson, B. G., Nilsson-Ehle, P, and Wadstein, J.: Changes in plasma high density lipoproteins and lipolytic enzymes after long-term, heavy consumption. Scand. J. Clin. Lab. Invest. 41:709–715, 1981.Google Scholar
  95. Elko, E. E., Wooles, W. R., and Di Luzio, N. R.: Alterations and mobilization of lipids in acute ethanol-treated rats. Am. J. Physiol. 201:923–926, 1961.Google Scholar
  96. Ernest, N., Fisher, M., Smith, W, Gordon, T, Rifkind, B. M., Little, J. A., Mishkel, M. A., and Williams, O. D.: The association of plasma high-density lipoprotein cholesterol with dietary intake and alcohol consumption: The Lipid Research Clinics Prevalence study. Circulation 62(Suppl. IV): 41–52,1980.Google Scholar
  97. Estler, C. J., and Ammon, H. P. T: The influence of beta adrenergic blockade on the ethanol-induced derangement of lipid transport. Arch. Int. Pharmacodyn. Titer. 166:333–341, 1967.Google Scholar
  98. Fallat, R. W, Vester, J. W., and Glueck, C. J.: Suppression of amylase activity by hypertriglyceridemia. J.A.M.A. 225: 1331–1334,1973.Google Scholar
  99. Fallon, H. J., Lamb, R. G., and Jamdar, S. C.: Phosphatidate phosphohydrolase and the regulation of glycerolipid biosynthesis. Biochem. Soc. Trans. 5:37–40, 1977.Google Scholar
  100. Farmer, R. G., Winkelman, E. I., Brown, H. B., and Lewis, L. A.: Hyperlipoproteinemia and pancreatitis. Am. J. Med. 54:161–165, 1973.Google Scholar
  101. Feigl, J.: Neue Untersuchungen zur Chemte des Mutes bei akuter Alkcohol Intoxikation und bei chronischem Alkoholismus mit ‘besonderer Berucksichtigung der Fette und Lipoide. Biochem. Z. 92:282–317, 1918.Google Scholar
  102. Feinman, L., and Lieber, C. S.: Effect of ethanol on plasma glycerol in man. Am. J. Clin. Nutr. 20:400–403, 1967.Google Scholar
  103. Fellenius, E., Bengtsson, G., and Kiessling, K.-H.: The influence of ethanol-induced changes of the a-glycerophosphate level on hepatic triglyceride synthesis. Acta Chem. Scand. 27: 2893–2901,1973.Google Scholar
  104. Fenster, L. F: The non-efficacy of short-term anabolic steroid therapy in alcoholic liver disease. Ann. Intern. Med. 65:738–744,1966.Google Scholar
  105. Field, F. J., Boydstun, J. S., and LaBrecque, D. R.: Effect of chronic ethanol ingestion on hepatic and intestinal acyl coenzyme A: Cholesterol acyltransferase and 3-hydroxy-3methylglutaryl coenzyme A reductase in the rat. Hepatology 5:133–138, 1985.Google Scholar
  106. Flores, H., Pak, N., Maccioni, A., and Monckeberg, F: Lipid transport in kwashiorkor. Br. J. Mar. 24:1005–1011, 1970.Google Scholar
  107. Forsander, O. A., Mäenpää, P. H., and Salaspuro, M. P.: Influence of ethanol on the lactate/pyruvate and ß-hydroxybutyrate/ acetoacetate ratios in rat liver experiments. Acta Chem. Scand. 19:1770–1771, 1965.Google Scholar
  108. Förstermann, U., and Feuerstein, T. J.: Decreased systemic formation of prostaglandin E and prostacyclin, and unchanged thromboxane formation, in alcoholics during withdrawal as estimated from metabolites in urine. Clin. Sci. 73:277–283, 1987.Google Scholar
  109. Fraser, G. E., and Upsdell, M.: Alcohol and other discriminants between cases of sudden death and myocardial infarction. Am. J. Epidemiol. 114:462–476, 1981.Google Scholar
  110. Fraser, G. E., Anderson, J. T.; Foster, W, Goldberg, R., Jacobs, D., and Blackburn, H.: The effect of alcohol on serum high density lipoprotein (HDL). Atherosclerosis 46:275–286, 1983.Google Scholar
  111. Freeman, M., Kuiken, L., Ragland, J. B., and Sabesin, S. M.: Hepatic triglyceride lipase deficiency in liver disease. Lipids 12:443–445, 1977.Google Scholar
  112. Friedman, H. S.: Cardiovascular effects of alcohol with particular reference to the heart. Alcohol 1:333–339, 1984.Google Scholar
  113. Friedman, M., Rosenman, R. H., and Byers, S. O.: Effect of moderate ingestion of alcohol upon serum triglyceride responses of normo-and hyperlipemic subjects. Proc. Soc. Exp. Biol. Med. 120:696–698, 1965.Google Scholar
  114. Ginsberg, H., Olefsky, J., Farquhar, J. W, and Reaven, G. M.: Moderate ethanol ingestion and plasma triglyceride levels. Ann. Intern. Med. 80:143–149, 1974.Google Scholar
  115. Glenny, H. P, and Brindley, D. N.: The effect of cortisol, corticotropin and thyroxine on the synthesis of glycerolipids and on the phosphatidate phosphohydrolase activity in rat liver. Biochem. J. 176:777–784, 1978.Google Scholar
  116. Glueck, C. J., Hogg, E., Allen, C., and Gartside, P. S.: Effects of alcohol ingestion on lipids and lipoproteins in normal men: Isocaloric metabolic studies. Am. J. Clin. Nutr. 33:2287–2293, 1980.Google Scholar
  117. Glueck, C. J., Heiss, G., Morrison, J. A., Khoury, P., and Moore, M.: Alcohol intake, cigarette smoking and plasma lipids and lipoproteins in 12–19-year-old children. Circulation 64: (Suppl. III):48–56, 1981.Google Scholar
  118. Goebel, K. M., Goebel, F D., Schubotz, R., and Schneider, J.: Hemolytic implications of alcoholism in liver disease. J. Lab. Clin. Med. 94:123–132, 1979.Google Scholar
  119. Gofman, J. W, Young, W, and Tandy, R.: Ischemic heart disease, atherosclerosis, and longevity. Circulation 34:679–697, 1966.Google Scholar
  120. Goldberg, C. S., Tall, A. R., and Krumholz, S.: Acuté inhibition of hepatic lipase and increase in plasma lipoproteins after alcohol intake. J. Lipid Res. 25:714–720, 1984.Google Scholar
  121. Goodman, D. S., and Deykin, D.: Fatty acid ethyl ester formation during ethanol metabolism in vivo. Proc. Soc. Exp. Biol. Med. 113:65–67, 1963.Google Scholar
  122. Gordon, E. R.: Effect of an intoxicating dose of ethanol on lipid metabolism in an isolated pet-fused rat liver. Biochem. Pharmacol. 21:2991–3004, 1972.Google Scholar
  123. Gordon, E. R.: Mitochondrial functions in an ethanol-induced fatty liver. J. Biol. Chem. 248:8271–8280, 1973.Google Scholar
  124. Gordon, E. R., Rockiman, J., Arai, M., and Lieber, C. S.: Lack of correlation between hepatic mitochondrial membrane structure and functions in ethanol-fed rats. Science 216:1319–1321, 1982.Google Scholar
  125. Gordon, T., and Doyle, J. T.: Drinking and coronary heart disease: The Albany study. Am. Heart J. 110:331–334, 1985.Google Scholar
  126. Green, F. A., and Claesson, H.-E.: Ethanol-enhanced trans-membrane penetration of arachidonic acid and activation of the 5-lipooxygenase pathway in human leukocytes. Biochem. Biophys. Res. Commun. 140:782–788, 1986.Google Scholar
  127. Greenberger, N. J., Hatch, F T., Drummey, G. D., and Isselbacher, K. J.: Pancreatitis and hyperlipemia: A study of serum lipid alterations in 25 patients with acute pancreatitis. Medicine (Baltimore) 45:161–174, 1966.Google Scholar
  128. Grossberg, S. J.: Lipemia retinalis, hyperlipemia, and hepatosplenomegaly in chronic alcoholic patient. N.Y. State J. Med. 66:2951–2953, 1966.Google Scholar
  129. Guivernau, M., Baraona, E., and Lieber, C. S.: Acute and chronic effects of ethanol and its metabolites on vascular production of prostacyclin in rats. J. Pharmacol. Exp. Ther. 240:59–64, 1987.Google Scholar
  130. Guivemau, M., Baraona, E., Soong, J., and Lieber, C. S.: Enhanced stimulatory effect of HDL and other agonists on vascular prostacyclin production in rats fed alcohol-containing diets. Biochem. Pharmacol. 38:503–508, 1989.Google Scholar
  131. Guynn, R. W, Veloso, D., Harris, R. L., Lawson, J. W. R., and Veech, R. L.: Ethanol administration and the relationship of malonyl-coenzyme A concentrations to the rate of fatty acid synthesis in rat liver. Biochem. J. 136:639–647, 1973.Google Scholar
  132. Guzman, M., and Geelen, M. J. H.: Effects of ethanol feeding on the activity and regulation of hepatic camitine palmitoyltransferase. Arch. Biochem. Biophys. 267:580–588, 1988.Google Scholar
  133. Haffner, S. M., Applebaum-Bowden, D., Wahl, P W, Hoover, J. J., Warnick, G. R., Albers, J. J., and Hazzard, W. R.: Epidemiological correlates of high density lipoprotein sub-fractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase: Effects of smoking, alcohol, and adiposity. Arteriosclerosis 5:169–177, 1985.Google Scholar
  134. Haines, D. S. M.: The effects of choline deficiency and choline re-feeding upon the metabolism of plasma and liver lipids. Can. J. Biochem. 44:45–57, 1966.Google Scholar
  135. Hajjar, D. P: Prostaglandins and cyclic nucleotides: Modulators of arterial cholesterol metabolism. Biochem. Pharmacol. 34: 295–300, 1985.Google Scholar
  136. Harada, S., Agarwal, D. P, Goedde, H. W., and Ishikawa, B.: Aldehyde dehydrogenase isoenzyme variation and alcoholism in Japan. Pharmacol. Biochem. Behay. 18:151–153, 1983.Google Scholar
  137. Hartman, A. D., and Di Luzio, N. R.: Inhibition of the chronic ethanol-induced fatty liver by antioxidant administration. Proc. Soc. Exp. Biol. Med. 127:270–281, 1968.Google Scholar
  138. Hartung, G. H., Foreyt, J. P, Mitchell, R. E., Mitchell, J. G., Reeves, R. S., and Gotto, A. M., Jr.: Effect of alcohol intake on high-density lipoprotein cholesterol levels in runners and inactive men. JA.M.A. 249:747–750, 1983.Google Scholar
  139. Haskell, W. L., Camargo, C., Jr., Williams, P. T., Vranizan, K. M., Krauss, R. M., Lindgren, F. T, and Wood, P D.: The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions: A controlled study. N. Engl. J. Med. 310:805–810, 1984.Google Scholar
  140. Hasumura, Y., Teschke, R., and Lieber, C. S.: Characteristics of acetaldehyde oxidation in rat liver mitochondria. J. Biol. Chem. 251:4908–4913, 1976.Google Scholar
  141. Hegsted, M. D., and Ausman, L. M.: Diet, alcohol, and coronary heart disease in men. J. Nutr. 118:1184–1189, 1988.Google Scholar
  142. Hennekens, C. H., Rosner, B., and Cole, D. S.: Daily alcohol consumption and fatal coronary heart disease. Am. J. Epidemiol. 107:196–200, 1978.Google Scholar
  143. Hernandez-Munoz, R., Santamaria, A., Garcia-Sainz, J. A., Pina, E., and Chagoya-de-Sanchez, V: On the mechanism of ethanol-induced fatty liver and its reversibility by adenosine. Arch. Biochem. Biophys. 190:155–162, 1978.Google Scholar
  144. Hillborn, M., Kangasaho, M., Lowbeer, C., Kaste, M., Muuronen, A., and Numminen, H.: Effects of ethanol on platelet function. Alcohol 2:429–432, 1985.Google Scholar
  145. Hoffbauer, F. W, and Zaki, F. G.: Choline deficiency in baboon and rat compared. Arch. Pathol. 79:364–369, 1965.Google Scholar
  146. Holman, R. T., and Johnson, S.: Changes in essential fatty acid profile of serum phospholipids in human disease. Prog. Lipid Res. 20:67–73, 1981.Google Scholar
  147. Holmström, B.: Studies on the metabolism of 14C-labeled ethanol in man. V. Synthesis of liver fatty acids. Ark. Kemi 30:333–345,1969.Google Scholar
  148. Horning, M. B., Williams, E. A., Maling, H. M., and Brodie, B. B.: Depot fat as source of increased liver triglycerides after ethanol. Biochem. Biophys. Res. Commun. 3:635–640, 1960.Google Scholar
  149. Hulley, S. B., and Gordon, S.: Alcohol and high-density lipoprotein cholesterol: Causal inference from diverse study designs. Circulation 64(Suppl 3):57–63, 1981.Google Scholar
  150. Hymns, D. E., and Isselbacher, K. J.. Prevention of fatty liver by administration of adenosine triphosphate. Nature 204:1196–1197, 1964.Google Scholar
  151. Ide, H., and Nakazawa, Y.: Role of acetaldehyde in ethanol-induced increase in the activity of phosphatidate phosphatase in rat liver. Biochem. Pharmacol. 36:2443–2448, 1987.Google Scholar
  152. Ideo, G., Bellobuono, A., and Bellati, G.: Bilirubin excretion in bile decreased by large amounts of ethanol in isolated and perfused rat liver. Biomedicine 29:225–227, 1978.Google Scholar
  153. Iseri, O. A., Lieber, C. S., and Gottlieb, L. S.: The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am. J. Pathol. 48:535–555, 1966.Google Scholar
  154. Jaillard, J., Dewailly, P, Sezille, G., Fruchart, J. C., Rault, C., and Scherpe-Reel, P: Intérêt et signification du test d’hyperlipemie par voie veineuse dans l’exploration des hyperlipemies: Étude de ses variations sous l’effet de l’alcool. Atherosclerosis 19:493–500, 1974.Google Scholar
  155. Janus, E. D., and Lewis, B.: Alcohol and abnormalities of lipid metabolism. Clin. Endocrinol. Metab. 7:321–332, 1978.Google Scholar
  156. Jauhonen, V. P., and Hassinen, I. E.: Metabolic and hormonal changes during intravenous infusion of ethanol, acetaldehyde and acetate in normal and adrenalectomized rats. Arch. Biochem. Biophys. 191:358–366, 1978.Google Scholar
  157. Jauhonen, V. P, Savolainen, M. J., and Hassinen, I. E.: Cyclic AMP-linked mechanisms in ethanol-induced derangements of metabolism in rat liver and adipose tissue. Biochem. Pharmacol. 24:1879–1883, 1975.Google Scholar
  158. Jauhonen, P, Baraona, E., Miyakawa, H., and Lieber, C. S.: Mechanism for selective perivenular hepatotoxicity of ethanol. Alcoholism: Clin. Exp. Res. 6:350–357, 1982.Google Scholar
  159. Jerntorp, P. Ohlin, H., Bergstrom, B., and Almer, L.: Increase of plasma acetaldehyde: An objective indicator of the chlorpropamide alcohol flush. Diabetes 30:788–791, 1981.Google Scholar
  160. Johansson, B. G., and Laurell, C. B.: Disorders of serum a-lipoproteins after alcoholic intoxication. Scand. J. Clin. Lab. Invest. 23:231–233, 1969.Google Scholar
  161. Johansson, B. C., and Medhus, A.: Increase in plasma a-lipoproteins in chronic alcoholics after acute abuse. Acta. Med. Scand. 195:273–277, 1974.Google Scholar
  162. John, G. R., Littleton, J. M., and Jones, P. A.: Membrane lipids and ethanol tolerance in the mouse: The influence of dietary fatty acid composition. Life Sci. 27:545–555, 1980.Google Scholar
  163. Johnson, O.: Influence of blood ethanol concentration on the acute ethanol-induced liver triglyceride accumulation in rats. Scand. J. Clin. Lab. Invest. 33:207–213, 1974.Google Scholar
  164. Johnson, D. A., Lee, N. M., Cooke, R., and Loh, H. H.: Ethanol-induced fluidization of main lipid bilayers required presence of cholesterol in membranes for the expression of tolerance. Mol. Pharmacol. 15:739–746, 1979.Google Scholar
  165. Johnson, O., Hernell, O., Fex, G., and Olivecrona, T.: Ethanol-induced fatty liver: The requirement of ethanol metabolism for the development of fatty liver. Life Sci. 10:553–559, 1971.Google Scholar
  166. Johnson, S. B., Gordon, E., McClain, C., Low, G., and Holman, R. T.: Abnormal polyunsaturated fatty acid patterns of serum lipids in alcoholism and cirrhosis: Arachidonic acid deficiency in cirrhosis. Proc. Natl. Acad. Sci. USA 82:1815–1818, 1985.Google Scholar
  167. Joly, J. G., Feinman, L., Ishii, H., and Lieber, C. S.: Effect of chronic ethanol feeding on hepatic microsomal glycerophosphate acyltransferase activity. J. Lipid Res. 14:337–343, 1973.Google Scholar
  168. Jones, A. L., Ruderman, N. B., and Herrera, M. G.: Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J. Lipid Res. 8:429–446, 1967.Google Scholar
  169. Jones, D. P, Losowsky, M. S., Davidson, C. S., and Lieber, C. S.: Effects of ethanol on plasma lipids in man. J. Lab. Clin. Med. 62:675–682, 1963.Google Scholar
  170. Jones, D. P., Perman, E. S., and Lieber, C. S.: Free fatty acid turnover and triglyceride metabolism after ethanol ingestion in man. J. Lab. Clin. Med. 66:804–813, 1965.Google Scholar
  171. Kaffarnik, H., and Schneider, J.: Short-term effect of ethyl alcohol on serum lipids of healthy fasting persons. Z. Gesamte Exp. Med. 152:187–200, 1970.Google Scholar
  172. Kähönen, M. T, Ylikahri, R. H., and Hassinen, I.: Studies on the mechanism of inhibition of acute alcoholic fatty liver by clofibrate. Metabolism 21:1021–1028, 1972.Google Scholar
  173. Kalant, H., Khanna, J. M., and Bustos, G. O.: Effect of pyrazole on the induction of fatty liver by chronic administration of ethanol. Biochem. Pharmacol. 21:811–819, 1972.Google Scholar
  174. Kangasaho, M., Hillbom, M., Kaste, M., and Vapaatalo, H.: Effects of ethanol intoxication and hangover on plasma levels of thromboxane B2 and 6-keto prostaglandin Flα and on thromboxane B2 formation by platelets in man.Throm. Haemostasis 49:232–234, 1982.Google Scholar
  175. Karsenty, C., Baraona, E., Savolainen, M. J., and Lieber, C. S.: Effects of chronic ethanol intake on mobilization and excretion of cholesterol in baboons. J. Clin. Invest. 75:976–986, 1985.Google Scholar
  176. Kessler, J. I., and Yalovsky-Mishkin, S.: Effect of ingestion of saline, glucose, and ethanol on mobilization and hepatic incorporation of epididymal pad palmitate-1-14C in rats. J. Lipid Res. 7:772–777, 1966.Google Scholar
  177. Kikuchi, T, and Kako, K. J.: Metabolic effects of ethanol on the rabbit heart. Circ. Res. 26:625–634, 1970.Google Scholar
  178. Kim, C. I., Leo, M. A., Lowe, N., and Lieber, C. S.: Effects of vitamin A and ethanol on liver plasma membrane fluidity. Hepatology 8:735–741, 1988.Google Scholar
  179. Kitson, T. M.: The disulfiram-ethanol reaction. J. Stud. Alcohol 38:96–113, 1977.Google Scholar
  180. Kittner, S. J., Garcia-Palmieri, M. R., Costas, R., Jr., Cruz-Vidal, M., Abbott, R. D. and Havlik, R. J.: Alcohol and coronary heart disease in Puerto Rico. Am. J. Epidemiol. 117:538–550, 1983.Google Scholar
  181. Klatskin, G., Krehl, W. A., and Conn, H. O.: The effect of alcohol on the choline requirement. I. Changes in the rat’s liver following prolonged ingestion of alcohol. J. Exp. Med. 100: 605–614, 1954.Google Scholar
  182. Klatsky, A. L., Friedman, G. D., and Siegelaub, A. B.: Alcohol consumption before myocardial infarction: Results from the Kaiser-Permanente epidemiologic study of myocardial infarction. Ann. Intern. Med. 81:294–301, 1974.Google Scholar
  183. Klatsky, A. L., Friedman, G. D., and Siegelaud, A. B.: Alcohol and mortality: A ten-year Kaiser-Permanente experience. Ann. Intern. Med. 95:139–145, 1981.Google Scholar
  184. Knochel, J. P.: Cardiovascular effects of alcohol. Ann. Intern. Med. 98 (Part 2):849–854, 1983.Google Scholar
  185. Koff, R. S., and Fitts, J. J.: Chlorpromazine inhibition of ethanol metabolism without prevention of fatty liver. Biochem. Med. 6:77–81, 1972.Google Scholar
  186. Kondrup, J., and Grunnet, N.: The effect of acute and prolonged ethanol treatment on the contents of coenzyme A, carnitine and their derivatives in rat liver. Biochem. J. 132:373–379, 1973.Google Scholar
  187. Kontula, K., Vilnikka, L., Ylikorkala, O., and Ylikahri, R.: Effect of acute ethanol intake on thromboxane and prostacyclin in human. Life Sci. 31:261–264, 1982.Google Scholar
  188. Kovatchev, S., and Eibl, H.: The preparation of phospholipids by phospholipase D. Adv. Exp. Med. Biol. 101:221–226, 1978.Google Scholar
  189. Kraus, R. M.: Regulation of high density lipoprotein levels. Med. Clin. North Am. 66:403–429, 1982.Google Scholar
  190. Kudzma, D. J., and Schonfeld, G.: Alcoholic hyperlipidemia: Induction by alcohol but not by carbohydrate. J. Lab. Clin. Med. 77:384–389, 1971.Google Scholar
  191. Lakshman, M. R., and Ezekiel, M.: Relationship of alcoholic hyperlipidemia to the feed-back regulation of hepatic cholesterol synthesis by chylomicron remnants. Alcoholism: Clin. Exp. Res. 6:482–486, 1982.Google Scholar
  192. Lakshman, M. R., and Veech, R. L.: Short-term and long-term effects of ethanol administration in vivo on rat liver HMGCoA reductase and cholesterol 7α-hydroxylase activities. J. Lipid Res. 18:325–330, 1977.Google Scholar
  193. Lakshman, M. R., Ezekiel, M., Campbell, B. S., and Muesing, R. A.: Binding, uptake, and metabolism of chylomicron remnants by hepatocytes from control and chronic ethanol-fed rats. Alcoholism: Clin. Exp. Res. 10:412–418, 1986.Google Scholar
  194. Lakshman, M. R., Chirtel, S. J., and Chambers, L. L.: Roles of ω3 fatty acids and chronic ethanol in the regulation of plasma and liver lipids and plasma apoproteins Al and E in rats. J. Nutr. 118:1299–1303, 1988.Google Scholar
  195. Lamb, R. G., Wood, C. K., and Fallon, H. J.: The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster. J. Clin. Invest. 63:14–20, 1979.Google Scholar
  196. Lange, L. G.: Nonoxidative ethanol metabolism: Formation of fatty acid et hyl esters by cholesterol esterase. Proc. Natl. Acad. Sci. USA 79:3954–3957, 1982.Google Scholar
  197. Lange, L. G., Bergmann, S. R., and Sobel, B. E.: Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. J. Biol. Chem. 256:12968–12973, 1981.Google Scholar
  198. Leathers, C. W, Bond, M. G., Bullock, B. C., and Rudel, L. L.: Dietary ethanol and cholesterol in Macaca nemestrina serum lipid and hepatic changes. Exp. Mol. Pathol. 35:285–299, 1981.Google Scholar
  199. Lefevre, A. F., DeCarli, L. M., and Lieber, C. S.: Effect of ethanol on cholesterol and bile acid metabolism. J. Lipid Res. 13:4855, 1972.Google Scholar
  200. Lehtonen, M. A., Savolainen, M. J., and Hassinen, I. E.: Hormonal regulation of hepatic soluble phosphatidate phosphohydrolase. FEBS Lett. 99:162–166, 1979.Google Scholar
  201. Leung, N. N. Y., and Peters, T. J.: Palmitic acid oxidation and incorporation into triglyceride by needle liver biopsy specimens from control subjects and patients with alcoholic fatty liver disease. J. Clin. Sci. 71:253–260, 1986.Google Scholar
  202. Leung, N. N. Y., Cairns, S. T, and Peters, T. J.: Activities and subcellular distributions of hepatic lipases in control subjects and in patients with alcoholic fatty liver. J. Clin. Sci. 69:517–523,1985.Google Scholar
  203. Levy, R. I., Brensike, J. F., Epstein, S. E., Kelsey, S. F., Passamani, E. R., Richardson, J. M., Loh, I. K., Stone, N. J., Aldrich, R. F., Battaglini, J. W, Moriarty, D. J., Fisher, M. L., Friedman, L., Friedewald, W., and Detre, K. M.: The influence of changes in lipid values induced by choles-tyramine and diet on progression of coronary artery disease: Results of NHLBI Type II Coronary Intervention Study. Circulation 69:325–337, 1984.Google Scholar
  204. Lewis, P J., and Dollery, C. T.: Clinical pharmacology and potential of prostacyclin. Br. Med. Bull. 38:281–284, 1983.Google Scholar
  205. L’Huiller, J. R., Roudier, R., and Thuiller, J.: Evidence histologique de l’efficacité et de l’innocuitè de, l’oxygène hyperbare dans le traitement de l’intoxication éthylique expérimentale.Med. Pharmacol. Exp. 16:513–519, 1967.Google Scholar
  206. Liau, D. F, Hashim, S. A., Pierson, R. N., and Ryan, S. F: Alcohol-induced lipid change in the lung. J. Lipid Res. 22: 680–686, 1981.Google Scholar
  207. Lieber, C. S.: Metabolic effects produced by alcohol in the liver and other tissues. Adv. Intern. Med. 14:151–199, 1968.Google Scholar
  208. Lieber, C. S.: Alcohol and the liver. In: The Biological Basis of Medicine, Vol. 5 (E. E. Bittar, ed.), New York, Academic Press, pp. 317–344, 1969.Google Scholar
  209. Lieber, C. S.: Alcohol, protein metabolism, and liver injury. Gastroenterology 79:373–390, 1980.Google Scholar
  210. Lieber, C. S. (ed.): Medical Disorders of Alcoholism, Pathogenesis and Treatment. Philadelphia, W. B. Saunders Co., 1982.Google Scholar
  211. Lieber, C. S.: To drink (moderately) or not to drink? N. Engl. J. Med. 310:846–848, 1984.Google Scholar
  212. Lieber, C. S.: Alcohol and the Liver. In: Liver Annual-VI (J. L. Boyer and J. H. P. Wilson, eds.), Amsterdam, The Netherlands, Excerpta Medica, pp. 163–240, 1987.Google Scholar
  213. Lieber, C. S., and Davidson, C. S.: Some metabolic effects of ethyl alcohol. Am. J. Med. 33:319–327, 1962.Google Scholar
  214. Lieber, C. S., and DeCarli, L. M.: Study of agents for the prevention of the fatty liver produced by prolonged alcohol intake. Gastroenterology 50:316–322, 1966.Google Scholar
  215. Lieber, C. S., and DeCarli, L. M.: Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. Am. J. Clin. Nutr. 23:474–478, 1970a.Google Scholar
  216. Lieber, C. S., and DeCarli, L. M.: Reduced nicotinamide-adenine dinucleotide phosphate oxidase: Activity enhanced by ethanol consumption. Science 170:78–80, 1970b.Google Scholar
  217. Lieber, C. S., and Pignon, J. P.: Ethanol and lipids. In: Human Plasma Lipoproteins: Chemistry, Physiology and Pathology (J. C. Fruchart, and J. Shepherd, eds.), Berlin, Walter De Gruyter and Co., pp. 245–280, 1989.Google Scholar
  218. Lieber, C. S., and Rubin, E.: Alcoholic fatty liver in man on a high protein and low fat diet. Am. J. Med. 44:200–207, 1968.Google Scholar
  219. Lieber, C. S., and Schmid, R.: The effect of ethanol on fatty acid metabolism: Stimulation of hepatic fatty acid synthesis in vitro. J. Clin. Invest. 40:394–399, 1961.Google Scholar
  220. Lieber, C. S., and Spritz, N.: Effect of prolonged ethanol intake in man: Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J. Clin. Invest. 45:1400–1411, 1966.Google Scholar
  221. Lieber, C. S., Leevy, C. M., Stein, S. W, George, W. S., Cherrick, G. R., Abelmann, W. H., and Davidson, C. S.: Effect of ethanol on plasma frei fatty acids in man. J. Lab. Clin. Med. 59:826–832, 1962.Google Scholar
  222. Lieber, C. S., Jones, D. P, Mendelson, J., and DeCarli, L. M.: Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans. Assoc. Am. Physicians 76:289–300, 1963.Google Scholar
  223. Lieber, C. S., Jones, D. P, and DeCarli, L. M.: Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets. J. Clin. Invest. 44:1009–1021, 1965.Google Scholar
  224. Lieber, C. S., Spritz, N., and DeCarli, L. M.: Role of dietary, adipose and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J. Clin. Invest. 45:51–62, 1966a.Google Scholar
  225. Lieber, C. S., Spritz, N., and DeCarli, L. M.: Accumulation of triglycerides in heart and kidney after alcohol ingestion. J. Clin. Invest. 45:1041 (abstract), 1966b.Google Scholar
  226. Lieber, C. S., Lefevre, A., Spritz, N., Feinman, L., and DeCarli, L. M.: Difference in hepatic metabolism of long-and medium-chain fatty acids: The role of fatty acid chain length in the production of the alcoholic fatty liver. J. Clin. Invest. 46:1451–1460, 1967.Google Scholar
  227. Lieber, C. S., Spritz, N., and DeCarli, L. M.: Fatty liver produced by dietary deficiencies: Its pathogenesis and potentiation by ethanol. J. Lipid Res. 10:283–287, 1969.Google Scholar
  228. Lieber, C. S., DeCarli, L. M., Gang, H., Walker, G., and Rubin, E.: Hepatic effects of long-term ethanol consumption in primates. In: Medical Primatology, Part III (E. I. Goldsmith and J. Moor-Jankowski, eds.), Basel, Karger, pp. 270–278, 1972.Google Scholar
  229. Lieber, C. S., Teschke, R., Hasumura, Y., and DeCarli, L. M.: Differences in hepatic and metabolic changes after acute and chronic alcohol consumption. Fed. Proc. 34:2060–2074, 1975.Google Scholar
  230. Lombardi, B. P., Pani, P., and Schlunk, F. F.: Choline-deficiency fatty liver: Impaired release of hepatic triglycerides. J. Lipid Res. 9:437–446, 1968.Google Scholar
  231. Losowsky, M. S., Jones, D. P, Davidson, C. S., and Lieber, C. S.: Studies of alcoholic hyperlipemia and its mechanism. Am. J. Med. 35:794–803, 1963.Google Scholar
  232. Luoma, P. V., Sotaniemi, E. A., Pelkonen, R. O., and Ehnholm, C.: High-density lipoproteins and hepatic microsomal enzyme induction in alcohol consumers. Res. Commun. Chem. Pathol. Pharmacol. 37:91–96, 1982.Google Scholar
  233. Maciejko, J. J., Holmes, D. R., Kottke, B. A., Zinsmeister, A. R., Dinh, D. M., and Mao, S. J. T.: Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. N. Engl. J. Med. 309:385–389, 1983.Google Scholar
  234. Maillard, M. E., Sorrell, M. F, Volentine, G. D., and Tuma, D. J.: Impaired plasma membrane glycoprotein assembly in the liver following acute ethanol administration. Biochem. Biophys. Res. Commun. 123:951–958, 1984.Google Scholar
  235. Malloy, S.: Effect of adrenalectomy on ethanol and fat metabolism in the rat. Am. J. Physiol. 189:428–438, 1957.Google Scholar
  236. Malloy, S., and Bloch, J. L.: Role of hypophysis and adrenals in fatty infiltration of liver resulting from acute ethanol intoxication. Am. J. Physiol. 184:29–34, 1956.Google Scholar
  237. Malmendier, C. L., and Delcroix, C.: Effect of alcohol intake on high and low density lipoprotein metabolism in healthy volunteers. Clin. Chim. Acta 152:281–288, 1985.Google Scholar
  238. Malmendier, C. L., Mailier, E. L., Amerijckx, J. P., and Fischer, M. L.: Plasma levels of apolipoproteins A-I, A-II in alcoholism relation to the degree of histological liver damage, and to liver function tests. Acta Hepato-gasrroenterol. 30:236–239, 1983.Google Scholar
  239. Maquedano, A., Guzman, M., and Castro, J.: Dependence with nutritional status of the ethanol effects on fatty acid metabolism in rat hepatocytes. Int J. Biochem. 20:937–941, 1988.Google Scholar
  240. Marchetti, M., Ottani, V., Zanetti, P., and Puddu, P: Aspects of lipid metabolism in ethanol-induced fatty liver. J. Nutr. 95:607–611, 1968.Google Scholar
  241. Marin, G. A., Karjoo, M., Ward, N., and Rosato, E.: Effects of alcohol on biliary lipids in the presence of a chronic biliary fistula. Surg. Gynecol. Obstet. 141:352–356, 1975.Google Scholar
  242. Marmot, M. G., Rose, G., Shipley, M. J., and Thomas, B. J.: Alcohol and mortality: A u-shaped curve. Lancet 1:580–583, 1981.Google Scholar
  243. Marth, E., Cazzolato, G., Bon, B., Avogaro, P., and Kostner, G. M.: Serum concentrations of Lp(a) and other lipoprotein parameters in heavy alcohol consumers. Ann. Nutr. Metab. 26:56–62, 1982.Google Scholar
  244. Maruyama, S., Murawaki, Y., and Hirayama, C.: Effects of chronic ethanol administration on hepatic cholesterol and bile acid synthesis in relation to serum high density lipoprotein cholesterol in rats. Res. Commun. Chem. Pathol. Pharmacol. 53:3–21, 1986.Google Scholar
  245. Marzo, S., Ghirardi, P, Sardini, D., Prandini, B. D., and Albertini, A.: Serum lipids and total fatty acids in chronic alcoholic liver disease at different states of cell damage. Klin. Wochenschr. (Berlin) 48:949–950, 1970.Google Scholar
  246. Matsuda, Y., Baraona, E., Salaspuro, M., and Lieber, C. S.: Effects of ethanol on liver microtubules and Golgi apparatus: Possible role in altered hepatic secretion of plasma proteins. Lab. Invest. 41:455–463, 1979.Google Scholar
  247. Matsuzaki, S., and Lieber, C. S.: Increased susceptibility of hepatic mitochondria to the toxicity of acetaldehyde after chronic ethanol consumption. Biochem. Biophys. Res. Commun. 75:1059–1065, 1977.Google Scholar
  248. Mavrelis, P. G., Ammon, H. V, Gleysteen, J. J., Komorowski, R. A., and Charaf, U. K.: Hepatic free fatty acids in alcoholic liver disease and morbid’.obesity. Hepatology 3:226–231, 1983.Google Scholar
  249. McIntyre, N.: Plasma lipids and lipoproteins in liver disease. Gut 19:526–530, 1978.Google Scholar
  250. Mendelson, J. H., and Mellow, N. K.: Alcohol-induced hyperlipidemia and beta lipoproteins. Science 180:1372–1374, 1973.Google Scholar
  251. Mendenhall, C. L.: Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis. Am. J. Dig. Dis. 13:783–791, 1968.Google Scholar
  252. Mendenhall, C. L.: Origin of hepatic triglyceride fatty acids: Quantitative estimation of the relative contribution of linoleic acid by diet and adipose tissue in normal and ethanol-fed rats. J. Lipid Res. 13:177–183, 1972.Google Scholar
  253. Menghini, G.: L’aspect morpho-bioptique du foie de l’alcohoolique (non cirrhotique) et son évolution. Bull. Acad. Suisse Sci. Med. 16:36–52, 1960.Google Scholar
  254. Mezey, E., Potter, J. J., and Ammon, R. A.: Effect of ethanol administration on the activity of the hepatic lysosomal enzymes. Biochem. Pharmacol. 25:2263.-2267, 1976.Google Scholar
  255. Mezey, E., Potter, J. J., Slusser, R. J., Brandes, D., Romero, J., Tamura, T, and Halsted, C. H.: Effect of ethanol feeding on hepatic lysosomes in the monkey. Lab. Invest. 43:88–93, 1980.Google Scholar
  256. Mikkhailidis, D. P., Jeremy, J. Y., Barradas, M. A., Green, N., and Dandona, P: Effect of ethanol on vascular prostacyclin (prostaglandin 12) synthesis, platelet aggregation, and platelet thromboxane release. Br. Med. J. 287:1495–1498, 1983.Google Scholar
  257. Miller, G. J., and Miller, N. E.: Plasma high-density-lipoprotein concentration and development of ischaemic heart disease. Lancet 1:16–19, 1975.Google Scholar
  258. Miller, N. E., Førde, O. H., Thelle, D. S., and Mjøs, O. D.: The Tromsø heart study. High-density lipoprotein and coronary heart disease: A prospective case-control study. Lancet 1: 965–967, 1977.Google Scholar
  259. Miller, N. E., Hammett, F., Saltissi, S., Rao, S., Van Zeller, H., Coltart, J., and Lewis, B.: Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins. Br. Med. J. 282:1741–1744, 1981.Google Scholar
  260. Miller, N. E., La Ville, A., and Crook, D.: Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit. Nature 314:109–111, 1985.Google Scholar
  261. Moncada, S., and Vane, J. R.: Pharmacology and endogenous roles of prostacyclin endoperoxides, thromboxane A2 and prostacyclin. Pharmacol. Rev. 30:293–297, 1979.Google Scholar
  262. Monroe, P., Viahcevic, Z. R., and Swell, L.: Effects of acute and chronic ethanol intake on bile acid metabolism. Alcoholism: Clin. Exp. Res. 5:92–100, 1981.Google Scholar
  263. Mordasini, R., Kaffarnik, H., Schneider, J., and Riesen, W: Alkohol and Plasmalipoproteine im akut and Langzeitversuch. Schweiz. Med. Wochenschr. 112:1928–1931, 1982.Google Scholar
  264. Morgan, J. C., and Di Luzio, N. R.: Inhibition of the acute ethanol-induced fatty liver by pyrazole. Proc. Soc. Exp. Biol. Med. 134:462–468, 1970.Google Scholar
  265. Muller, P, Fellin, R., Lamprecht, J., Agostini, B., Wieland, H., Rost, W, and Seidel, D.: Hypertriglyceridaemia secondary to liver disease. Eur. J. Clin. Invest. 4:419–428, 1974.Google Scholar
  266. Nervi, A. M., Peluffo, R. O., Brenner, R. R., and Leikin, A. I.: Effect of ethanol administration on fatty acid desaturation. Lipids 15:263–268, 1980.Google Scholar
  267. Nestel, P. J.: Some clinical and chemical manifestations of alcohol-induced hyperlipemia. Australas Ann. Med. 16:139–143, 1967.Google Scholar
  268. Nikkilä, E. A., and Ojala, K.: Role of hepatic L-a-glycerolphosphate and triglyceride synthesis in production of fatty liver by ethanol. Proc. Soc. Exp. Biol. Med. 113:814–817, 1963.Google Scholar
  269. Nikkilä, E. A., Taskinen, M.-R., and Huttunen, J. K.: Effect of acute ethanol load on postheparin plasma lipoprotein lipase and hepatic lipase activities and intravenous fat tolerance. Horm. Metal). Res. 10:220–223, 1978.Google Scholar
  270. Nikkilä, E. A., Kuusi, T., and Taskinen, M. R.: Role of lipoprotein lipase and hepatic endothelial lipase in the metabolism of high density lipoproteins: A novel concept on cholesterol transport in HDL cycle. In: Metabolic Risk Factors in Ischemic Cardiovascular Disease (L. A. Carlson and B. Pernow, eds.), New York, Raven, pp. 205–215, 1982.Google Scholar
  271. Nilsson-Ehle, P, Carlstrom, S., and Belfrage, P.: Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects. Lipids 13:433–437, 1978.Google Scholar
  272. Norbeck, H.-E., Walldius, G., Carlson, L. A., and Ideström, C.-M.: Serum lipoprotein abnormalities and adipose tissue metabolism in severe alcoholism. In: Metabolic Effects of Alco-hol (P Avogaro, C. R. Sirtori, and E. Tremoli, eds.), The Netherlands, Elsevier/North-Holland Biomedical Press, pp. 215–225, 1979.Google Scholar
  273. Nordmann, R., Ribiere, C., Rouach, H., and Nordmann, J.: Paradoxical effects of pyrazole on acute ethanol-induced fatty liver. Rev. Eur. Etud. Clin. Biol. 17:592–596, 1972.Google Scholar
  274. Ockner, R. K., Hughes, E B., and Isselbacher, K. J.: Very low density lipoproteins in intestinal lymph: Origin, composition and role in lipid transport in the fasting state. J. Clin. Invest. 48:2079–2088, 1969.Google Scholar
  275. Ockner, R. K., Mistilis, S. P, Poppenhausen, R. B., and Stiehl, A. E: Ethanol induced fatty liver: Effect of intestinal lymph fistula. Gastroenterology 64:603–609, 1973.Google Scholar
  276. Ockner, R. K., Manning, J. A., and Kane, J. P.: Fatty acid binding protein: Isolation from rat liver, characterization, and immunochemical quantification. J. Biol. Chem. 257:7872–7878, 1982.Google Scholar
  277. Olson, R. E.: In: Modern Nutrition in Health and Disease (M. G. Wohl and R. S. Goodhart, eds.), Philadelphia, Lea and Febiger, pp. 1037–1050, 1964.Google Scholar
  278. Ontko, J. A.: Effects of ethanol on the metabolism of free fatty acids in isolated liver cells. J. Lipid Res. 14:78–86, 1973.Google Scholar
  279. Ostrander, L. D., Jr., Johnson, B. C., and Block, W. D.: Relationship of alcohol intake to lipid levels in men from a general population. Circulation 44:11–59, 1971.Google Scholar
  280. Ostrander, L. D., Jr., Lamphiear, D. E., Block, W. D., Johnson, B. C., Ravenscroft, C., and Epstein, F. H.: Relationship of serum lipid concentrations to alcohol consumption. Arch. Intern. Med. 134:451–456, 1974.Google Scholar
  281. Papadopoulus, N. M., and Charles, M. A.: Serum lipoprotein patterns in liver disease. Proc. Soc. Exp. Biol. Med. 134: 797–799,1970.Google Scholar
  282. Patek, A. J., and Earampamoorthy, S.: Serum lipids in alcoholic patients with and without cirrhosis of the liver, with particular reference to endogenous familial hypertriglyceridemia. Am. J. Clin. Nutr. 29:1122–1126, 1976.Google Scholar
  283. Pell, S., and D’Alonzo, C. A.: A five-year mortality study of alcoholics. J. Occup. Med. 15:120–125, 1973.Google Scholar
  284. Phillips, G. B., and Davidson, C. S.: Nutritional aspects of cirrhosis in alcoholism: Effect of a purified diet supplemented with choline. Ann. N.Y. Acad. Sci. 57:812–830, 1954.Google Scholar
  285. Pignon, J. P, Bailey, N. C., Baraona, E., and Lieber, C. S.: Fatty acid binding protein: A major contributor to the ethanol-induced increase in liver cytosolic proteins in the rat. Hepatology 7:865–871, 1987.Google Scholar
  286. Poggi, M., and Di Luzio, N. R.: The role of liver and adipose tissue in the pathogenesis of the ethanol induced fatty liver. J. Lipid Res. 5:437–441, 1964.Google Scholar
  287. Polokoff, M. A., and Bell, R. M.: Limited palmitoyl-CoA penetration into microsomal vesicles as evidenced by a highly latent ethanol acyltransferase activity. J. Biol. Chem. 253: 7173–7178, 1978.Google Scholar
  288. Polokoff, M. A., Simon, T. J., Harris, R. A., Simon, F. R., and Iwahashi, M.: Chronic ethanol increases liver plasma membrane fluidity. Biochemistry 24:3114–3120, 1985.Google Scholar
  289. Popham, R. E., Schmidt, W, and Israel, Y.: Variation in mortality from ischemic heart disease in relation to alcohol and milk consumption. Med. Hypotheses 12:321–329, 1983.Google Scholar
  290. Popper, H., and Lieber, C. S.: Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am. J. Pathol. 98:695–716, 1980.Google Scholar
  291. Porta, E. A., Hartroft, W. S., and de la Iglesia, F.A.: Hepatic changes associated with chronic alcoholism in rats. Lab. Invest. 14:1437–1455, 1965.Google Scholar
  292. Post, J., Benton, J. G., Breakstone, R., and Hoffman, J.: Effects of diet and choline on fatty infiltration of the human liver. Gastroenterology 20:403–410, 1952.Google Scholar
  293. Poynard, T., Abella, A., Pignon, J. P, Naveau, S., Poitrine, A., Agostini, H., Zourabichvili, O., Leluc, R., and Chaput, J. C.: Apolipoprotein A-I (APO-A-I) and high-density-lipoprotein cholesterol (DLC) concentrations are elevated in alcoholic patients with liver steatosis. Gastroenterolog 88:1685 (abstract), 1985.Google Scholar
  294. Poynard, T., Abella, A., Pignon, J.-P., Naveau, S., Leluc, R., and Chaput, J.-C.: Apolipoprotein AI and alcoholic liver disease. Hepatology 6:1391–1395, 1986.Google Scholar
  295. Prancan, A. V, and Nakano, J.: Effect of pyrazole on conversion of ethanol and acetate into lipids in rat liver. Res. Commun. Chem. Pathol. Pharmacol. 4:181–191, 1972.Google Scholar
  296. Pritchard, P. H., Bowley, M., Burditt, S. D., Cooling, J., Glenny, H. D., Lawson, N., Sturton, k. G., and Brindley, D. N.: The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue. Biochem. J. 166:639–642, 1977.Google Scholar
  297. Puchois, P., Fontan, M., Gentilini, J.-L., Gelez, P, and Fruchard, J. C.: Serum apolipoprotein A-H, a biochemical indicator of alcohol abuse. Clin. Chim. Acta 185:185–189, 1984.Google Scholar
  298. Radomski, M. W, and Wood, J. D.: The lipotropic action of cold. I. The influence of cold and choline deficiency on liver lipids of rats at different intakes of dietary methionine. Can. J. Physiol. Pharmacol. 42:679–777, 1964.Google Scholar
  299. Rao, G. A., Lew, G., and Larkin, E. C.: Alcohol ingestion and levels of hepatic fatty acid synthetase and stearoyl-CoA desaturase activities in rats. Lipids 19:151–153, 1984.Google Scholar
  300. Rebouças, G., and Isselbacher, K. J.: Studies on the pathogenesis of the ethanol-induced fatty liver. 1. Synthesis and oxidation of fatty acids by the liver. J. Clin. Invest. 40:1355–1362, 1961.Google Scholar
  301. Redgrave, T. G., and Martin, G.: Effects of chronic ethanol consumption on the catabolism of chylomicron triacylglycerol and cholesteryl ester in the rat. Atherosclerosis 28: 69–80,1977.Google Scholar
  302. Riesen, W. F, Mordasini, R., Salzmann, C., Theler, A., and Gurtner, H. P: Apoproteins and lipids as discriminators of severity of coronary heart disease. Atherosclerosis 37:157–162, 1980.Google Scholar
  303. Reitz, R. C.: A possible mechanism for the peroxidation of lipids due to chronic ethanol ingestion. Biochim. Biophys. Acta 380:145–154, 1975.Google Scholar
  304. Rottenberg, H., Waring, A., and Rubin, E.: Tolerance and cross-tolerance in chronic alcoholics: Reduced membrane binding of ethanol and other drugs. Science 213:583–585, 1981.Google Scholar
  305. Rouach, H., Clement, M., Orfanelli, M. T., Janvier, B., and Nordmann, R.: Fatty acid composition of rat liver mitochondria, phospholipids during ethanol inhalation. Biochim. Biophys. Acta 795:125–129, 1984.Google Scholar
  306. Rubin, E., and Lieber, C. S.: Early fine structural changes in the human liver induced by alcohol. Gastroenterology 52:1–13, 1967.Google Scholar
  307. Rubin, E., and Lieber, C. S.: Alcohol induced hepatic injury in non-alcoholic volunteers. N. Engl. J. Med. 278:869–876, 1968.Google Scholar
  308. Rubin, E., Beattie, D. S., Toth, A., and Lieber, C. S.: Structural and functional effects of ethanol on hepatic mitochondria. Fed. Proc. 31:131–140, 1972.Google Scholar
  309. Rudel, L. L., Leathers, C. W, Bond, M. G., and Bullock, B. C.: Dietary ethanol-induced modifications in hyperlipoproteinemia and atherosclerosis in non-human primates (Macaca nemestrina). Atherosclerosis 1:144–155, 1981.Google Scholar
  310. Sabesin, S. M., and Weidman, S. W: Lipoprotein profiles in chronic alcoholics: Use of high-density lipoprotein subspecies levels to differentiate subpopulations. Hepatology 4: 137–738, 1984.Google Scholar
  311. Sabesin, S. M., Hawkins, H. L., Kuiken, L., and Ragland, J. B.: Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease. Gastroenterology 72:510–518, 1977.Google Scholar
  312. Sachan, D. S., Rhew, T. H., and Ruark, R. A.: Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver. Am. J. Clin. Nutr. 39:738–744, 1984.Google Scholar
  313. Salaspuro, M. P., Ross, W. A., Jayatilleke, E., Shaw, S., and Lieber, C. S.: Attenuation of the ethanol induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequences in vivo and in vitro. Hepatology 1: 33–38, 1981.Google Scholar
  314. Sanchez-Graig, M., and Annis, H. M.: Gamma-glutamyl trans-peptidase and high-density lipoprotein cholesterol in male problem drinkers: Advantages of a composite index for predicting alcohol consumption. Alcoholism. Clin. Exp. Res. 5: 540–544, 1981.Google Scholar
  315. Sane, T., Nikkilä, E. A., Taskinen, M.-R., Välimäki, M., and Ylikahri, R.: Accelerated turnover of very low density lipoprotein triglycerides in chronic alcohol users: A possible mechanism for the up-regulation of high density lipoprotein by ethanol. Atherosclerosis 53:185–193, 1984.Google Scholar
  316. Savolainen, M. J.: Stimulation of hepatic phosphatidate phosphohydrolase activity by a single dose of ethanol. Biochem. Biophys. Res. Commun. 75:511–518, 1977.Google Scholar
  317. Savolainen, M. J., and Hassinen, I. E.: Mechanisms for the effects of ethanol on hepatic phosphatidate phosphohydrolase. Biochem. J. 176:885–892, 1978.Google Scholar
  318. Savolainen, M. J., and Hassinen, I. E.: Effect of ethanol on hepatic phosphatidate phosphohydrolase: dose-dependent enzyme induction and its abolition by adrenalectomy and pyrazole treatment. Arch. Biochem. Biophys. 201:640–645, 1980.Google Scholar
  319. Savolainen, M. J., Hiltunen, J. K., and Hassinen, I. E.: Effect of prolonged ethanol ingestion on hepatic lipogenesis and related enzyme activities. Biochem. J. 164:169–177, 1977a.Google Scholar
  320. Savolainen, M. J., Jauhonen, V. P., and Hassinen, I. E.: Effects of clofibrate on ethanol-induced modifications in liver and adipose tissue metabolism: Role of hepatic redox state and hormonal mechanisms. Biochem. Pharmacol. 26:425–431, 1977b.Google Scholar
  321. Savolainen, M. J., Baraona, E., Pikkarainen, P., and Lieber, C. S.: Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.J. Lipid Res. 25: 813–820, 1984.Google Scholar
  322. Savolainen, M., Baraona, E., Leo, M. A., and Lieber, C. S.: Pathogenesis of the hypertriglyceridemia at early stages of alcoholic liver injury in the baboon. J. Lipid Res. 27:1073–1083, 1986.Google Scholar
  323. Savolainen, M. J., Baraona, E., and Lieber, C. S.: Acetaldehyde binding increases the catabolism of rat serum low-density lipoproteins. Life Sci. 40:841–846, 1987.Google Scholar
  324. Schaefer, E. J., and Levy, R. I.: Pathogenesis and management of lipoprotein disorders. N. Engl. J. Med. 312:1300–1310, 1985.Google Scholar
  325. Schapiro, R. H., Scheig, R. L., Drummey, G. D., Mendelson, J. H., and Isselbacher, K. J.: Effect of prolonged ethanol ingestion on transport and metabolism of lipids in man. N. Engl. J. Med.272:610–615, 1965.Google Scholar
  326. Schneider, J., Panne, E., Braun, H., Mordasi, R., and Kaffarnik, H.: Ethanol-induced hyperlipoproteinemia. J. Lab. Clin. Med. 101:114–122, 1983.Google Scholar
  327. Schuller, A., Moscat, J., Diez, E., Fernandez-Checa, J. C., Gavilanes, F. C., and Municio, A. M.: Functional properties of isolated hepatocytes from ethanol-treated rat liver. Hepatology 5:677–682, 1985.Google Scholar
  328. Seakins, A., and Waterlow, J. C.: Effect of a low-protein diet on the incorporation of amino acids into rat serum lipoproteins. Biochem. J. 129:793–795, 1972.Google Scholar
  329. Selmer, J., and Grunnet, N.: Ethanol metabolism and lipid synthesis by isolated liver cells from fed rats. Biochim. Biophys. Acta 428:123–137, 1976.Google Scholar
  330. Shaper, A. G., Wannamethee, G., and Walker, M.: Alcohol and mortality in British men: Explaining the U-shaped curve. Lancet 2:1267–1273, 1988.Google Scholar
  331. Shaw, W: Possible role of lysolecithins and nonesterified fatty acids in the pathogenesis of Reye’s syndrome, sudden infant death syndrome, acute pancreatitis, and diabetic ketoacidosis. Clin. Chem. 31:1109–1115, 1985.Google Scholar
  332. Sigurdsson, G., Nicoll, A., and Lewis, B.: The metabolism of low density lipoprotein in endogenous hypertriglyceridaemia. Eur. J. Clin. Invest. 6:167–177, 1976.Google Scholar
  333. Sirtori, C. R., Agradi, E., and Mariani, C.: Hyperlipoproteinemia in alcoholic subjects. Pharmacol. Res. Commun. 5:81–85, 1973.Google Scholar
  334. Sorrell, M. F, Baker, H., Mina, D. J., Frank, O. M., and Barak, A. J.: Potentiation of ethanol fatty liver in rats by chronic administration of nicotinic acid. Biochim. Biophys. Acta 450:231–238,1976.Google Scholar
  335. Spritz, N., and Lieber, C. S.: Decrease of ethanol-induced fatty liver by ethyl-a-p-chlorophenoxyisobutyrate. Proc. Soc. Exp. Biol. Med. 12:147–149, 1966.Google Scholar
  336. Stanko, R. T., Mendelow, H., Shinozuka, H., and Adibi, S. A.: Prevention of alcohol-induced fatty liver by natural metabolites and riboflavin. J. Lab. Clin. Med. 91:228–235, 1978.Google Scholar
  337. Stein, Y., and Schapiro, B.: Glyceride synthesis by microsome fractions of rat liver. Biochim. Biophys. Acta 30:271–277, 1958.Google Scholar
  338. Strakosch, C. R., Jeffreys, D. B., and Keen, H.: Blockade of chloiplopamide alcohol flush by aspirin. Lancet 1:394–396, 1980.Google Scholar
  339. Sturton, R. G., Pritchard, P. H., Han, L.-Y., and Brindley, D. N.: The involvement of phosphatidate phosphohydrolase and phospholipase A activities in the control of hepatic glycerolipid synthesis. Biochem. J. 174:667–670, 1978.Google Scholar
  340. Sturton, R. G., Butterwith, S. C., Burditt, S. L., and Brindley, D. N.: Effects of starvation, corticotropin injection and ethanol feeding on the activity and amount of phosphatidate phosphohydrolase in rat liver. FEBS Lett.126:297–300, 1981.Google Scholar
  341. Summerskill, W. H. J., Wolfe, S. J., and Davidson, C. S.: Response to alcohol in chronic alcoholics with liver disease: Clinical, pathological and metabolic changes. Lancet. 1:335–343, 1957.Google Scholar
  342. Sun, G. Y., and Sun, A. Y.: Ethanol and membrane lipids. Alcoholism: Clin. Exp. Res. 9:164–180, 1985.Google Scholar
  343. Takeuchi, N., Ito, M., and Yamamura, Y.: Esterification of cholesterol and hydrolysis of cholesteryl ester in alcohol induced fatty liver of rats. Lipids 9:353–357, 1974.Google Scholar
  344. Talbot, G. D., and Keating, B. M.: Effects of preprandial whiskey on postalimentary lipemia. Geriatrics 17:802–808, 1962.Google Scholar
  345. Tappel, A. L.: Lipid peroxidation damage to cell components. Fed. Proc. 33:1870–1874, 1973.Google Scholar
  346. Taraschi, T. E, and Rubin, E.: Biology of disease. Lab. Invest. 52:120–131, 1985.Google Scholar
  347. Taskinen, M.-R., and Nikkilä, E. A.: Nocturnal hypertriglyceridemia and hyperinsulinemia following moderate evening intake of alcohol. Acta Med. Scand. 202:173–177, 1977.Google Scholar
  348. Taskinen, M.-R., Välimäki, M., Nikkilä, E. A., Kuusi, T., Ehnholm, C., and Ylikahri, R.: High density lipoprotein subfractions and postheparin plasma lipases in alcoholic men before and after ethanol withdrawal. Metabolism 31:1168–1174, 1982.Google Scholar
  349. Taskinen, M.-R., Välimäki, M., Nikkilä, E. A., Kuusi, T, and Ylikahri, R.: Sequence of alcohol-induced initial changes in plasma lipoproteins. Metabolism 34:112–119, 1985.Google Scholar
  350. Thornton, J., Symes, C., and Heaton, K.: Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol. Lancet 2:819–822, 1983.Google Scholar
  351. Tijburg, L. B. M., Maquedano, A., Bijleveld, C., Guzman, M., and Geelen, M. J. H.: Effects of ethanol feeding on hepatic lipid synthesis. Arch. Biochem. Biophys. 267:568–579, 1988.Google Scholar
  352. Topping, D. L., Weller, R. A., Nader, C. J., Calvert, G. D., and Illman, R. J.: Adaptive effects of dietary ethanol in the pig: Changes in plasma high-density lipoproteins and fecal steroid excretion and mutagenicity. Am. J. Clin. Nutr. 36:245–250, 1982.Google Scholar
  353. Truitt, E. B., Gaynor, C. R., and Mehl, D. L.: Aspirin attenuation of alcohol-induced flushing and intoxication in Oriental and Occidental subjects. Alcohol Alcohol. Suppl. 1:595–599, 1987.Google Scholar
  354. Uthus, E. O., Skurdal, D. N., and Cornatzer, W. E.: Effect of ethanol ingestion on choline phosphotransferase and phosphatidyl ethanolamine methyltransferase activities in liver microsomes. Lipids 11:641–644, 1976.Google Scholar
  355. Vasdev, S. C., Subrahmanyam, D., Chakravarti, R. N., and Wahi, P. L.: Effect of chronic ethanol feeding on the major lipids of red blood cells, liver, and heart of rhesus monkey. Biochim. Biophys. Acta 369:323–330, 1974.Google Scholar
  356. Venkatesan, S., Leung, N. W. Y., and Peters, T. J.: Fatty acid synthesis in vitro by liver tissue from control subjects and patients with alcoholic liver disease. Clin. Sci. 71:723–728, 1986.Google Scholar
  357. Verdy, M., and Gattereau, A.: Ethanol, lipase activity, serum-lipid level. Am. J. Clin. Nutr. 20:997–1004, 1967.Google Scholar
  358. Volwiler, W., Jones, C. M., and Mallory, T.B.: Criteria for the measurement of result of treatment in fatty cirrhosis. Gastroenterology 11:164–182, 1948.Google Scholar
  359. Von Platt, U., Stein, U., and Heissmeyer, H.: Catabolic mucopolysaccharide-protein metabolism in rat liver following administration of ethanol. Z. Klin. Chem. Klin. Biochem. 9:126–129, 1971.Google Scholar
  360. Wang, D. L., and Reitz, R. C.: Ethanol ingestion and polyunsaturated fatty acids: Effects on the acyl-CoA desaturases. Alcoholism: Clin. Exp. Res. 7:220–226, 1983.Google Scholar
  361. Warembourg, H., Biserte, G., Jaillard, J., Sezille, G., and Scher pereel, P: Changes in serum and hepatic lipids induced by alcohol during chronic ethyl alcohol poisoning in rabbits. Rev. Eur. Etud. Clin. Biol. 15:649–653, 1970.Google Scholar
  362. Waring, A. J., Rottenberg, H., Ohnishi, T, and Rubin, E.: Membranes and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol. Proc. Natl. Acad. Sci. U.S.A. 78:2582–2586, 1981.Google Scholar
  363. Weidman, S. W., Ragland, J. B., and Sabesin, S. M.: Plasma lipoprotein composition in alcoholic hepatitis: Accumulation of apolipoprotein E-rich high density lipoprotein and preferential reappearance of “light”-HDL during partial recovery. J. Lipid Res. 23:556–569, 1982.Google Scholar
  364. Willet, W, Hennekens, C. H., Siegel, A. J., Adner, M. M., and Castelli, W. P.: Alcohol consumption and high density lipoprotein cholesterol in marathon runners. N. Engl. J. Med. 303:1159–1161, 1980.Google Scholar
  365. Williams, P T, Kraus, R. M., Wood, P. D., Albers, J. J., Dreon, D., and Ellsworth, N.: Associations of diet and alcohol intake with high-density lipoprotein subclasses. Metabolism 34:524–530,1985.Google Scholar
  366. Wilson, D. E., Schreibman, P. H., Brewster, A. C., and Arky, R. A.: The enhancement of alimentary lipemia by ethanol in man. J. Lab. Clin. Med. 75:264–274, 1970.Google Scholar
  367. Wilson, J. S., Colley, P. W, Sasula, L., Pirola, R. C., Chapman, B. A., and Somer, J. B.: Alcohol causes a fatty pancreas: A rat model of ethanol-induced pancreatic steatosis. Alcoholism: Clin. Exp. Res. 6:117–121, 1982.Google Scholar
  368. Windmueller, H. G., Herbert, P.N., and Levy, R. I.: Biosynthesis of lymph and plasma lipoprotein apoproteins by isolated perfused rat liver and intestine. J. Lipid Res. 14:215–223, 1973.Google Scholar
  369. Wolfe, B. M., Havel, J. R., Marliss, E. B., Kane, J. P., Seymour, J., and Ahuja, S. P.: Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men. J. Clin. Invest. 57:329–340, 1976.Google Scholar
  370. Yamada, S., and Lieber, C. S.: Decrease in microviscosity and cholesterol content of rat liver plasma membranes after chronic ethanol feeding. J. Clin. Invest. 74:2285–2289, 1984.Google Scholar
  371. Yano, K., Rhoads, G. G., and Kagan, A.: Coffee, alcohol, and risk of coronary heart disease among Japanese men living in Hawaii. N. Engl. J. Med. 297:405–409, 1977.Google Scholar
  372. Ylikahri, R.: Ethanol-induced changes in hepatic alpha-glycerophosphate and triglyceride concentrations in normal and thyroxine-treated rats. Metabolism 19:1036–1045, 1970.Google Scholar
  373. Zeichner, A., Feuerstein, M., Swartzman, L., and Reznick, E.: Acute effects of alcohol on cardiovascular reactivity to stress in type A (coronary prone) businessmen. In: Stress and Alcohol Use (L. A. Pohorecky, and J. Brick, eds.), New York, Elsevier Science, pp. 353–368, 1983.Google Scholar
  374. Zieve, L.: Jaundice, hyperlipemia, and hemolytic anemia: A heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann. Intern. Med. 48:471–496, 1958.Google Scholar
  375. Zysset, T., Polokoff, M. A., and Simon, F. R.: Effect of chronic ethanol administration on enzyme and lipid properties of liver plasma membranes in long and short sleep mice. Hepatology 5:531–537, 1985.Google Scholar

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