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Medical and Nutritional Complications of Alcoholism pp 531–563Cite as

Biological Markers of Alcoholism

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Abstract

A biological marker of ethanol consumption would be a valuable tool in the diagnosis and treatment of alcohol-ism. There are several areas of potential clinical applica-tion. First, a biological marker would be useful for the early detection of alcoholism, as many patients do not seek medical attention at an early stage (Clark, 1981). Previous studies have demonstrated the medical and social advantages of early intervention in the treatment of alcoholism (Reiff, 1985; Paredes, 1985). In addition, a biological marker would improve the monitoring of sobriety in alcoholics undergoing treatment. Furthermore, many patients who are suffering from a disease in which alcoholism is the suspected etiological agent (e.g., chronic pancreatitis, cirrhosis) fail to give an accurate history of their alcohol consumption. These patients are then subjected to an exhaustive diagnostic workup to rule out other etiological factors. A reliable biological marker of alcoholism would expedite the diagnostic workup and perhaps avoid invasive procedures (e.g., endoscopic retrograde pancreatography, liver biopsy). Finally, selected patients with alcohol-induced liver disease may become candidates for liver transplantation if there is a proven record of abstinence (Maddrey and Van Thiel, 1988); a reliable biological marker would provide objective verification of absti-nence and thus improve the selection process.

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Rosman, A.S., Lieber, C.S. (1992). Biological Markers of Alcoholism. In: Medical and Nutritional Complications of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3320-7_18

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