Abstract
Cerebral ischemia—the most prevalent form of clinical stroke—is a medical problem of the first magnitude. Despite rather convincing evidence of declining incidence of and mortality from stroke over the past decades (Scheinberg, 1988), it remains the third leading cause of death in the United States, as well as the major source of chronic disability, whose cost is reckoned in billions of dollars per annum and whose emotional impact is devastating (Hachinski and Norris, 1985). Traditional therapeutic approaches, largely supportive and directed at systemic factors, have tended to create a nihilistic attitude toward the potential for effective therapy of this disorder. This attitude is now changing as a result of impressive scientific advances, often carried out at a very basic level, that are shedding light on basic stroke pathomechanisms and are suggesting promising therapeutic approaches, some of which are now beginning to enter the clinical arena.
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Ginsberg, M.D., Braquet, P., Bazan, N.G. (1992). Introduction Current Biochemical and Molecular Approaches to the Study of Cerebral Ischemia. In: Bazan, N.G., Braquet, P., Ginsberg, M.D. (eds) Neurochemical Correlates of Cerebral Ischemia. Advances in Neurochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3312-2_1
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