The Interdigital Spaces of the Chick Leg Bud as a Model for Analysing Limb Morphogenesis and Cell Differentiation
Normal embryonic development is not a linear process of cell and tissue growth and differentiation (Hurle, 1988). There are many examples in which an early embryonic structure undergoes a reshaping process involving a substantial phenomenon of cell death. In some cases the tissue loss affects to fully formed organs which play a transitory functional role in the developing individual. This is the case of the loss of the tail in the developing anura amphibia during metamorphosis. In other cases cell death appears closely linked to morphogenesis an appears to play an sculpturing role for the achievement of the final shape of a developing structure. This appears to be the case in “interdigital cell death” occurring during morphogenesis of the digits of the amniote embryos.
KeywordsMigration Magnesium Penicillin Trypsin Streptomycin
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- Gasseling, M.T., & Saunders, J. W. Jr. (1964). Effect of the “Posterior Necrotic Zone” of the early chick wing bud on the pattern andsymmetry of limb outgrowth.Amer. Zool.,4:303–304.Google Scholar
- Hurle J. M. (1988). Cell death in developing systems. Meth.Achiev.exp. Pathol.vol. 13:Kinetics and Patterns of Necrosis (G. Jasmin ed.) pp 55–86. Karger.Basel.Google Scholar
- Meinhardt, H. (1982). Models of biological pattern formation. Academic Press. London.Google Scholar
- Smith, S. M., Pang, K., Sundin, O., Wedden, S. E., Thaller, C. & Eichele, G. (1989). Molecular approaches to vertebrate limb morphogenesis. Development suppl., 121–131.Google Scholar
- Solursh, M., Singley, C. T., & Reiter, R. S. (1981). The influence of epithelia on cartilage and loose connective tissue formation by limb mesenchyme cultures. Dev. Biol., 86: 471–482.Google Scholar
- Tickle C. (1980). The polarising region and limb development. In: “Development of Mammals vol. 4 ” (M. H. Johnson ed.) pp. 101–136. Elshevier/North Holland Biomed. Press. Amsterdam.Google Scholar
- Wolpert, L. (1989). Positional information revisited. Development supp. 3–12.Google Scholar