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Role of the Transforming Growth Factor-β (TGF-β) Family, Extracellular Matrix, and GAP Junctional Communication in Limb Cartilage Differentiation

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Developmental Patterning of the Vertebrate Limb

Part of the book series: NATO ASI Series ((NSSA,volume 205))

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Abstract

The differentiation of limb mesenchymal cells into chondrocytes involves a sequential series of regulatory events mediated in part by extracellular matrix macromolecules, peptide growth factors, cell-cell and cell-matrix interactions, cytoskeletal reorganization, and intracellular second messengers such as cAMP. In the present manuscript we describe some of our current studies on the role of and the possible relationship between the TGF-β family of growth factors and extracellular matrix and cell surface molecules including the membrane-intercalated proteoglycan, syndecan in the regulation of chick limb cartilage differentiation. We also describe studies indicating that intercellular communication via gap junctions may be involved in the regulation of chondrogenesis.

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Author information

Authors and Affiliations

  1. Department of Anatomy, University of Connecticut Health Center, Farmington, CT, 06030, USA

    Robert A. Kosher, Eileen F. Roark, Stephen E. Gould & Caroline N. D. Coelho

Authors
  1. Robert A. Kosher
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  2. Eileen F. Roark
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  3. Stephen E. Gould
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  4. Caroline N. D. Coelho
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Editor information

Editors and Affiliations

  1. University College of Wales, Aberystwyth, Wales, UK

    J. Richard Hinchliffe

  2. University of Cantabria, Santander, Spain

    Juan M. Hurle

  3. National Institute for Medical Research, London, UK

    Dennis Summerbell

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© 1991 Springer Science+Business Media New York

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Kosher, R.A., Roark, E.F., Gould, S.E., Coelho, C.N.D. (1991). Role of the Transforming Growth Factor-β (TGF-β) Family, Extracellular Matrix, and GAP Junctional Communication in Limb Cartilage Differentiation. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_31

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  • DOI: https://doi.org/10.1007/978-1-4615-3310-8_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6457-3

  • Online ISBN: 978-1-4615-3310-8

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