Abstract
Viroids are the smallest autonomously replicating pathogenic agents yet described.1 Viroids are low molecular weight RNAs (1.1–1.3 × 105) that can be isolated from certain species of plants afflicted with specific diseases. Although viroids have been discovered because they cause symptoms in some hosts, they are often replicated in other hosts without causing obvious damage.
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References
T. O. Diener, Potato spindle tuber “virus”. IV. A replicating, low molecular weight RNA, Virology 45:411 (1971).
H. J. Gross, H. Domdey, C. Lossow, P. Jank, M. Raba, H. Alberty, and H. L. Sänger, Nucleotide sequence and secondary structure of potato spindle tuber viroid, Nature 273:203 (1978).
D. Riesner, K. Henco, U. Rokohl, G. Klotz, A. K. Kleinschmidt, H. Domdey, P. Jank, H. J. Gross, and H. L. Sänger, Structure and structure formation of viroids, J. Mol. Biol. 133:85 (1979).
R. W. Hammond and R. A. Owens, Mutational analysis of potato spindle tuber viroid reveals complex relationships between structure and infectivity, Proc. Natl. Acad. Aci. USA 84:3967 (1987).
P. Loss, M. Schmitz, G. Steger, and D. Riesner, Formation of a thermodynamically metastable structure containing hairpin II is critical for infectivity of potato spindle tuber viroid RNA, EMBO J. 10:719 (1991).
P. Keese and R. H. Symons, Domains in viroids: evidence of intermolecular RNA rearrangements and their contribution to viroid evolution, Proc. Natl. Acad. Sci. USA 82:4582 (1985).
G. Steger, H. Hofmann, J. Fortsch, H. J. Gross, J. W. Randies, H. L. Sänger, and D. Riesner, Conformational transitions in viroids and virusoids: comparison of results from energy minimization algorithm and from experimental data, J. Biomol. Struct. Dynam. 2:543 (1984).
M. Schnölzer, B. Haas, K. Ramm, H. Hofmann, and H.L. Sänger, Correlation between structure and pathogenicity of potato spindle tuber viroid (PSTV), EMBO J. 4:2181 (1985).
T. O. Diener, Viroid processing: a model involving the central conserved region and hairpin I, Proc. Natl. Acad. Sci. USA 83:58 (1986).
J. W. Davies, P. Kaesberg, and T. O. Diener, Potato spindle tuber viroid. XII. An investigation of viroid RNA as messenger for protein synthesis, Virology 61:281 (1974).
M. Zuker, On finding all suboptimal foldings of an RNA molecule, Science 244:48 (1989).
P. Palukaitis, Potato spindle tuber viroid: investigation of the long distance intra-plant transport route, Virology 158:239 (1987).
R. C. Gardner, K. Chonoles, and R. A. Owens, Potato spindle tuber viroid infections mediated by the Ti plasmid of Acrrobacterium tumefaciens, Plant Mol. Biol. 6:221 (1986).
L. F. Salazar, R. W. Hammond, T. O. Diener, and R. A. Owens, Analysis of viroid replication following Acrrobacterium-mediated inoculation of non-host species with potato spindle tuber viroid cDNA, J. Gen. Virol. 69:879 (1988).
J. Yamaya, M. Yoshioka, T. Sano, E. Shikata, and Y. Okada, Expression of hop stunt viroid from its cDNA in transgenic tobacco plants: identification of tobacco as a host plant, Molecular Plant Microbe Interactions 2:169 (1989).
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Hammond, R.W., Owens, R.A. (1991). Analysis of Viroid Pathogenicity by Genome Modification. In: Herrmann, R.G., Larkins, B.A. (eds) Plant Molecular Biology 2. NATO ASI Series, vol 212. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3304-7_9
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DOI: https://doi.org/10.1007/978-1-4615-3304-7_9
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