Somatosensory Input to the Periaqueductal Gray: A Spinal Relay to a Descending Control Center

  • Robert P. Yezierski
Chapter
Part of the NATO ASI Series book series (NSSA, volume 213)

Abstract

The spinomesencephalic tract (SMT) with its varied origins (Mantyh, 1982; Menétrey et al., 1982; Swett et al., 1985; Wiberg and Blomqvist, 1984; Wiberg et al., 1987; Yezierski and Mendez, 1991; Zhang et al., 1990), spinal trajectories (Hylden et al., 1986b; Kerr, 1975; McMahon and Wall, 1985; Yezierski and Schwartz, 1986; Zemlan et al., 1978), and sites of termination (Anderson and Berry, 1959; McMahon and Wall 1985; Mehler, 1969; Morin, 1953; Björkeland and Boivie, 1984; Blomqvist and Craig, this volume; Yezierski, 1988) is often described as having a role in nociception (Bowsher, 1976; Mehler, 1969; Willis, 1985; Willis and Coggeshall, 1978; Yezierski, 1988). Consistent with this hypothesis are the responses of SMT cells to noxious mechanical and thermal stimuli (Hylden et al., 1986a; 1989; Menétrey et al., 1980; Yezierski and Schwartz, 1986; Yezierski et al., 1985). Furthermore, recent studies have shown SMT cells in the upper cervical and lumbosacral spinal cord respond to inputs from cutaneous and /or deep structures, including joints, muscles, and viscera (Yezierski and Broton, 1991; Yezierski and Schwartz, 1986; Yezierski et al., 1987; Yezierski, 1990). These observations as well as the varied functions associated with SMT projection targets supports a role of the SMT in sensory, motor and visceral functions.

Keywords

Depression Respiration Morphine Serotonin Peri 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Robert P. Yezierski
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Miami, School of MedicineMiamiUSA

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