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Thrombin pp 117–158Cite as

Synthetic Substrates and Inhibitors of Thrombin

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Abstract

Thrombin has a central regulatory role in hemostasis and is formed by both the intrinsic and extrinsic pathways of blood coagulation (Fenton, 1986, 1981). The major function of this serine protease is the cleavage of fibrinogen to form fibrin clots, but thrombin also activates factors V, VIII, XIII and protein C which are important in the control of hemostasis and thrombosis. In addition, thrombin can stimulate platelet secretion and aggregation in blood, and mediate other nonhemostatic cellular events. Our understanding of the various biological roles of thrombin has been facilitated by the development of convenient chromogenic and fluorogenic assays for the measurement of thrombin activity; and synthetic, low-molecular-weight inhibitors which are important probes for the study of thrombin’s mechanism, specificity, and function in the coagulation system.

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  1. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA, 30332

    James C. Powers & Chih-Min Kam

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    Lawrence J. Berliner

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Powers, J.C., Kam, CM. (1992). Synthetic Substrates and Inhibitors of Thrombin. In: Berliner, L.J. (eds) Thrombin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3296-5_4

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