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Strategies in β-lactam Design

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Emerging Targets in Antibacterial and Antifungal Chemotherapy

Abstract

It has been 50 years since Florey, Chain and their associates first described the treatment of staphylococcal and streptococcal infections with penicillin (49). This epoch-making discovery ushered in a new era of fruitful research culminating in the identification of the bacterial cell wall as the target of this β-lactam (222). Penicillin was found to act by inhibiting the cross-linking enzymes involved in the biosynthesis of peptidoglycan (PG), the major cell-wall polymer (298, 323). For many scientists, the design of β-lactams targeted specifically to these essential enzymes is the ultimate research goal in this area.

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  1. Francis C. Neuhaus
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  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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Neuhaus, F.C., Georgopapadakou, N. (1992). Strategies in β-lactam Design. In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_9

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