Protein secretion in bacteria: a chemotherapeutic target?

  • Rajeev Misra
  • Thomas J. Silhavy


The Escherichia coli cell is composed of four distinct compartments: the cytoplasm, an inner membrane, an outer membrane, and the periplasm, an aqueous compartment sandwiched between the two membranes. All proteins are synthesized in the cytoplasm and a subset of these are exported to noncytoplasmic locations. This process of protein export from the cytoplasm is an essential cellular function performed by a set of proteins discovered primarily through genetic studies. All proteins destined for the outer membrane or periplasmic space are first synthesized as precursors bearing an amino-terminal signal sequence of about 20 amino acids. Cleavage of the signal sequence by signal peptidase at the outer face of the inner membrane precedes proper localization of these exported protein.


Signal Sequence Protein Translocation Hybrid Protein Signal Peptidase Protein Export 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Rajeev Misra
  • Thomas J. Silhavy

There are no affiliations available

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