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Virulence-Associated Mannoproteins of Candida Albicans

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Emerging Targets in Antibacterial and Antifungal Chemotherapy

Abstract

The cell surface of Candida albicans has been the subject of considerable study over the past 10 years (69). What was originally thought to be a relatively static arrangement of three polysaccharides (glucan, chitin, and mannan), lipid, and some protein is now seen as an exceedingly complex mix of numerous components. There is good evidence, for example, that classes of mannoproteins exist which differ in regard to the degree of glycosylation, molecular weight, and function (enzymatic, structural, immunosuppression, ligand/receptors). Furthermore, mannoprotein can be growth-form specific, i.e. , found exclusively on germ tubes (15, 77), variable in expression, found in high numbers on exponential but not on stationary-phase yeast cells (or vice versa) (8–10), or spatially rearranged so as to appear as a cell-surface component in hyphae (or germ tubes) but buried within the wall in yeast-phase cells (57).

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Authors
  1. Richard A. Calderone
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  2. Makiko Fukayama
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  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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Calderone, R.A., Fukayama, M. (1992). Virulence-Associated Mannoproteins of Candida Albicans. In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_20

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