Rationally Designed Inhibitors of Sterol Biosynthesis

  • A. C. Oehlschlager
  • Eva Czyzewska


Sterols play vital hormonal, regulatory, and architectural roles in all living organisms. As knowledge of their biosynthetic pathways has grown, so has the possibility for manipulation. One of the most exciting and promising strategies to develop over the past 15 years has been the interference of specific sterol biosynthetic enzymes by mechanism-based inhibitors. Because sterol biosynthesis and its regulation vary among animals, plants, and fungi, this approach offers significant prospects for the rational design of chemotherapeutic agents aimed at the control of disease states ranging from arteriosclerosis to fungal infections.


Sterol Biosynthesis Amine Oxide Squalene Epoxidase Oxidosqualene Cyclase Sterol Biosynthesis Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • A. C. Oehlschlager
  • Eva Czyzewska

There are no affiliations available

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