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Rationally Designed Inhibitors of Sterol Biosynthesis

  • Chapter
Emerging Targets in Antibacterial and Antifungal Chemotherapy

Abstract

Sterols play vital hormonal, regulatory, and architectural roles in all living organisms. As knowledge of their biosynthetic pathways has grown, so has the possibility for manipulation. One of the most exciting and promising strategies to develop over the past 15 years has been the interference of specific sterol biosynthetic enzymes by mechanism-based inhibitors. Because sterol biosynthesis and its regulation vary among animals, plants, and fungi, this approach offers significant prospects for the rational design of chemotherapeutic agents aimed at the control of disease states ranging from arteriosclerosis to fungal infections.

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Authors
  1. A. C. Oehlschlager
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  2. Eva Czyzewska
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Editors and Affiliations

  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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Dedicated to the late Professor A. M. Unrau, a colleague and friend.

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© 1992 Springer Science+Business Media Dordrecht

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Oehlschlager, A.C., Czyzewska, E. (1992). Rationally Designed Inhibitors of Sterol Biosynthesis. In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_17

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  • DOI: https://doi.org/10.1007/978-1-4615-3274-3_17

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