Lipid A, a constituent of the outer membrane of gram-negative bacteria, is a structurally unique molecule that does not exist in animal cells. The lipid A of most gram-negative bacteria is structurally similar, with analogous biosynthetic steps. These facts, combined with the fact that lipid A is required for the survival of most, if not all gram-negative bacteria, make lipid A biosynthesis an excellent target for antibiotics.


Outer Membrane Neisseria Gonorrhoeae Enteric Bacterium Acyl Donor Nonpermissive Temperature 
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© Springer Science+Business Media Dordrecht 1992

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  • Jack Coleman

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