Network Model of the Respiratory Rhythm

  • Eliza B. Graves
  • William C. Rose
  • Diethelm W. Richter
  • James S. Schwaber

Abstract

We propose a model for the generation of the respiratory rhythm. The model is composed of four distinct neuron types recorded in vivo in the cat, defined by their phase relationship to the respiratory cycle as seen in the phrenic neurogram. It is proposed that the respiratory rhythm emerges from the connectivity and membrane dynamics of these neurons. Computational models are created of the four cell types using Hodgkin-Huxley form kinetics to describe active membrane properties that are then tuned to reproduce the recorded patterns of neuronal behavior. The neuronsare reciprocally connected with inhibitory synapses. Simulation results accurately reproduce the three-phased respiratory cycle, and demonstrate the way in which this activity may arise from intrinsic membrane, as well as network, properties.

Keywords

Dura 

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References

  1. [1]
    Richter, D.W., Champagnat, J., Mifflin, S. In Neurobiology of the Control of Breathing. Raven Press, 1986.Google Scholar
  2. [2]
    Conner, J.A., Walter, D., McKown, R. Biophys. J. 18: 81–102, 1977.CrossRefGoogle Scholar
  3. [3]
    Yamada, W.M., Koch, C. Adams, P.R. In Methods in Neuronal Modeling. MIT Press, 1989.Google Scholar
  4. [4]
    Coulter, D.A., Huguenard, J.R., Prince, D.A. J. Physiol. 414:587–604, 1989.Google Scholar
  5. [5]
    Cohen, M.I. J. Neurophysiol. 31:142–165,1969.Google Scholar
  6. [6]
    Smith, J.C., Greer, J., Liu, G., Feldman, J.L. J. Neurophysiol. 64:1149–1169, 1990.Google Scholar
  7. [7]
    Schwaber, J.S., Paton, J.F.R.P., Graves, E.B. Brain Res., in press.Google Scholar
  8. [8]
    Meves, H., Vogel, W. J. Physiol. 235: 225–264, 1973.Google Scholar
  9. [9]
    Partridge, L.D., Swandulla, D. Trends Neurosci. 11:69–72,1988.CrossRefGoogle Scholar
  10. [10]
    Lytton, W.W., Sejnowski, T.J. Personal communication.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Eliza B. Graves
    • 1
  • William C. Rose
    • 1
  • Diethelm W. Richter
    • 2
  • James S. Schwaber
    • 1
  1. 1.Neural Computation ProgramDuPont CompanyWilmingtonUSA
  2. 2.Physiology InstituteGeorg-August-Universät GöttingenGöttingenGermany

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