Platelet-derived growth factor release after angioplasty
The purpose of this chapter is to examine the role of platelet-derived growth factor (PDGF) in the vascular smooth muscle (VSMC) hyperplastic response that occurs in the intima of arteries after balloon angioplasty. This proliferative response results in the reappearance of stenoses in approximately 40% of the patients undergoing coronary balloon angioplasty. To place into perspective the role of PDGF in restenosis, the evidence implicating VSMC proliferation as the cause of restenosis and the approaches that have been used but have failed to resolve the problem are presented. Thereafter, recent cell and molecular biology studies which provide a foundation for the understanding of sources and possible roles of PDGF in restenosis are presented. Finally, PDGF release after angioplasty is described.
KeywordsBalloon Angioplasty PDGF Receptor Dilate Artery VSMC Proliferation Carotid Endarterectomy Specimen
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