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Genome organization and expression of the rat ACBP gene family

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Book cover Cellular Fatty Acid-Binding Proteins II

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 10))

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Abstract

Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

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Authors and Affiliations

  1. Institute of Biochemistry, University of Odense, Campusvej 55, DK-5230, Odense M, Denmark

    Susanne Mandrup, Per Hove Andreasen & Jens Knudsen

  2. Department of Molecular Biology, University of Odense, Campusvej 55, DK-5230, Odense M, Denmark

    Karsten Kristiansen

Authors
  1. Susanne Mandrup
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  2. Per Hove Andreasen
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  3. Jens Knudsen
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  4. Karsten Kristiansen
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Editors and Affiliations

  1. Department of Physiology, University of Limburg, Maastricht, The Netherlands

    Jan F. C. Glatz  & Ger J. van der Vusse  & 

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© 1993 Springer Science+Business Media Dordrecht

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Mandrup, S., Andreasen, P.H., Knudsen, J., Kristiansen, K. (1993). Genome organization and expression of the rat ACBP gene family. In: Glatz, J.F.C., van der Vusse, G.J. (eds) Cellular Fatty Acid-Binding Proteins II. Developments in Molecular and Cellular Biochemistry, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3096-1_8

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  • DOI: https://doi.org/10.1007/978-1-4615-3096-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6353-8

  • Online ISBN: 978-1-4615-3096-1

  • eBook Packages: Springer Book Archive

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