Fatty acid-binding protein and its relation to fatty acid oxidation

  • J. H. Veerkamp
  • H. T. B. van Moerkerk
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 10)


A relation between fatty acid oxidation capacity and cytosolic FABP content was found in heart and various muscles of the rat. Other tissues do not show such a relation, since they are involved in more or other pathways of fatty acid metabolism. At postnatal development FABP content and fatty acid oxidation capacity rise concomitantly in heart and quadriceps muscle in contrast to in liver and kidney. A dietary fat content of 40 en. % increased only the FABP content of liver and adipose tissue. Peroxisomal proliferators increased fatty acid oxidation in both liver and kidney, but only the FABP content of liver, and had no effect on heart and skeletal muscle. The FABP content of muscle did not show adaptation to various conditions. Only it increased in fast-twitch muscles upon chronic electrostimulation and endurance training.

Key words

fatty acid-binding protein fatty acid oxidation peroxisomal fatty acid oxidation diet postnatal development liver muscle 


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Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • J. H. Veerkamp
    • 1
  • H. T. B. van Moerkerk
    • 1
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands

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