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Options for Prevention of T Cell Alloactivation by Blood Transfusions

  • F. H. J. Claas
  • H. S. de Koster
  • E. L. Lagaaij
  • J. J. van Rood
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 28)

Abstract

Blood transfusions may have opposite immunological effects. They can either lead to immunization of the recipient or induce immunological tolerance. The latter effect might be very helpful for clinical transplantation, whereas immunization is generally considered to be a negative effect for both patients in need for further blood transfusions and for patients waiting for an organ transplantation. The most easy parameter for immunization is the presence of circulating alloantibodies. In HLA-alloimmunization, it is known that most of these alloantibodies are of the IgG type, which is a clear indication that also T cell activation has taken place during the immunization process. A pivotal role in allorecognition is played by CD4+ T cells, which recognize the foreign HLA class II molecules of the transfused cells. Once these CD4+ T cells are properly triggered by alloantigen presenting cells in the first phase of the immune response, they will, either directly or indirectly via cytokines and other factors, initiate and facilitate the actual effector processes of the immune response leading to IgG antibody formation and maturation of cytotoxic T lymphocytes. Therefore one can expect that prevention of activation of these CD4+ T cells may be an effective way to prevent alloimmunization. Induction of tolerance, is another possible strategy to prevent alloimmunization. For the induction of tolerance, we hypothesize that not prevention of activation but activation of certain (allopeptide specific) CD4+ T cells might be essential.

Keywords

Blood Transfusion Natural Killer Activity Kidney Graft Survival Natural Killer Cell Recognition Donor Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • F. H. J. Claas
  • H. S. de Koster
  • E. L. Lagaaij
  • J. J. van Rood

There are no affiliations available

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