Graft-Versus-Host Disease

  • J. Jansen
  • Q. Chang
  • L. P. Akard
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 28)

Abstract

The development of nuclear arms at the end of World War II was a major stimulus for research into radiation damage to the hematopoietic system and into the treatment of such damage through bone marrow transplantation [1]. A large body of research with mice, dogs, and monkeys established a “bone marrow syndrome” with death through the complications of pancytopenia after a total body dose of 5–7 Gy (500–700 rad). Such animals could be salvaged by the infusion of syngeneic bone marrow [2] or allogeneic bone marrow [3,4]. These studies were trailblazers for bone marrow transplantation as therapeutic modality in man.

Keywords

Toxicity Lymphoma Tyrosine Leukemia Corticosteroid 

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References

  1. 1.
    Santos GW. History of bone marrow transplantation. Clin Haematol 1983;12:611–41.PubMedCrossRefGoogle Scholar
  2. 2.
    Lorenz E, Uphoff DE, Reid TR, Shelton E. Modification of acute irradiation injury in mice and guinea pigs by bone marrow infections. J Nat Cancer Inst 1951; 12:197–201.PubMedGoogle Scholar
  3. 3.
    Lorenz E, Congdon CC. Modification of lethal irradiation injury in mice by injection of homologous and heterologous bone marrow. J Nat Cancer Inst 1954;14:955–61.PubMedGoogle Scholar
  4. 4.
    Van Bekkum DW, de Vries MJ. Radiation chimaeras. Logos Press Limited, New York, 1967.Google Scholar
  5. 5.
    Barnes DWH, Loutit JF. Treatment of murine leukaemia with x-rays and homologous bone marrow. II. Brit J Haematol 1957;3:241–52.CrossRefGoogle Scholar
  6. 6.
    Billingham RE, Brent L. A simple method for inducing tolerance of skin homografts in mice. Transplantation Bulletin 1957;4:67–71.PubMedGoogle Scholar
  7. 7.
    Billingham RE. The biology of graft-versus-host reactions. Harvey Lectures 1966-67;62:21–78.PubMedGoogle Scholar
  8. 8.
    Thomas ED, Storb R, Clift RA, et al. Bone-marrow transplantations. N Engl J Med 1975;292:832–43, 895-902.PubMedCrossRefGoogle Scholar
  9. 9.
    Sale G. Shulman HM (eds). The pathology of bone marrow transplantation. Masson Publishing USA, Inc., Seattle, 1984.Google Scholar
  10. 10.
    Brubaker DB. Human posttransfusion graft-versus-host disease. Vox Sang 1983; 45:401–20.PubMedCrossRefGoogle Scholar
  11. 11.
    Burdick JF, Vogelsang GB, Smith WJ, et al. Severe graft-versus-host disease in a liver-transplant recipient. Medical Intelligence 1988;318:689–91.Google Scholar
  12. 12.
    Deeg HJ, Storb R, Shulman H. Engraftment of DLA-nonidentical unrelated canine marrow graft after high-dose fractionated total body irradiation. Transplantation 1982;33:443–6.PubMedCrossRefGoogle Scholar
  13. 13.
    Vogelsang GB, Wagner JE. Graft-versus-host disease. Hemat/Oncol Clin Nrth Amer 1990;4:625–39.Google Scholar
  14. 14.
    Gale RP, Bortin MM, van Bekkum DW, et al. Risk factors for acute graft-versus-host disease. Brit J Haematol 1987;67:397–406.CrossRefGoogle Scholar
  15. 15.
    Neudorf S, Filipovich A, Ramsay N, Kersey K. Prevention and treatment of acute graft-versus-host disease. Sem Hematol 1984;21:91–100.Google Scholar
  16. 16.
    Beatty PG, Clift RA, Mickelson EM, et al. Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 1985;313:765–71.PubMedCrossRefGoogle Scholar
  17. 17.
    Ash RC, Casper JT, Chitambar CR, et al. Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med 1990;322:485–94.PubMedCrossRefGoogle Scholar
  18. 18.
    Starzl TE, Demetris AJ, van Thiel D. Liver transplantation. N Engl J Med 1989;321:1014–22,1092-9.PubMedCrossRefGoogle Scholar
  19. 19.
    Von Fliedner V, Higby DI, Kim U. Graft-versus-host reaction following blood product transfusion. Am J Med 1982;72:951–61.CrossRefGoogle Scholar
  20. 20.
    Anderson KC, Weinstein HJ. Transfusion-associated graft-versus-host disease. N Engl J Med 1990;323:315–21.PubMedCrossRefGoogle Scholar
  21. 21.
    Park BH, Good RA, Gate J, Burke B. Fatal graft-versus-host reaction following transfusion of allogeneic blood and plasma in infants with combined immunodeficiency disease. Transplant Proc 1974;6:385–7.PubMedGoogle Scholar
  22. 22.
    Parkman R, Mosier D, Umansky I, Cochran W, Carpenter CB, Rosen FS. Graft-versus-host disease after intrauterine and exchange transfusions for hemolytic disease of the newborn. N Eng J Med 1974;290:359–63.CrossRefGoogle Scholar
  23. 23.
    Dinsmore RE, Straus DJ, Pollack MS, et al. Fatal graft-versus-host disease following blood transfusion in Hodgkin’s disease documented by HLA typing. Blood 1980;55: 831–4.PubMedGoogle Scholar
  24. 24.
    Lowenthal RM, Grossman L, Goldman JM, et al. Granulocyte transfusions in treatment of infections in patients with acute leukemia and aplastic anaemia. Lancet 1975;i:353–8.CrossRefGoogle Scholar
  25. 25.
    Thaler M, Shamiss A, Orgad S, et al. The role of blood from HLA-homozygous donors in fatal transfusion-associated graft-versus-host disease after open-heart surgery. N Engl J Med 1989;321:25–8.PubMedCrossRefGoogle Scholar
  26. 26.
    Otsuka S, Kunieda K, Hirose M, et al. Fatal erythroderma (suspected graft-versus-host disease) after cholecystectomy: Retrospective analysis. Transfusion 1989;29: 544–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Holland PV. Prevention of transfusion-associated graft-versus-host disease. Arch Pathol Lab Med 1989;113:285–91.PubMedGoogle Scholar
  28. 28.
    Reisner Y, Kapoor N, Kirkpatrick D, et al. Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells from fractionated with soybean agglutinin and sheep red blood cells. Lancet 1981;ii:327-31.Google Scholar
  29. 29.
    De Witte T, Hoogenhout J, de Pauw B, et al. Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft-versus-host disease in matched allogeneic bone marrow transplantation. Blood 1986;67:1302–8.PubMedGoogle Scholar
  30. 30.
    Ferrara J, Deeg HJ. Graft-versus-host disease. N Engl J Med 1991;324:667–74.PubMedCrossRefGoogle Scholar
  31. 31.
    Korngold R, Sprent J. Lethal graft-versus-host disease across minor histocompatibility barriers in mice. In: Nathan DG (ed). Clinics in haematology 1983;681–93.Google Scholar
  32. 32.
    Unanue ER, Allen PM. The basis for the immunoregulatory role of macrophages and other accessory cells. Science 1987;236:551–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Samelson LE, Patel MD, Weissmann AM, Harford JB, Klausner RD. Antigen activation of murine T-cells induces tyrosine phosphorylation of a polypeptide associated with the T-cells antigen receptor. Cell 1986;46:1083–90.PubMedCrossRefGoogle Scholar
  34. 34.
    Ghayur T, Seemeyer TA, Kongshavn PAL, Gartner JG, Lapp WS. Graft-versus-host reactions in the beige mouse: An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease. Transplantation 1987;44: 261–7.PubMedCrossRefGoogle Scholar
  35. 35.
    Symington FW, Storb R. Mechanisms of tissue damage in human acute graft-versus-host disease. J Immunol Immunopharmacol 1989;9:214–9.Google Scholar
  36. 36.
    Piguet PF. Tumor necrosis factor and graft-versus-host disease. In: Burakoff SJ, Deeg HJ, Verrara J, Atkinson K (eds). Graft-vs-host disease: Immunology, pathophysiology and treatment. Marcel Dekker, New York 1990:225–76.Google Scholar
  37. 37.
    Ferrara JL, Guillen FJ, van Dijken PJ, Marion A, Murphy GF, Burakoff SJ. Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease. Transplantation 1989;47:50–4.PubMedCrossRefGoogle Scholar
  38. 38.
    Rappeport J, Mihm M, Reinherz E, Lopansri S, Parkman R. Acute graft-versus-host disease in recipients of bone-marrow transplantation from identical twin donors. Lancet 1979;ii:7 17-20.Google Scholar
  39. 39.
    Hess AD, Horwitz L, Beschorner WE, Santos GW. Development of graft-versus-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development ofcytotoxic Tlymphocytes with apparent polyclonal anti-la specificity, including autoreactivity. J Exp Med 1985; 161:718–30.PubMedCrossRefGoogle Scholar
  40. 40.
    Maraninchi D, Blaise, Rio B, et al. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias. Lancet 1987;i: 175–8.CrossRefGoogle Scholar
  41. 41.
    Mitsuyasu RT, Champlin RE, Gale RP, et al. Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. Ann Intern Med 1986;105:20–6.PubMedGoogle Scholar
  42. 42.
    Waldmann H, Hale G, Cividalli G, et al. Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet 1984;i:483–5.CrossRefGoogle Scholar
  43. 43.
    Reisner Y, Kapoor N, Kirkpatrick D, et al. Transplantation of severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood 1983;61:341–8.PubMedGoogle Scholar
  44. 44.
    Schattenberg A, de Witte T, Preijers F, et al. Allogeneic bone marrow transplantation for leukemia with marrow grafts depleted of lymphocytes by counterflow centrifugation. Blood 1990;75:1356–63.PubMedGoogle Scholar
  45. 45.
    Filipovich AH, Vallera D, McGlave P, et al. T-cells depletion with anti-CD5 immunotoxin in histocompatible bone marrow transplantation: The correlation between residual CD5 negative T-cells and subsequent graft-versus-host disease. Transplantation 1990;9:401–15.Google Scholar
  46. 46.
    Jansen J, Hanks S, English D, Karaffa R, Akard L. Immunomagnetic depletion of CD8+ lymphocytes from marrow grafts. In: Worthington-Write DA, Gee A, Gross S (eds). Advances in bone marrow purging and processing. Wiley-Liss, Inc, New York; 405–10.Google Scholar
  47. 47.
    Butturini A, Gale RP. T-cells depletion in bone marrow transplantation for leukemia: Current results and future directions. Bone Marrow Transpl 1988;3:185–92.Google Scholar
  48. 48.
    Sirchia G, Parravicini A, Rebulla P, Fattori L, Milani S. Evaluation of three procedures for the preparation of leukocyte-poor and leukocyte-free red blood cells for transfusion. Vox Sang 1980;38:197–204.PubMedCrossRefGoogle Scholar
  49. 49.
    Lane TA, Anderson KC, Goodnough LT, et al. Leukocyte reduction in blood component therapy. Ann Intern Med 1992;117:151–62.PubMedGoogle Scholar
  50. 50.
    Korngold R, Sprent J. T-cells subsets and graft-versus-host disease. An overview. Transplantation 1987;44:335–9.CrossRefGoogle Scholar
  51. 51.
    Gratama JW, Naipal A, Oljan, et al. T-lymphocyte repopulation and differentiation after bone marrow transplantation. II. Early shifts in the ratio between T4+ and T8+ T-lymphocytes correlated with the occurrence of acute graft-versus-host disease. Blood 1984;63:1416–23.PubMedGoogle Scholar
  52. 52.
    Gratama JW, de Groot-Swings G, Slats J, Zwaan FE, Jansen J. Correlation between the fraction size of the peripheral blood T8 T-lymphocyte subset of marrow donors and the development of acute graft-versus-host disease. Exp Hematol 1984;12:51–2.Google Scholar
  53. 53.
    Champlin R, Ho W, Gajewski J, et al. Selective depletion of CD8+ lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood 1990;76:418–23.PubMedGoogle Scholar
  54. 54.
    Champlin R, Jansen J, Ho W, et al. Retention of graft-versus-leukemia using selective depletion of CD8-positive Tlymphocytes for prevention of graft-versus-host disease following bone marrow transplantation for chronic myelogenous leukemia. Transplant Proc 1991;23:1695–6.PubMedGoogle Scholar
  55. 55.
    Sprent J, Anderson RE, Miller JF. Radiosensitivity of T and B lymphocytes. II. Effect of irradiation on response of T-cells to alloantigens. Eur J Immunol 1974;4: 204–10.PubMedCrossRefGoogle Scholar
  56. 56.
    Valerius NH, Johansen KS, Nielson OS, Platz P, Rosenkvist J, Sørenson H. Effect of in vitro x-irradiation on lymphocyte and granulocyte function. Scand J Haematol 1981;27:9–18.PubMedCrossRefGoogle Scholar
  57. 57.
    Rosen NR, Weidner JG, Boldt HD, Rosen DS. Prevention of transfusion associated graft-versus-host disease. Selection of adequate dose of gamma radiation. Transfusion 1993;33:125–7.PubMedCrossRefGoogle Scholar
  58. 58.
    Zwaan FE. Haemopoietic cells in human peripheral blood. (Thesis). J.H. Pasman,’ s-Gravenhage 1980.Google Scholar
  59. 59.
    Deeg HJ, Bazar L, Sigaroudinia M, Cottler-Fox M. Ultraviolet B light inactivates bone marrow Tlymphocytes but spares hematopoietic precursor cells. Blood 1989; 73:369–71.PubMedGoogle Scholar
  60. 60.
    Cohn ML, Cahill RA, Deeg HJ. Hematopoietic reconstitution and prevention of graft-versus-host disease with UVB-irradiated haploidentical murine spleen and marrow cells. Blood 1991;78:3317–22.PubMedGoogle Scholar
  61. 61.
    Deeg HJ, Graham TC, Gerhard-Miller L, Appelbaum FR, Schuening F, Storb R. Prevention of transfusion-induced graft-versus-host disease in dogs by ultraviolet irradiation. Blood 1989;74:2592–5.PubMedGoogle Scholar
  62. 62.
    Kahan BD, Cyclosporine. N Eng J Med 1989;321:1725–38.CrossRefGoogle Scholar
  63. 63.
    Atkinson K, Biggs JC, Hayes J, et al. Cyclosporin A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: Three distinct syndromes. Brit J Haematol 1983;54:59–67.CrossRefGoogle Scholar
  64. 64.
    Leitner C, Sinzinger H, Pohanka E, Schwarz M, Kretschmer G, Syré. Occurrence of hemolytic uremic syndrome under cyclosporine treatment: Accident or possible side effect mediated by a lack of prostacyclin-stimulating plasma factor. Transplant Proc 1983;15(suppl 1):571–3.Google Scholar
  65. 65.
    Markus PM, Cai X, Ming W, Demetris AJ, Fung JJ, Starzl TE. FK506 reverses acute graft-versus-host disease after allogeneic bone marrow transplant in rats. Surgery 1991;8:357–64.Google Scholar
  66. 66.
    Markus PT, Cai X, Ming W, Demetris AJ, Fung JJ, Starzl TE. Prevention of graft-versus-host disease following allogeneic bone marrow transplantation in rats using FK506. Transplantation 1991;52:590–4.PubMedCrossRefGoogle Scholar
  67. 67.
    Fung JJ, Slessiani M, Abu-Elmagd K, et al. Adverse effects associated with the use of FK506. Transplant Proc 1991;15:3105–8.Google Scholar
  68. 68.
    Storb R, Deeg HJ, Pepe M, et al. Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: Long-term follow-up of a controlled trial. Blood 1989; 73:1729–34.PubMedGoogle Scholar
  69. 69.
    Atkinson K, Matias C, Guifere A, et al. In vivo administration of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, interleukin-1 (IL-1), and IL-4 alone and in combination, after allogeneic murine hematopoietic stem cell transplantation. Blood 1991;77:1376–82.PubMedGoogle Scholar
  70. 70.
    McCarthy PL, Abhyankar S, Neben S, et al. Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease. Blood 1991;78:1915–8.PubMedGoogle Scholar
  71. 71.
    Hervé P, Wijdenes J, Bergerat JP, et al. Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10). Blood 1990;75:1017–23.PubMedGoogle Scholar
  72. 72.
    Fahr A, Langer R, Ziegoleit S. Influence of pentoxifylline administered in vivo on synthesis of prostacyclin in human varicos veins. Biomed Bioclin ACTA 1988; 14: 29–36.Google Scholar
  73. 73.
    Han J, Thompson P, Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med 1990;172:391–8.PubMedCrossRefGoogle Scholar
  74. 74.
    Bianco JA, Appelbaum FR, Nemunaitis J, et al. Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood 1991;78:1205–11.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • J. Jansen
  • Q. Chang
  • L. P. Akard

There are no affiliations available

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