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Graft-Versus-Host Disease

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Immunology and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 28))

Abstract

The development of nuclear arms at the end of World War II was a major stimulus for research into radiation damage to the hematopoietic system and into the treatment of such damage through bone marrow transplantation [1]. A large body of research with mice, dogs, and monkeys established a “bone marrow syndrome” with death through the complications of pancytopenia after a total body dose of 5–7 Gy (500–700 rad). Such animals could be salvaged by the infusion of syngeneic bone marrow [2] or allogeneic bone marrow [3,4]. These studies were trailblazers for bone marrow transplantation as therapeutic modality in man.

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  1. J. Jansen
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  2. Q. Chang
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  3. L. P. Akard
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. University of Groningen, The Netherlands

    T. H. The (Professor of Clinical Immunology) (Professor of Clinical Immunology)

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Jansen, J., Chang, Q., Akard, L.P. (1993). Graft-Versus-Host Disease. In: Sibinga, C.T.S., Das, P.C., The, T.H. (eds) Immunology and Blood Transfusion. Developments in Hematology and Immunology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3094-7_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3094-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6352-1

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