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Sarcolemmal Cation Transport Systems in Rat Hearts Acclimatized to High Altitude Hypoxia: Influence of 7-Oxo-Prostacyclin

  • A. Ziegelhöffer
  • J. Grünermel
  • A. Dzurba
  • J. Procházka
  • F. Kolár
  • N. Vrbjar
  • V. Pelouch
  • B. Ostádal
  • L. Szekeres
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 140)

Abstract

Acclimatization to intermittent high altitude (IHA) is characterized by the development of polycythemia, pulmonary hypertension and right ventricular hypertrophy. Furthermore, at the beginning of the adaptation process, necrotic lesions can be observed, localized predominantly in the right ventricle (1, 2). In this connection, it is interesting to note that such an affected myocardium exhibits a significantly increased resistance to acute anoxia “in vitro”, as well as to isoproterenol-induced myocardial lesions (3, 4). Recently, we have observed that in hearts acclimatized to IHA the sarcolemmal Na, K-ATPase, Mg-ATPase and low affinity Ca-ATPase exhibited decreased Vmax and Km values; the latter being considered as a sign of adaptation to hypoxia at the enzyme level (5).

Keywords

Ventricular Weight Left Ventricular Weight High Altitude Hypoxia Actual ATPase Activity Acute Anoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Widimsky J, Urbanová D, Ressl J, Ostádal B, Pelouch V, Procházka J. Cardiovasc Res 1973;7:789–808.CrossRefGoogle Scholar
  2. 2.
    Widimsky J, Ostádal B, Urbanová D, Ressl J, Procházka J, Pelouch V. Chest 1980;77:383–389.PubMedCrossRefGoogle Scholar
  3. 3.
    Poupa O, Krofta K, Procházka J, Turek Z. Fed Proc 1966;25:1243–1246.PubMedGoogle Scholar
  4. 4.
    McGrath J, Procházka J, Pelouch V, Ostádal B. J Appl Physiol 1973;34:289–293.PubMedGoogle Scholar
  5. 5.
    Ziegelhöffer A, Procházka J, Pelouch V, Ostádal B, Dzurba A, Vrbjar N. Physiol Bohemoslov 1987;36:403–415.PubMedGoogle Scholar
  6. 6.
    Takáts I, Szekeres L. Acta Physiol Hung 1985;66:390.Google Scholar
  7. 7.
    Udvary E, Végh A, Szekeres L. Pharmacol Res Commun 1988;20:171–172.CrossRefGoogle Scholar
  8. 8.
    Szekeres L, Szilvássy Z, Udvary E, Végh A. Pharmacol Res Commun 1988;20(Suppl I):77–78.CrossRefGoogle Scholar
  9. 9.
    Szekeres L, Németh M, Szilvássy Z, Tósaki A, Udvary E, Végh A. Biomed Biochim Acta 1988;47:6–7.Google Scholar
  10. 10.
    Szekeres L, Koltai M, Pataricza G, Takáts I, Udvary E. Biomed Biochim Acta 1987;43:135–142.Google Scholar
  11. 11.
    Dzurba A, Ziegelöffer, A Breier A, Vrbjar N. Cardioscience 1991;2:105–108.PubMedGoogle Scholar
  12. 12.
    Fulton RN, Hutchinison EC, Jones AN. Brit Heart J 1952;14:413–420.PubMedCrossRefGoogle Scholar
  13. 13.
    Chronic cor pulmonale. WHO report of an expert committee. World Health Organization Technical Report Series, No. 213, Geneva, 1961; pp. 92.Google Scholar
  14. 14.
    Dhalla NS, Lee SL, Anand MB, Chauhan MS. Biochem Pharmacol 1977;26:2050–2060.CrossRefGoogle Scholar
  15. 15.
    Fedelesová M, Dzurba A, Ziegelhöffer A. In: Recent Advances of Studies on Cardiac Structure and Metabolism, Vol. 9. The Sarcolemma (eds.) PE Roy, NS Dhalla. University Park Press, Baltimore, Maryland, 1976; pp. 303–309.Google Scholar
  16. 16.
    Ziegelhöffer A, Breier A, Dzurba A, Vrbjar N. Gen Physiol Biophys 1983;2:447–456.PubMedGoogle Scholar
  17. 17.
    Ziegelhöffer A, Dhalla NS. J Mol Cell Cardiol 1979;11(Suppl II):69.CrossRefGoogle Scholar
  18. 18.
    Szekeres L, Udvary E, Végh A. J Mol Cell Cardiol 1985;17(Suppl III):Abstract No. 129.Google Scholar
  19. 19.
    Szilvássy Z, Udvary E, Szekeres L, Végh A. J Mol cell Cardiol 22(Suppl III):PT 17.Google Scholar
  20. 20.
    Vrbjar N, Slezák J, Ziegelhöffer A, Tribulová N. Eur Heart J, 1991; in press.Google Scholar
  21. 21.
    Slezák J, Tribulová N. J Mol Cell Cardiol 1990;22(Suppl III):PF32, s.66.CrossRefGoogle Scholar
  22. 22.
    Stankovicová T, Zemková H, Ziegelhöffer A, Vyskocil F. Brit J Pharmacol 1991; in press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. Ziegelhöffer
    • 1
  • J. Grünermel
    • 2
  • A. Dzurba
    • 1
  • J. Procházka
    • 2
  • F. Kolár
    • 2
  • N. Vrbjar
    • 1
  • V. Pelouch
    • 2
  • B. Ostádal
    • 2
  • L. Szekeres
    • 3
  1. 1.Institute for Heart ResearchSlovak Academy of SciencesBratislavaCzechoslovakia
  2. 2.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCZECHOSLOVAKIA
  3. 3.Institute of PharmacologyAlbert Szent-Györgyi UniversitySzegedHUNGARY

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