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The changing role of staging laparotomy in the management of Hodgkin’s disease

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Book cover Malignant lymphomas, including Hodgkin’s disease: Diagnosis, management, and special problems

Part of the book series: Cancer Treatment and Research ((CTAR,volume 66))

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Abstract

Staging laparotomy with splenectomy for Hodgkin’s disease was introduced at Stanford University in the late 1960s as part of ongoing research protocols. It illuminated the patterns of spread of the disease, clarified why many patients with clinically localized disease relapsed after receiving limited radiation therapy, and led to the development of modern treatment protocols, with corresponding improvements in freedom from relapse (FFR) and survival rates for many patients. Recent advances in diagnostic imaging, large studies defining groups of patients at high and low risk for occult subdiaphragmatic disease, cooperative trials demonstrating excellent treatment results for clinically staged patients, and the development of new, effective, and possibly less toxic chemotherapy regimens have challenged oncologists to reexamine the role of staging lapparotomy [1]. Physicians continue to strive to improve cure rates while minimizing the risk of short-and long-term complications due to either staging procedures, initial treatment protocols, or potential second or third treatment regimens.

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Authors
  1. Mark H. Leibenhaut
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Editors and Affiliations

  1. Oregon Health Sciences University, USA

    Bruce W. Dana (Clinical Associate Professor of Medicine, Member) (Clinical Associate Professor of Medicine, Member)

  2. The Hematology Clinic Portland, Oregon, USA

    Bruce W. Dana (Clinical Associate Professor of Medicine, Member) (Clinical Associate Professor of Medicine, Member)

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Leibenhaut, M.H. (1993). The changing role of staging laparotomy in the management of Hodgkin’s disease. In: Dana, B.W. (eds) Malignant lymphomas, including Hodgkin’s disease: Diagnosis, management, and special problems. Cancer Treatment and Research, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3084-8_1

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  • DOI: https://doi.org/10.1007/978-1-4615-3084-8_1

  • Publisher Name: Springer, Boston, MA

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