Preoperative chemotherapy for soft tissue sarcomas of the extremities: The experience at the University of California, Los Angeles

  • C. Jay Engel
  • Frederick R. Eilber
  • Gerald Rosen
  • Michael T. Selch
  • Yao-Shi Fu
Part of the Cancer Treatment and Research book series (CTAR, volume 67)

Abstract

The traditional approach to extremity sarcomas was surgical excision. This was associated with a local failure rate of approximately 95% [1], as tumors were simply ‘shelled out’ of their pseudocapsule. More radical muscle group and compartment excisions were then performed that reduced the local failure to approximately 40% [2]. Even with amputation, local failure was approximately 35%. Without effective additional therapy to control microscopic residual disease, radical surgery alone resulted in both poor functional results and high recurrence rates.

Keywords

Catheter Oncol Sarcoma Doxorubicin Cyclophosphamide 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • C. Jay Engel
  • Frederick R. Eilber
  • Gerald Rosen
  • Michael T. Selch
  • Yao-Shi Fu

There are no affiliations available

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