Preoperative chemotherapy for soft tissue sarcomas of the extremities: The experience at the University of California, Los Angeles
The traditional approach to extremity sarcomas was surgical excision. This was associated with a local failure rate of approximately 95% , as tumors were simply ‘shelled out’ of their pseudocapsule. More radical muscle group and compartment excisions were then performed that reduced the local failure to approximately 40% . Even with amputation, local failure was approximately 35%. Without effective additional therapy to control microscopic residual disease, radical surgery alone resulted in both poor functional results and high recurrence rates.
KeywordsSoft Tissue Sarcoma Preoperative Chemotherapy Limb Salvage Soft Tissue Sarcoma Microscopic Residual Disease
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