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Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation

  • Chapter
Oncogene and Transgenics Correlates of Cancer Risk Assessments

Part of the book series: NATO ASI Series ((NSSA,volume 232))

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Abstract

One of the most intensively studied non-genotoxic carcinogens is the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). Since TPA appears to exert its biologic effects through protein kinase C (PKC), a key enzyme in signal transduction, we have studied this enzyme in considerable detail. To explore the role of PKC in carcinogenesis we developed various types of cell lines that overproduce the PKC βI isoform. To gain further insight into the relationship between PKC structure and its function in tumor promotion we expressed deletion mutants of PKC βI in a rat fibroblast cell line. These studies provide genetic evidence that PKC plays a critical role in growth control and the action of certain growth factors, tumor promoters and oncogenes. The findings are discussed within the context of multistage carcinogenesis, risk assessment, and cancer prevention.

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Authors and Affiliations

  1. Comprehensive Cancer Center and Institute of Cancer Research, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, N.Y., 10032, USA

    Kevin R. O’Driscoll, Scott M. Kahn, Christoph M. Borner, Wei Jiang & I. Bernard Weinstein

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  1. Kevin R. O’Driscoll
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  2. Scott M. Kahn
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  3. Christoph M. Borner
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  4. Wei Jiang
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  5. I. Bernard Weinstein
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  1. Consulting in Health and Environmental Protection, Simpsonville, Maryland, USA

    Constantine Zervos

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© 1992 Springer Science+Business Media New York

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O’Driscoll, K.R., Kahn, S.M., Borner, C.M., Jiang, W., Weinstein, I.B. (1992). Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation. In: Zervos, C. (eds) Oncogene and Transgenics Correlates of Cancer Risk Assessments. NATO ASI Series, vol 232. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3056-5_4

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  • DOI: https://doi.org/10.1007/978-1-4615-3056-5_4

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-3056-5

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