Characteristics of Foreign and Self Peptides Endogenously Bound to MHC Class I Molecules

  • Grada M. van Bleek
  • Stanley G. Nathenson
Part of the NATO ASI Series book series (NSSA, volume 233)


The immune response against intracellular pathogens is mediated by cytotoxic T lymphocytes (CTL) which recognize components of the invader in combination with self molecules of an infected cell. These self products are encoded in the class I region of the Major Histocompatibility Complex (MHC) and the process is termed MHC restriction (1). Originally it was thought that proteins of the infectious agent were present in close proximity to the surface MHC molecule where they could be simultaneously contacted by the T cell receptor (TCR). Therefore it was hypothesized that spike proteins of viruses which are present on cell surfaces after fusion with the cell membrane at cell entry, or before virus budding, would be likely candidates for such a dual recognition. However, from studies with influenza viruses with variations in the nonsurface exposed nucleoprotein (Np) it was learned that, unlike antibodies, the major population of influenza specific CTL recognize the Np rather than the surface exposed hemagglutinin (2). Studies in which the Np gene or parts thereof were transfected into L-cells further showed that the influenza CTL were specifically recognizing a linear peptide stretch in Np (3). Moreover the specific CTL response could be triggered when short synthetic peptides were mixed in vitro with antigen presenting cells carrying the appropriate MHC class I molecules (4).


Major Histocompatibility Complex Major Histocompatibility Complex Class Antigenic Peptide Vesicular Stomatitis Virus Anchor Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Zinkernagel, R.M. and Doherty, P.C. Adv. Immun. 27, 51–177 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    Townsend, A.R.M. and Skehel, J.J. J. Exp. Med. 160, 552–563.Google Scholar
  3. 3.
    Townsend, A.R.M., Gotch, F.M. and Davey, J. Cell 42, 457–467 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    Townsend, A.R.M. et al. Cell 44, 959–968 (1986).PubMedCrossRefGoogle Scholar
  5. 5.
    Bjorkman, P.J. et al. Nature 329, 506–512 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    Bjorkman, P.J. et al. Nature 329, 512–518 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    Garrett, T.P.J., Saper, M.A., Bjorkman, P.J., Strominger, J.L. and Wiley, D.C. Nature 342, 692–696 (1989).PubMedCrossRefGoogle Scholar
  8. 8.
    Berkower, I., Buckenmeyer, G.K. and Berzofsky, J.A. J. of Immunol. 136, 2498–2503 (1986).Google Scholar
  9. 9.
    Allen, P.M., Matsueda, G.R., Evans, R.J., Dunbar, J.B. Jr., Marshall, G.R. and Unanue, E.R. Nature 327, 713–715 (1987).PubMedCrossRefGoogle Scholar
  10. 10.
    Rothbard, J.B. and Taylor, W.R. EMBO J. 7, 93–100 (1988).PubMedGoogle Scholar
  11. 11.
    van Bleek, G.M. and Nathenson, S.G. Nature 348, 213–216 (1990).PubMedCrossRefGoogle Scholar
  12. 12.
    Puddington, L., Bevan, M.J., Rose, J.K., and Lefrancois, L. J. of Virol. 60, 708–717 (1986).Google Scholar
  13. 13.
    Shibata, K., Imarai, M., van Bleek, G.M., Joyce, S. and Nathenson, S.G. Proc. Nat. Acad. Sci. USA, in press.Google Scholar
  14. 14.
    van Bleek, G.M. and Nathenson, S.G. Proc. Natl. Acad. Sci. USA 88, 11032–11036 (1991).PubMedCrossRefGoogle Scholar
  15. 15.
    Falk, K., Rotzschke, O., Stevanovic, S., Jung, G. and Rammensee, H.-G. Nature 351, 290–296 (1991).PubMedCrossRefGoogle Scholar
  16. 16.
    Kast, W.M. et al. Cell 59, 603–614 (1989).PubMedCrossRefGoogle Scholar
  17. 17.
    Schumacher, T.N.M. et al. Cell 62, 563–567 (1990).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Grada M. van Bleek
    • 1
  • Stanley G. Nathenson
    • 1
  1. 1.Albert Einstein College of MedicineBronxUSA

Personalised recommendations